PubMed Health⌕ Search

Biomedical subjects

S Schindler

Publications and source records attributed to S Schindler.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Adenosarcoma and other uterine sarcomas].

Sarcomas are tumors of conjunctive origin, rarely relating to the gynaecological sphere; among these, the adenosarcoma only represent one particular aspect. From one clinical case and from literature, the authors attempt to sum up the situation on the different clinical, para-clinical and therapeutic aspects of those bad-know neoplasia.

Adenosarcoma↗
PubMed1996

[Therapy of post-stroke depression with fluoxetine. A pilot project].

Depression is a common but often unrecognized complication after cerebrovascular stroke. Tricyclic antidepressants (TCA) have been found to be effective in poststroke depression, but side effects such as orthostatic hypotension, arrhythmia limit their wider use. In this pilot study the effects of treatment with the specific serotonin reuptake inhibitor (SSRI) fluoxetine (20 mg) in 10 severely depressed patients (HAM-D score between 27 and 35) after cerebrovascular stroke were investigated. Four patients dropped out of the study prematurely because of worsening of their condition (n = 4) and one patient discontinued the study because of transfer to a nursing home. After 3 weeks of fluoxetine treatment there was a significant amelioration in all the measured scores (HAM-D, Beck, CGI and Barthel: P < 0.05). At the end of the study one patient with recurrent cerebrovascular lesions still had an HAM-D score of 25, but the other four patients had HAM-D scores between 6 and 11. The physical rehabilitation scores measured with the Barthel Index showed negative correlations with the HAM-D, Beck and CGI scores for most items; this has to be interpreted with caution considering the number of patients involved in this investigation. The authors suggest that future double blind trials are warranted to test the efficacy of fluoxetin therapy for poststroke depression. Methodological problems in connection with pharmacological trials in these severely ill patients are discussed.

Aged↗
PubMed1996

Risk of suicide in depression and its implication for psychopharmacological treatment.

Suicide is one of the leading causes of death among adults in the general population. There is a well-established relationship between suicide and mood disorders and it has been estimated that 50-80% of completed suicides are associated with mood disorders. About 15% of depressed patients commit suicide, with tablet poisoning (mostly antidepressants) often chosen as the suicide method. Naturally, this presents the doctor with a dilemma since certain antidepressants are suitable both for the treatment of depression and for a suicide attempt. Two questions seem to be of particular practical relevance in this respect, which will be reviewed and discussed in more detail in this paper: (1) can antidepressants induce a suicidal tendency? and (2) can the degree of toxicity of antidepressants be estimated in cases of overdosage? There is no evidence that newer antidepressants, like the selective serotonin reuptake inhibitors (SSRIs), induce a suicidal tendency as has been suggested by a spectacularly written case report. In fact, it seems likely that antidepressants with a predominantly serotonergic mechanism of action may be of particular benefit in patients with suicidal problems, which is in line with neurobiological theories about suicidal behaviour. This and the decreased toxicity of SSRIs makes them an attractive choice for treatment of depressed patients who are at risk for suicide.

Antidepressive Agents↗
PubMed1995

[EEG changes in schizophrenic diseases--a critical review].

To identify specific changes in the electroencephalogram of schizophrenic patients has been an important target of clinical neurophysiology ever since the introduction of the EEG. Results of EEG-amplitude- and frequency-analysis in schizophrenics--although sometimes contradictory--are presented. Special emphasis is laid upon possible clinical applicabilities, for instance the prediction of the clinical course by means of neurophysiological changes after administration of a neuroleptic test dose. Finally, the usefulness of examining electrophysiological changes in such a heterogeneous group, as schizophrenics are, is discussed critically.

Antipsychotic Agents↗
PubMed1994

MTT-assay and neutral red release (NRR)-assay: relative role in the prediction of the irritancy potential of surfactants.

