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Biomedical subjects

S Schickendantz

Publications and source records attributed to S Schickendantz.

17 recordsLinked to original sources
PubMed1994

Efficacy of pulmonary artery banding in the prevention of pulmonary vascular obstructive disease.

In 57 nonconsecutive pediatric patients (mean age: 2.6 months) with shunt-related pulmonary hypertension, the efficacy of pulmonary artery banding (PAB) was analysed retrospectively with special reference to the development of pulmonary vascular obstructive disease (PVOD). The patients were grouped in accordance to morphology, hemodynamics and incidence of PVOD. Efficacy of PAB was assessed by pulmonary to systemic pressure, flow and resistance ratios obtained by heart catheterization performed pre- and postoperatively. PAB was very effective in 49 out of 57 patients (= 85.9%), in 8 cases a progression or possible progression of PVOD must be suggested. Only Down syndrome can be considered as a predisposing factor for the development of PVOD. Based on our results we conclude that PAB is a high effective procedure in the prevention of PVOD; however, despite the surgical effectiveness of PAB, PVOD can occur. Strict post-PAB examination of pulmonary flow and resistance parameters is recommended and the definite surgical repair should be performed as early as possible.

Female↗
PubMed1989

[Magnetic resonance tomography in pediatric cardiology].

Magnetic resonance imaging (MR) is a relatively new non-invasive imaging method that has not been used as a routine procedure in pediatric cardiology. To evaluate MR in pediatric cardiology we performed 110 examinations in 91 children during the period from December, 1984, to November, 1987. The children were divided into the following groups: 1) Diseases of the great vessels (54 examinations in 39 children); 2) Cardiac diseases (42 examinations in 39 children); 3) Diseases of the pericardium (four examinations in three children); 4) Ten children without cardiovascular diseases (imaging of the heart in conjunction with examination of other organs). The ages of the children ranged from five weeks to 19 years in the following distribution: 13% infants, 20% children 2-5 years, 30% children 6-14 years, 37% adolescents from 15 to 19 years. On the basis of our experiences we conclude that MR can be used as an additional diagnostic tool in pediatric cardiology, especially for imaging of areas that are not well visualized by echocardiography, i.e., the great vessels and their branches and in addition, the right ventricle, in older children.

Adolescent↗
PubMed1988

[Noninvasive determination of oxygen saturation using pulse oximetry in pediatric cardiology].

Pulse oximetry is a relatively new noninvasive method to measure arterial oxygen saturation (SO2). We evaluated the reliability of a pulse oximeter (N-100, Nellcor/Drger, Lübeck) in single and continuous measurements of SO2. During cardiac catheterisation we compared pulse oximeter (puls.SO2) measurements to those in simultaneously taken arterial samples (art.SO2), and obtained 203 pair measurements in 85 patients, mostly newborns and infants; in 20 of them before and during the breathing of oxygen through a mask. We also have 67 pair measurements of capillary blood samples (kap.SO2) and puls.SO2. Continuous measurements with the pulse oximeter were carried out in 17 patients for up to 116 h. Our main results are: 1. In the puls.SO2 range of 66% to 100% the measurements with the pulse oximeter were accurate (r = 0.97, Syx = 2.1). Below 66% the puls.SO2 values were on average much higher than the art.SO2 values, with an increased variance. Intraindividual oxygenation changes before and during the breathing of oxygen were accurately measured. 2. Pulse oximetry is much more informative than kap.SO2 measurements, because its information about the SO2 before blood sampling (= resting value) and following SO2 changes during the painful procedure (= stress values). 3. Continuous measurements with the pulse oximeter are very simple and very reliable and are not associated with skin injury. Because the pulse oximeters responses rapid to oxygenation changes and does not need calibration it is very valuable in the assessment of therapeutic procedures in patients with cyanotic heart disease. We conclude that the pulse oximeter is a very important new diagnostic tool in pediatric cardiology.

Blood Gas Monitoring, Transcutaneous↗
PubMed1986

[Diagnosis and treatment of cardiac rhabdomyomas].

