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Biomedical subjects

S Sathe

Publications and source records attributed to S Sathe.

28 records · Page 2Linked to original sources
PubMed1992

Coronary-pulmonary artery fistula arising distal to obstructive coronary lesions.

We report 2 cases of coronary-pulmonary artery fistulae (CPF) arising distal to obstructive coronary artery disease. The fistula in the first patient was in the form of a tortuous dilatation of the distal portion of the right coronary artery and opened into the right pulmonary artery. In the second case, the fistula, a plexus of vessels, arose from the left anterior descending artery and entered the left pulmonary artery. Both the fistulae were successfully ligated at the time of concurrent coronary artery bypass graft surgery.

Aged↗
PubMed1992

Single coronary artery: a report of 2 cases.

An isolated single coronary artery is a rare congenital anomaly. We report 2 patients each of whom had a single coronary artery with an obstructive atherosclerotic lesion in one of its branches. In the first patient angioplasty was successfully performed using a perfusion catheter whilst in the second, the procedure was considered inappropriate as the patient had chronic total occlusion.

Angioplasty, Balloon, Coronary↗
PubMed1991

Closely linked lesions in a region of the X chromosome affect central and peripheral steps in gustatory processing in Drosophila.

We have analyzed a set of closely linked mutations on the X chromosome of Drosophila that lead to defects in gustatory behavior. The mutations map to a small region of the X chromosome between 10E1-4. Two distinct complementation groups, gustB and gustD, map to the ends of this region. These groups show complex complementation patterns with the mutations gustC and GT-1, which also map to this region. We describe the behavioral and electrophysiological properties of the mutants. These mutations affect peripheral receptor properties as well as more central processing steps in the gustatory pathway.

Animals↗
PubMed1989

HIV-2-associated AIDS in the United States. The first case.

A 41-year-old woman from the Cape Verde Islands, Africa, who had been residing in the United States for 11 months was found to have human immunodeficiency virus type 2 (HIV-2)-associated acquired immunodeficiency syndrome (AIDS). Antibody to HIV-2 was found by enzyme immunoassay and was verified by radioimmunoprecipitation. The patient was being treated for pulmonary tuberculosis at the time of her admission to our institution. Further laboratory and clinical evaluation at our facility revealed depressed CD4 lymphocytes, oral candidiasis, and cryptococcal meningitis with indeterminate results on serologic testing for HIV type 1 (HIV-1). The biopsy specimen of a lesion in the right occipital lobe of the brain documented Toxoplasma gondii, indicating a clinical diagnosis of AIDS. To our knowledge, our study presents the first known patient with HIV-2-associated AIDS in the United States. Our patient provides further evidence that HIV-2 causes severe immunodeficiency and opportunistic infection. The condition should be suspected in the face of normal or repeatedly equivocal HIV-1 antibody test results in the presence of clinically documented AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Uridine uptake inhibition as a cytotoxicity test: correlations with the Draize test.

The effects of 25 xenobiotic chemicals on the uptake of [3H]-uridine by Balb/c 3T3 cells were assessed. The test compounds, which included alcohols, ethers, esters, ketones, amides, acids and a detergent, inhibited uridine uptake at concentrations lower than those required to kill the cells; thus uridine uptake inhibition is a more sensitive indicator of toxic action than is cell lethality. The concentration of agent required to induce a 50% inhibition in uridine uptake rates after 4 h of treatment was determined for each agent, and this value (UI-50) was used to rank the potency of the test agents. This ranking correlated well with published data on the chemicals' capacity to induce ocular irritation in rabbits (the Draize test). Combinations of agents with differing functional groups produced additive uridine uptake inhibitory effects, suggesting the utility of this approach for the analysis of mixtures. Cells treated with levels of agents that reduced uridine uptake by 60-80% were able to recover most of their uridine uptake capacity after refeeding, indicating that the test shares with in vivo tests the ability to demonstrate recovery from toxic insult. This uridine uptake assay system provides a quantitative and rapid method for assessing toxicity that correlates well with Draize test results.

Animals↗
PubMedDate not supplied

Unruptured aneurysm of sinus of Valsalva: report of 2 cases.

2 cases of unruptured aneurysm of the sinus of Valsalva are presented. Both the patients had involvement of the right sinus of Valsalva. One of the patients had associated systemic lupus erythematosus (SLE). Such an association has not been described in the literature. Clinical, echocardiographic and the angiographic features have been discussed and literature reviewed.

Adult↗