Biomedical subjects
S Sadaoka
Publications and source records attributed to S Sadaoka.
[Comparative study of the physical properties of microcatheters frequently used for abdominal IVR].
The purpose of this study was to determine the physical properties of commercially available microcatheters through basic experiments. The materials included eleven different types of widely used microcatheters, ten of which were 135 cm in length and the remaining one 113 cm. Five samples of each catheter were examined. For each catheter, we measured the flow rate, flexibility of the tip, rigidity of the proximal part, smoothness of the outer and inner surfaces, kink resistance of the tip, and pressure resistance of the whole catheter. In conclusion, an ideal microcatheter should satisfy the following criteria: 1) the internal lumen must be large enough to allow high flow volume, and the wall must be enforced by braiding to withstand higher injection pressure; 2) the tip of the catheter must be soft, but must increase in hardness as it approaches the proximal end; 3) it must have a hydrophilic coating on the surface for an appropriate length.
[Facial nerve neurinoma with extension to middle cranial fossa].
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Extended intraarterial cisplatin infusion for treatment of gynecologic cancer after alteration of intrapelvic blood flow and implantation of a vascular access device.
PURPOSE: Twenty-two patients with advanced gynecologic cancer underwent extended intraarterial cisplatin infusion after alteration of the intrapelvic blood flow and implantation of a vascular access device (VAD). METHODS: To maximize concentrations of cisplatin at the target lesion, the superior and inferior gluteal arteries were embolized with steel coils. The tip of the catheter was inserted into the internal iliac artery; the opposite end of the catheter was connected to the VAD. RESULTS: Intensive radioisotope accumulation was demonstrated in the anterior division of the pelvis, seen by scintigraphy performed with technetium 99m macroaggregated albumin via the VAD. Local perfusion in the tumor was well seen by ultrasonographic angiography with CO2 microbubbles via the VAD. Continuous consecutive infusion of cisplatin at a rate of 12.5 mg/day via the VAD minimized the toxicity. The overall response rate was 73%. Radical surgery was possible in 16 of the 22 patients after this intraarterial infusion. CONCLUSION: This method was useful for treating advanced gynecologic cancer without significant toxicity.