PubMed Health⌕ Search

Biomedical subjects

S Sagar

Publications and source records attributed to S Sagar.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Effect of antihypertensive therapy on plasma lipids and lipoproteins in mild hypertension.

Antihypertensive drugs have been incriminated for altering the lipid profile of hypertensives, obscuring the beneficial effect of blood pressure reduction on coronary artery disease. The effects of Propranolol, Nifedipine and Hydrochlorothiazide on plasma lipid fractions in recently diagnosed mild hypertensives, randomly allocated to PROP, NIF, HCT groups were studied at 0, 12 and 24 weeks of treatment. Target DBP of less than or equal to 90 mmHg was achieved in all the groups of patients. At 24 weeks, skewed distribution of lipid components was observed in PROP and NIF groups without significant alteration in various lipid fractions. In HCT group, TG increased and HDL-C and HDL-C/CH decreased significantly. Long-term significance of these changes, which make the lipid profile more atherogenic, needs to be considered while treating hypertensives.

Adult↗
PubMedDate not supplied

Clonidine suppression test--an evaluation of its diagnostic significance in hypertensive patients.

The Clonidine Suppression Test (CST) was performed in 8 patients with Labile hypertension (Group I), 8 patients with mild and moderate Essential hypertension (Group IIa), 8 patients with severe Essential hypertension (Group IIb) and 6 patients with pheochromocytoma (Group III). The mean plasma catecholamine (CA) levels as estimated by a Spectrofluorimetric method were significantly reduced 3-4 hours after administration of clonidine (5 micrograms/kg) by mouth in Group I, IIa & IIb patients. Plasma norepinephrine levels fell from 1.82 +/- SEM 0.35 ng/ml to 1.03 +/- 0.11 ng/ml (p less than 0.05) in Group I, 1.64 +/- 0.36 ng/ml to 0.88 +/- 0.12 ng/ml (p less than 0.025) in Group IIa, 1.23 +/- 0.16 ng/ml to 0.86 +/- 0.12 ng/ml (p less than 0.005) in Group IIb patients. Plasma epinephrine levels fell from 0.35 +/- 0.06 ng/ml to 0.16 +/- 0.03 ng/ml (p less than 0.05) in Group I, 0.34 +/- 0.04 ng/ml to 0.22 +/- 0.03 ng/ml (p less than 0.01) in Group IIa, 0.33 +/- 0.06 ng/ml to 0.18 +/- 0.03 ng/ml (p less than 0.025) in Group IIb patients. The blood pressure and heart rate showed a similar response. By contrast, in patients with pheochromocytoma, the mean plasma CA levels did not show any significant fall, and even rose during the CST, but, when repeated post-operatively, showed normal suppression. No serious side effects were noticed. We conclude that the CST is a safe and reliable test for the diagnosis of pheochromocytoma.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Gland Neoplasms↗