Perinatal and neurobehavioral predictors of one-year outcome in infants less than or equal to 1500 grams.
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Biomedical subjects
Publications and source records attributed to S Schechner.
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Because of the poor survival rates among sick infants weighing less than 750 gm and because of the poor quality of life of surviving infants, a less aggressive approach seems appropriate. Obstetricians, pediatricians, and neonatologists must explain the risks and benefits of intensive care frankly and honestly to families and accept their own limitations.
Thirty infants weighing less than 1,500 g at birth and requiring assisted ventilation were studied by computed tomography (CT) as soon as possible after birth and at intervals thereafter. Hemorrhage were frequently detected within the first 48 hr of birth. Two infants had normal scans initially but developed intraventricular hemorrhage later. One infant had subependymal hemorrhage that later ruptured into the ventricles. Six deaths were due directly to intracranial hemorrhages. Hydrocephalus developed in seven and atrophy in two survivors. There was poor correlation between CT scan and clinical evidence of intracranial hemorrhage.
Two methods of providing assisted ventilation were compared in infants severely ill with hyaline membrane disease (HMD). 10 infants were assigned to each group. One group received ventilation with a volume-cycled respirator, and the other was ventilated using a pressure-limited ventilator and reversed I:E ratio. Both groups were well matched for severity of illness in terms of pH and blood gases. pH and PO2 were quickly corrected by both ventilators. However, the pressure-cycled ventilator group had higher survival and lower complication rates. PAO2 after one hour was substantially improved at the same FIO2 in the pressure-limited group and after 8 hours the FIO2 required to maintain a PaO2 of 50--70 mmHg (6.6--9.3 kPa) was significantly decreased compared with the volume-cycled group. No effects on blood pressure were detected in either group. The study shows that the pressure-limited method is significantly better.