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Biomedical subjects

S Scholz

Publications and source records attributed to S Scholz.

At least 19 recordsLinked to original sources
PubMed1979

HLA-A, -B, and -D antigens in paralytic poliomyelitis.

Sixty-two unrelated Caucasian patients from the Munich area who had had paralytic poliomyelitis in the 1950s and the early 1960s were analyzed. HLA-A and -B typing was performed for 26 antigens. HLA-D tying was done using six different established homozygous typing cells defining the specificities Dw1-Dw5 and Dw11, plus one locally defined typing cell. None of the HLA-A, -B or -D determinants showed a significant deviation in frequency from control populations. Of interest may be a decrease of B8 and an increase of Bw16 (Bw38/39) and B27, but these deviations are not significant in their P values are corrected for the number of comparisons made.

Adolescent↗
PubMed1979

[Immunological examination of lymphocytes in patients with sarcoidosis and bronchial asthma (author's transl)].

Blood lymphocytes of 31 patients with bronchial asthma and of 20 patients with sarcoidosis were isolated and investigated for the following surface markers: E-receptors (E-rosettes, a T cell characteristic), Fc-receptors (EA-rosette assay), C3-receptors (EAC-rosette assay), surface immunoglobulins (immuno-fluorescence technique). In addition, the reactivity against allogeneic lymphocytes was tested in mixed lymphocyte culture (MLC). MLC properties were defined by homozygous reference cells (so-called LD-typing). HLA-typing was performed simultaneously. The results, so far, indicate in both disease groups a series of remarkable alterations of the lymphatic subpopulations. A marked diminution of circulating T lymphocytes was encountered in some cases. The immunological results are discussed in relation to pathogenetic aspects of the diseases.

Asthma↗
PubMed1978

HLA--D typing in 72 psoriasis vulgaris patients: distribution of seven HLA--D alleles.

The phenotype distribution of seven HLA--D alleles among 72 unrelated Psoriasis vulgaris patients was investigated. Statistically significant deviation from the antigen frequency in healthy donors was found for a new HLA--D allele, locally designated EI, with a relative risk value of 5.97. This observation indicates that Psoriasis vulgaris belongs to the group of diseases with associations to HLA--B as well as HLA--D alleles.

Alleles↗
PubMed1978

Matching for DLA-A, DLA-B and DLA-D antigens and skin allograft survival in unrelated beagle dogs.

The effect of matching for immunogenetic markers on the survival of skin allografts in unrelated dogs has been studied. Skin grafts in recipients differing from donors for either DLA-A or DLA-B antigens, or both, had mean survival times (MST) of 9.3, 9.7 and 8.5 days, respectively. Differences between these groups were not significant. Prolonged survival of skin grafts, however, was found in SK-LD-indentical (MST: 12.4 days) or SD-identical/LD-different (MST: 12.5 days) donor-recipient combinations. We conclude that dkin allograft survival in dogs appears to be controlled by DLA-A and DLA-B, but not by DLA-D determinants.

Animals↗
PubMed1977

[Long-term therapy using horse anti-dog lymphocyte globulin without sensitization against horse protein].

Eight mongrel dogs received a standard daily i.v. infusion of 20 mg/kg b.w. deaggregated horse-anti-dog-lymphocyte-globulin (ALG) and additional prednisolone (1 mg/kg b.w. daily i.v.) over a maximum period of 82 days following pretreatment with deaggregated normal horse IgG. No sensitization against horse protein was observed during therapy of afterwards as proved by lack of humoral antibodies against horse antigens, maintained lymphopenia, good compatibility, longterm prolongation of xenogeneic skin graft survival (85.6+/-20.6 days, n=8' untreated controls 12.5+/-1.3 days, n=4) and longterm suppression of cytotoxic antibodies against donor lymphocytes. The level of preformed agglutinating antibodies against horse erythrocytes was significantly reduced, while preformed antibodies against other species remained normal. The immune response to a challenge injection of anti-lymphocyte-serum (ALS) 6-11 weeks after termination of treatment was significantly lower in the ALG treated animals as compared to the control group. These results suggest the involvement of a specific mechanism of unresponsiveness against ALG other than immunosuppression only. It is concluded, that by the described method sensitization against ALG can be prevented during longterm treatment.

Animals↗
PubMed1977

Three-point association of HLA-A,B,Bf haplotypes deduced in 200 parents of 100 families.

The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters, and chi-square values were determined both from the genotype and from the phenotype data. Although the HLA-B,Bf associations involve antigens that are also present in the highly associated A,B and B,D haplotypes of the Caucasian population, there was--with the possible exception of HLA-A3,B7,Bf-S--no significant three-point association for HLA-A,B,Bf.

Adult↗
PubMed1977

Kidney transplantation following treatment with cyclophosphamide and bone marrow grafting.

Canine cyclophosphamide (CY) chimeras permanently accept kidney and skin grafts as do radiation chimeras. Three of five dogs with reversion of chimerism rejected their kidney grafts within 11-16 days, while two of them retained their kidney grafts permanently. These results suggest that the reversion of chimerism in CY chimeras may be due to different mechanisms, either immunologic rejection or a nonimmunologic substitution of the grafted marrow by the host's own hemopoiesis.

Animals↗
PubMed1977

HLA-D typing with homozygous lymphoblastoid cell lines.

Lymphoblastoid cell lines (LCL) was established from peripheral blood lymphocytes (PBL) of 2 HLA-DW 3 homozygous siblings. HLA-D typing was performed with the homozygous LCL and PBL in a group of 51 unrelated individuals selected according to their HLA-A,B locus antigens. All the individuals who were typed positive for DW3 with PBL typing cells could also be typed positive with the LCL typing cells. Both homozygous LCL behave very similarly in the tested population. These experiments showed that the same HLA-D determinants were represented both on LCL and PBL cells and that LCL derived from MLC homozygous donors can be used for HLA-D typing.

Cell Line↗