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S Sauder

Publications and source records attributed to S Sauder.

3 recordsLinked to original sources
PubMed2005

Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients.

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor, that is involved in lipid and glucose metabolism, which both seem to influence the risk of Alzheimer's disease (AD). 24S-Hydroxycholesterol is the major cholesterol elimination product of the brain and plasma and CSF 24S-hydroxycholesterol levels are altered in patients with neurodegenerative diseases. We investigated the effect of the common Pro12Ala variant of the PPARgamma gene on plasma cholesterol levels and 24S-hydroxycholesterol/ cholesterol ratios in 124 AD patients and 77 healthy controls. Furthermore, the influence of PPARgamma polymorphism on the risk of AD in 247 AD patients and 324 healthy controls was investigated. We found that PPARgamma Pro12Ala polymorphism influenced plasma 24S-hydroxycholesterol/ cholesterol ratios in AD patients in that carriers of the Ala allele presented with higher ratios than homozygote carriers of the Pro-allele. PPARgamma polymorphism did not influence the risk of AD. These results might point to an influence of PPARgamma Pro12Ala polymorphism on the elimination of 24S-hydroxycholesterol.

Aged↗
PubMed1985

Evidence for decreased secretion of gonadotropin-releasing hormone in pubertal boys during short-term testosterone treatment.

Information about the site(s) of action as well as the age-dependent effects of sex steroids on gonadotropin-releasing hormone and gonadotropin secretion during human puberty is limited. To begin to address these questions, we evaluated the effects of a depot preparation of testosterone (testosterone enanthate) on gonadotropin secretion and pituitary responses to synthetic GnRH in 10, early to mid-pubertal boys who had either isolated GH deficiency (n-2) or delayed adolescent maturation (n-8). Chronological and bone age ranges were 13 1/12-16 1/12 and 11-14 yr, respectively. Frequent blood withdrawal studies (every 20 min for 20 consecutive h) were performed in the Clinical Research Center over two consecutive weekends. Following each study, gonadotropin responses to GnRH (0.25 microgram/kg iv bolus) were determined. During the initial study, all boys showed a sleep-entrained increase in luteinizing hormone (LH) and testosterone (T) secretion; mean nocturnal concentrations of LH and T were 2.3-fold greater than daytime values. At the end of the first study, testosterone enanthate was given im (0, 25, 50, or 75 mg/m2). Six days later, mean plasma T concentrations were in the pubertal to mid adult male range and were constant throughout the day: 25 mg/m2, 3.7 +/- 0.4 (SE) ng/ml; 50 mg/m2, 4.6 +/- 0.2 ng/ml; and 75 mg/m2, 6.7 +/- 0.4 ng/ml. T treatment had no effect on pituitary responses to GnRH: mean LH increment was 8.5 mIU/ml before and 10.0 mIU/ml after T treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