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Biomedical subjects

S Safaie-Shirazi

Publications and source records attributed to S Safaie-Shirazi.

At least 19 recordsLinked to original sources
PubMed1983

The effect of secretin on pancreatic blood flow in the awake and anesthetized dog.

The canine pancreatic blood flow was studied after iv secretin (resulting in a plasma level commensurate with the postcibal state), and also after larger iv doses and after duodenal acidification. We found that blood flow was unaffected by "physiological" doses of secretin, or by perfusion of duodenum at a pH as low as 2.0, but increased by bolus doses (0.5 CU/kg and above), and by acidification to pH 1.4. Anesthesia does not affect the blood flow response although the bicarbonate response appeared to be blunted under anesthesia. We conclude that increase in pancreatic blood flow is not a physiological effect of secretin.

Anesthesia↗
PubMed1976

Treatment of reflux esophagitis resulting in massive esophageal bleeding.

The complications that occur secondary to sliding hiatal hernia are reflux esophagitis with ulceration, stricture formation, and hemorrhage. We have treated seven patients for massive esophageal bleeding secondary to reflux esophagitis. All had endoscopic evidence of reflux esophagitis and a negative work-up for other sources of bleeding. All underwent Nissen fundoplication as the only mode of therapy for the bleeding esophagitis. No patient has bled again; healing of the esophagitis was evident six weeks after operation, as observed by gastrointestinal endoscopy. This operation prevents reflux, has minimal side-effects, and gives consistent results in the hands of the average trained gastrointestinal surgeon.

Adult↗
PubMed1976

Dilation of esophageal strictures. A new technique controlled by fiberoptic endoscopy.

Dilation of peptic esophageal strictures visually controlled by means of fiberoptic endoscopy was carried out in 16 patients. The dilation was performed by passing the woven silk bougies alongside the endoscope, so that the process could be observed in detail. The technique affords a better view of the procedure because of a wider visual angle and because the field of vision is not blocked by the bougie, as would be the case with the rigid endoscope. The size of the bougie employed is not limited by the size of the endoscope. All 16 patients, with and without subsequently undergoing Nissen fundoplication, were able to eat a normal diet after therapy.

Aged↗
PubMed1976

The effect of metiamide, an H2-receptor antagonist, in the prevention of experimental stress ulcers.

Because of evidence that Metiamide, an H2-receptor antagonist, strongly inhibits gastric acid secretion, the present study was designed to test the hypothesis that Metiamide will prevent bile salt-induced stress ulcers during hemorrhagic shock. Forty dogs were bled and maintained for 4 1/2 hr at a mean blood pressure of 40 to 50 mm Hg. In group A, 10 dogs received 300 mg of Metiamide orally 45 min before bleeding and 10 dogs received normal saline. The pylorus was occluded before bleeding and 100 ml of 15 mM bile salt were instilled into the stomach and aspirated at the end of 4 1/2 hr. At the time the animal was killed after 48 hr, no ulcers were seen in the stomachs of dogs treated with Metiamide. Sixty per cent of the dogs in the untreated group developed multiple gross ulcers. In group B the effect of Metiamide on the disappearance rate of H+ ion was measured by instillation of 50 mM HCl + 15 mM bile acid. No difference was noted in the rate of H+ ion disappearance between Metiamide-treated and control dogs. Also, in 5 normotensive dogs the rate of H+ ion disappearance was measured before and after treatment with Metiamide, and the loss of H+ was identical for both periods. Metiamide was effective in preventing stress ulcer in this experimental model. The protective effect of Metiamide is probably due to its inhibitory effect of H+ ion secretion.

Administration, Oral↗
PubMed1975

Esophageal stricture secondary to reflux esophagitis.

Since 1966 we have used esophageal dilation plus Nissen fundoplication as our sole method of treating esophageal strictures caused by reflux esophagitis. Twenty-six patients were treated for esophageal strictures. Dysphagia, vomiting, and weight loss were the main complaints. All had roentgenographic evidence of esophageal stricture confirmed by endoscopy. All patients had preoperative or intraoperative dilation of the stenotic segment with a Hurst dilator, followed by Nissen fundoplication as the antireflux operation of choice. This more conservative approach, which corrects both the reflux and stricture problem, has not been associated with mortality nor has there been any morbidity associated with the dilation procedure. All patients thus treated have remained asymptomatic on normal alimentation for the follow-up period, which ranges from six months to seven years.

Body Weight↗
PubMed1975

Hepatic artery ligation and cytotoxic infusion in treatment of liver neoplasms.

Since 1970, 38 patients with multiple primary or secondary liver neoplasms have been treated by hepatic artery ligation and distal cytotoxic infusion with fluorouracil. There have been two postoperative deaths. Although liver enzymes (alkaline phosphatase, serum glutamic oxaloacetic transaminase, and lactic dehydrogenase) rise markedly during the first three days, they usually return to preoperative levels within eight days. The median survival time of all patients, including the two postoperative deaths, was 13.3 months. The longest patient survival was 44 months. In the eight patients still living, the median survival time is 17 months, ranging from 11 to 27 months. Substantial palliation can be achieved by hepatic artery ligation and infusion with minimal morbidity and mortality.

Alkaline Phosphatase↗