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Biomedical subjects

S Sakamoto

Publications and source records attributed to S Sakamoto.

At least 829 records · Page 46Linked to original sources
PubMed1980

Effect of hypothalamic deafferentation on the distribution of luteinizing hormone-releasing hormone (LHRH) in the rat brain.

Anterior (AHD) and complete hypothalamic deafferentation (CHD) were performed in female rats to ascertain the origin of LHRH detected in the external layer of ME. Deafferented brains were serially sectioned in a cryostat in the frontal plane. LHRH activity in each section was determined by RIA. While AHD, using a knife with a small radius caused no change in the distribution of LHRH in the brain, AHD, using a knife with a large radius resulted in a significant decrease in LHRH content in the ARC-ME. CHD caused a more marked decrease in the ARC-ME LHRH than AHD. The decrease was more marked in the anterior and posterior portions of the ARC-ME than in the middle one. These effects of CHD on the distribution of LHRH in the ME were ascertained by immunohistochemical studies. In contrast, LHRH content in the POA showed no significant change after AHD and CHD. However, a few LHRH containing fibers were observed in the area lying just proximal to the cut by immunohistochemistry. These results strongly suggest that a part of the LHRH detected in the external layer of ME is derived from that synthesized outside the MBH, possibly in the POA and another part is derived from that synthesized inside the MBH, possibly in the ARC.

Afferent Pathways↗
PubMed1980

Identification of drug resistance (R) plasmids from catheter urine.

We isolated bacterial strains from catheter urine of patients with underlying diseases and investigated their resistance to various drugs. It was found that Serratia marcescens strains were most frequently isolated, from which R plasmids were identified at a high frequency (70%). According to the resistance patterns of R plasmids, prevalence of multiply resistant S. marcescens strains was concluded by selection of the organism according to drugs used and by infection with the organism, and the spread of R plasmids encoding multiple resistance.

Bacteriuria↗
PubMed1980

Urinary fibrinolysis in toxemia of pregnancy.

Serial determinations of urinary plasmin level by radiocaseinolytic assay were performed in 40 healthy women and 29 patients with various types of toxemia throughout pregnancy, labor and the puerperium. The results indicate that: 1. The urinary plasmin level in normal pregnancy increased significantly from the third trimester to the early puerperium. 2. In mild pre-eclampsia, a significant rise in urinary plasmin level from 26 weeks of gestation to the 4th day post-partum. 3. In severe pre-eclampsia, a progressive decrease in late pregnancy was found. After delivery, in the early puerperium, the urinary plasmin level of the patients with a rapid clinical was significantly higher than that of the patients with the sequelae of toxemia. Our study showed that serial assays of urinary plasmin activity can provide a reliable and sensitive index of severity, progression and natural history of toxemia of pregnancy.

Abruptio Placentae↗
PubMed1980

[Treadmill exercise testing in patients with idiopathic cardiomyopathy (author's transl)].

Multistage treadmill stress testing was performed in 24 patients with idiopathic cardiomyopathy using Bruce protocol. 5 patients were considered to have hypertrophic obstructive cardiomyopathy (HOCM), 12 hypertrophic nonobstructive cardiomyopathy (HCM) and 7 congestive cardiomyopathy (CCM). Heart rate, systemic blood pressure, electrocardiographic changes and exercise tolerance were observed. The effect of propranolol on exercise tolerance was investigated in HOCM and HCM. 1) Exercise duration was less in patients with HCM and HOCM than in normal subjects (50 subjects) and greater than in 50 anginal patients. In CCM, exercise duration was the least. 2) Electrocardiographic changes observed in HCM and HOCM were increase of T waves and lessening of ST depression. In CCM, appearance of ventricular arrhythmia was noted in 4 of 7 patients. 3) Maximam exercise tolerance was reached at Bruce state III-IV in HOCM, stage III in HCM and stage II in CCM. 4) Propranolol administration resulted in improvement of exercise tolerance in 3 of 7 patients with HOCM and HCM.

Adult↗