A diagnosis of primary cardiac tumors was achieved by two-dimensional echocardiography in 3 patients. Two of them were female neonates, born of the 29th and 40th gestational week who had shown intrauterine arrhythmias. Subsequently, we were able to diagnose tuberous sclerosis in both. The third child, a 121/2 year old boy, with already diagnosed tuberous sclerosis, presented an electrocardiographical preexcitation syndrome. Because of the multiplicity of the tumors and the association with tuberous sclerosis we presumed that the tumors were rhabdomyomas. As it is known that rhabdomyomas show no, or only a minimal postnatal growth, we decided neither to perform a heart catheterization nor to treat them surgically unless the children show hemodynamical deterioration, although the tumors were huge in both neonates. The subsequent 14 months showed a clear regression in the size of the tumors. One of the neonates was successfully treated with amiodarone because of ventricular tachycardia. The second neonate didn't require any treatment. We conclude that: Surgical management is only necessary in patients presenting with cardiac insufficiency and/or arrhythmias that are resistant to conventional medical treatment. Primary cardiac tumors should be looked for in patients presenting with arrhythmias, even when occurring already during intrauterine life. Diagnostic measures in order to diagnose tuberous sclerosis in patients with cardiac tumors are necessary and vice versa.

Adolescent↗
PubMed1986

[Diastolic micropotentials in high-resolution surface ECG in QT syndrome].

Patients suffering from long QT syndrome are threatened by torsade de pointes tachycardias and sudden arrhythmic cardiac death. An inhomogenic sympathetic innervation of the heart with dominance of the left cervicothoracic sympathetic nerves has been considered to be a major cause of life threatening cardiac arrhythmias. This study presents the electrocardiographic and electrophysiologic results of 7 patients with long QT syndrome. In agreement with data published earlier our results of Holter monitoring, exercise testing and programmed electrical right ventricular stimulation were of no diagnostic or prognostic significance in predicting syncopal attacks or sudden arrhythmic cardiac death. Thus, the high resolution ECG methods played an important role in this study. During noninvasive recordings of signal averaged ECGs and high resolution surface ECGs with beat to beat registration, diastolic microvolt potentials could be detected in 6/7 patients within the ST segment and in 5/7 patients after the T wave. Our results evidently show that the signal averaged ECG and the high resolution surface ECG could be of diagnostic significance in patients with long QT syndrome.

Adolescent↗
PubMed1984

[Cortical hyperostoses after long-term prostaglandin E2 therapy].

Cortical hyperostoses are found to be side effects after therapy in early infancy with prostaglandin E1 and E2. Correlation seems to exist between dosage and duration of therapy. Radiologically the lesions cannot be differentiated from Caffey's disease. Pathogenetic relationship of the two diseases is discussed; 62 cases of newborn children with ductal related vitium cordis, who were treated for a short time or for longer with prostaglandin E2 are demonstrated.

Dinoprostone↗
PubMed1976

Nutritive and non-nutritive blood flow in canine skeletal muscle after partial microembolization.

Partial microembolization of the previously dilated gastrocnemius muscle of the dog was performed by intra-arterial injection of latex microspheres (max. diameter 50 mum). No particles larger than 10 mum were recovered from the venous blood. Blood to tissue clearance of 4-amino-antipyrine was found to decrease after microembolization, and capillary transport coefficients were disproportionately lowered in comparison with the observed decrease of total blood flow. Venous oxygen saturation increased despite decreasing total blood flow in the working muscle after microembolization. The data indicate a shift of blood flow from nutritive to functionally non-nutritive channels.

Aminopyrine↗
PubMed1976

Method for simultaneous determination of red cell and plasma flow velocity in vitro and in vivo.

A method is described which can be used to simultaneously determine the flow velocity of plasma and of red blood cells in small glass tubes in vitro or in living microvessels of the microcirculation. The principle of dual slit photometry is applied to the measurement of plasma flow by determining the passage time of a dye bolus across two photodetectors separated by a variable distance. Measurements performed both in vitro and in vivo indicate a significant difference (up to 85%) between cellular and plasmatic flow velocity.

Animals↗
PubMedDate not supplied

[Silent persistent ductus arteriosus].

We report on 14 observations undertaken by ourselves of silent persistent ductus arteriosus (SPDA). During a three year period with the routine use of color doppler flow evaluation we found cases of SPDA in 14 children. A very little ductus arteriosus is already known to us through earlier heart catheter examinations which were undertaken because of other isolated heart defects (16 cases in 345 isolated heart defects over 10 years). We also consider the fact that SPDA is not an infrequent result after the occlusion of a patent ductus arteriosus with the Rashkind-Occluder-System and after operative ligatures of patent ductus arteriosus. Finally, we compare our results concerning the frequency of SPDA with current literature and discuss consequential therapies.

Blood Flow Velocity↗