A comparative study on the in vitro and in vivo irritancy of anionic, amphoteric and non-ionic surfactants was performed. In vitro ED50 values of the surfactants were determined by two cytotoxicity assays, the dimethylthiazoldiphenyltetrazoliumbromide (MTT) assay and the neutral red release (NRR) assay on serum-free cultured human foreskin keratinocytes. In vivo human irritancy data were obtained by a 24 hour occlusive patch test in volunteers and the irritant skin response quantified by visual scoring, evaporimetry and colorimetry. A close relationship between the evaluation methods of the patch test was observed (r = 0.92 to r = 0.96), confirming that the 'bioengineering' methods, such as evaporimetry and colorimetry are suitable for measuring skin irritation. For six surfactants evaluated we found a good correlation (r = 0.91) between the ED50 values of the MTT assay and the in vivo irritancy data. The NRR assay yielded less satisfactory correlation coefficients with regard to MTT assay (r = 0.42) and in vivo irritancy data (r = 0.46). This can be mainly attributed to a misinterpretation of the amphoteric and non-ionic surfactants by the NRR assay. While the NRR assay may better evaluate the anionic surfactants, the MTT assay seems to be more suitable when testing a broader range of chemically diverse surfactants. Limitations of cell culture systems are noted, although the potential usefulness of cultured human skin cells for skin irritancy testing has been clearly demonstrated.

Adult↗
PubMed1991

[Differential diagnosis of transplant function disorders in therapy with monoclonal antibodies OKT3].

The use of OKT3 monoclonal antibodies has improved the immunosuppressive therapy. Due to the high efficiency of this treatment there is an increased risk of overimmunosuppression and occurrence of life-threatening viral infections. Therefore a cautious application of OKT3 is mandatory, a reliable differential diagnosis of the deteriorating graft function essential. In this study the high diagnostic value of urinary neopterin in the early and reliable diagnosis of CMV infection under OKT3 therapy in contrast to serum amyloid A as a marker of rejection could be shown. A differential therapy, supporting or reducing the immunosuppression, might be facilitated by daily monitoring of the neopterin and serum amyloid A.

Adult↗
PubMed1985

Becker muscular dystrophy: carrier detection by real-time ultrasound.

The applicability was tested of real-time ultrasound imaging to the high musculature for the carrier detection of Becker muscular dystrophy (BMD). A total of 17 obligate carriers were examined. Ultrasound images in 3 patients, aged between 46 and 59 years, showed moderate differences compared with the controls. In 3 other obligate carriers, aged between 46 and 71 years, only doubtfully abnormal findings could be made; ultrasound images showed no differences in 11 BMD carriers aged between 10 and 47 years. In women aged over 40 years, compared with adequate controls of the same body type, real-time ultrasound imaging may provide additional evidence and thus help in the detection of BMD carriers.

Adolescent↗
PubMed1981

Automated perimetry in a neuro-ophthalmologic practice.

Visual field examinations were performed with both the Fieldmaster Automated Perimeter and the Goldmann kinetic perimeter on 60 patients, aged 10 to 70 years (118 eyes) referred for neuro-ophthalmologic evaluation. Results suggest that the Fieldmaster perimeter is almost as sensitive as the Goldmann perimeter in identifying abnormal visual fields (99.2%). False-positive results were noted in only two cases (1.6%). Fieldmaster perimetry demonstrated certain advantages over Goldmann perimetry in easily fatigued, inattentive, or uncooperative patients. Recent technological advances in automated perimetry resulting in greater sensitivity and reproducibility of results now offer a viable alternative to Goldmann perimetry.

Adolescent↗
PubMed1977

A-V block.

Explore the source record for details and available documents.

Atrioventricular Node↗
PubMed1976

[Situation definition and its significance for diagnosis, therapy, and rehabilitation].

Diagnostic and therapeutic proceeding involves usually that physician/psychologist became the subject and patient/client the object in a rational process. - Exactly this can cause disturbances of this process, especially in cases of psychosomatic diseases and emotional disturbances. It will be considered (a) whether a more flexible relationship between physican/psychologist and patient/client can be established, (b) whether reflection of the concordance (or discordance) in "defining the situation" leed to new aspects of physicans/psychologists proceeding. (c) Implications for training, methods, therapy and rehabilation will be discussed.

Adolescent↗