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S Sawazaki

Publications and source records attributed to S Sawazaki.

25 records · Page 2Linked to original sources
PubMed1989

Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake.

Epidemiological studies were performed in a Japanese fishing village when catches of fish were highest and in a Japanese farming village with usual fish consumption. Intake of eicosapentaenoic, docosahexaenoic and also arachidonic acid were significantly higher in the fishing village during the 3 days of the study than in the farming village. The correlation between eicosapentaenoic acid intake on the day when urine was collected and excretion of delta 17-2,3-dinor-6-keto-prostaglandin F1 alpha, the main urinary metabolite of prostaglandin I3, was highly significant, whereas there was no correlation between arachidonic or linoleic acid intake and excretion of 2,3-dinor-6-keto-prostaglandin F1 alpha, the main urinary metabolite of prostaglandin I2. We suggest that the arachidonic acid pool for prostaglandin I2 production is not quickly influenced by dietary linoleic or arachidonic acid because of a large pool size of arachidonic acid and a slow conversion of linoleic acid to arachidonic acid, while prostaglandin I3 formation is directly related to the intake of eicosapentaenoic acid.

6-Ketoprostaglandin F1 alpha↗
PubMed1989

Comparison of the increment in plasma eicosapentaenoate concentrations by fish oil intake between young and middle-aged volunteers.

The effect of age on eicosapentaenoic acid (20:5 n-3; EPA) incorporation into plasma lipids was investigated in young volunteers (8 males, 19 +/- 1 yr) and middle-aged volunteers (6 males, 53 +/- 7 yr). They were asked to take 5.4 g fish oil per day for one week. The increment in EPA in the cholesteryl ester fraction after the supplementation was significantly greater in the middle-aged group (delta = 1.69%) than in the young group (delta = 0.44%) (p less than 0.05). The food intake analyzed for 3 consecutive days just before the supplementation revealed that the young group took more linoleate (17 vs. 10 g) than the middle-aged group. There was a significant inverse correlation between the increment in EPA in the cholesteryl ester fraction after the supplementation and daily linoleate intake among all the volunteers combined (r = -0.63, p less than 0.02). The higher increment in EPA in cholesteryl ester in the middle-aged group might be due to less intake of linoleate and not due to the difference in age itself.

Administration, Oral↗
PubMed1988

Comparison of pulse wave velocity of the aorta between inhabitants of fishing and farming villages in Japan.

Pulse wave velocity (PWV) of the aorta was measured in 55 inhabitants of fishing villages and in 49 inhabitants of farming villages, where people normally eat less fish than in the fishing villages. The PWV was significantly slower (indicating less sclerosis) in the fishing villages than in the farming villages (P less than 0.005). This is consistent with a lower incidence of ischemic heart disease in a coastal area, which includes the fishing villages, than in a mountainous area, including the farming villages. It is reported that a long-term fish-diet slows down sclerotic changes of arteries.

Adult↗
PubMed1986

Comparison of the urinary metabolites of prostacyclin and thromboxane of the 2- and 3-series in a Japanese fishing and a Japanese farming village.

We measured PGI2-, PGI3-, and TXA2/3-M (the main urinary metabolites of prostacyclin and thromboxane of the two and three series) in 24-hour urine in a fishing village (21 participants) and a farming village (19 participants) in Japan, expecting to find more PGI3-M in the fishing village than in the farming village. The food consumption for three consecutive days prior to a blood collection was recorded and analyzed for eicosapentaenoic acid (EPA) content. Urine was collected for 24 hours prior to the blood sampling. When our studies were performed (April, 1985), catches of fish were the lowest on record around the fishing village, and the consumption of EPA in the fishing village was less than half of that in the farming village. EPA levels in red cell membrane phospholipids were higher in the fishing village than in the farming village. PGI2-, PGI3-, and TXA2/3-M levels were higher in the farming village than in the fishing village. There was a significant correlation between PGI2- and PGI3-M (r=0.80, n=40) and between PGI3-M and the EPA consumption during the day of urine collection (r=0.52, n=40). We conclude that PGI3 production is probably dependent less on the levels of EPA in tissues estimated by the EPA levels in red cell membranes than on the EPA consumption at the moment.

Adult↗
PubMed1986

[A study on the effect of (2"R)-4'-O-tetrahydropyranyladriamycin, a new antitumor antibiotic, on reproduction. III. Its effects on perinatal and postnatal rats].

This paper describes effects of (2"R)-4'-O-tetrahydropyranyladriamycin hydrochloride (THP) on perinatal and postnatal rats. The drug was administered intravenously to female rats at 0.01, 0.03 or 0.1 mg/kg daily from day 17 of pregnancy to 21 days after delivery. Results were described below. At any dose levels tested, THP did not affect the body weight gain, food and water consumption by pregnant rats, and length of gestation period or delivery rate. However, at the highest dose level, THP decreased spleen weight. THP, at any dose levels, did not have toxic effect on development, physiological functions, behavior, mating, fertility or pregnancy of the first generation offspring (F1). At the highest dose of 0.1 mg/kg, however, THP produced delayed ossification of sacrococcygeal vertebra in the second generation fetuses (F2). The results suggest that the maximum "no effect" dose of THP to pregnant rats and offsprings is 0.03 mg/kg/day intravenously.

Animals↗
PubMed1984

[Toxicological studies on a new cephamycin, MT-141. X. Its perinatal and postnatal test in rats].

A perinatal and postnatal study of MT-141 was performed in SD rats. The dams were administered intramuscularly (i.m.) with MT-141 at the dose levels of 400, 800 and 1,600 mg/kg/day from the day 17 of gestation until the day 21 post delivery. The results are summarized as follows. No significant adverse effects of MT-141 were observed on the body weight gain, food consumption and water intake in dams of all groups treated with the drug during the perinatal and postnatal period. MT-141 did not change parameters of reproductive study in birth, development, physiological function and behavior of F1 rat. This compound had no effect on the fertility in F1 rats and also did not caused significant defects in the external appearance, viscera and skeleton of fetuses from dams (F1). It is concluded from these results that the maximal "no effective" dose of MT-141 is above 1,600 mg/kg/day i.m. for dams and the offsprings.

Animals↗