Biomedical subjects
Publications and source records attributed to S Sandqvist.
Balloon catheters with latex balloons were inflated in plastic tubes of different diameters. The volume at rupture of the balloons was measured. The pressure inside the balloon and that caused by the balloon against the tube walls were recorded. Measures to avoid high pressure on the vessel wall, and balloon rupture, are discussed.
In a double-blind trial of tranexamic acid in massive upper gastrointestinal haemorrhage, 76 patients were treated with the active drug and 73 patients with placebo. The doses were 1 g intravenously six times daily for a maximum of 3 days, followed by 1.5 g orally four times daily for a maximum of 4 days. The treatment group and the placebo group were comparable with respect to mean age, diagnoses and laboratory tests but differed slightly with respect to sex and alcohol consumption. The transfusion requirement in the treatment group was less than in the placebo group during the first days after admission, the difference being significant on the second day after admission. Ten patients in the treatment group and 18 patients in the placebo group were operated on. Eleven patients in the treatment group and 12 patients in the placebo group died. In the tranexamic-acid-treated group fewer operations were performed and significantly less blood was needed. It therefore seems highly likely that tranexamic acid has a beneficial effect, although small.
The renal effect of angiotensin has been recorded in patients by determination of variations in the length of the kidney and by selective injection of contrast medium into the renal artery with special angiographic techniques. The experiments demonstrate the rapid onset of the angiotensin effect on the renal vessels. The effect on kidney length was considerably prolonged compared with the vascular effect.
A device for injections of vasoactive agents at angiography connected with an injector for contrast medium and a film changer is described. It enables the examination to be performed according to predetermined data with a high degree of reproducibility. It lends itself particularly to experimental investigations of pharmacologic effects within various vascular areas.
Explore the source record for details and available documents.
Explore the source record for details and available documents.