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S Sedlecki

Publications and source records attributed to S Sedlecki.

10 recordsLinked to original sources
PubMed1989

[Incorporation of 3H-cortisol into the dental pulp and the induced changes].

The incorporation of labelled hydrocortisone (3H-cortisol) in the dental pulp of Wistar rats has been tested using autoradiography. Light microscopy showed that an hour after injection the hormone is incorporated in the nuclei of the odontoblasts, subodontoblastic and endothelial cells of the dental pulp. It was also demonstrated at the ultrastructural level that a 4 week-treatment with high rates of hydrocortisone (16 and 32 mg/kg) at the time of rat intensive growth induces degeneration of the odontoblasts, pulp connective tissue cells and capillaries. High rates of hydrocortisone thus induces a decrease in the protective and reparative responses of rat molar pulp.

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PubMedDate not supplied

[Growth of Wistar rats jaws following single dose of vincristine].

In the chemotherapy of malignant diseases the cytostatic Vincristine is often used. Since literature data showed the negative effects of Vincristine on young cells of the healthy developing tissue, only animals were used in experiment of Vincristine testing. The purpose of this investigation was to evaluate the growth of the rat's maxilla and mandible in relation to time intervals following a single dose of Vincristine. The experiment concerned 80 Wistar rats of both sexes. Experimental animals (46) were subcutaneously injected, in the neck wrinkle, a single dose of 0.1 mg/kg BW of Vincristine, on the 7th or 8th postnatal day. The control group consisted of 34 untreated animals. Both treated and untreated animals were sacrificed on the 24th, 42nd and 57th postnatal day, respectively, by decapitation. Following isolation and removal of soft tissue remnants jaws were radiographed using Siemens X-ray dental device. Morphometric measurements were performed with the following parametres: front and rear width and height of the maxillary arc, sagittal and vertical dimensions and coronal length of mandibular incisors. Values were statistically computed and elaborated by Student t-test. The significant level was 5% (p less than 0.05). The results showed that the mean values of the majority of parametres of both jaws were significantly lower in the group of treated animals compared to untreated group.

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PubMedDate not supplied

[Radiation effects on calcium concentration in mice jaws and teeth after administration of whole-body doses of 10 GY].

The investigation concerned sex-mature C57Black male mice. The animals were subjected to whole-body doses of 10 GY. At the same time the bone-marrow transplantation and local application of superoxide-dismutase (SOD) and amino-fluoride (AF) were performed. Calcium concentration in mice jaws and teeth was examined by atomic photospectrometric method. The following results were obtained: GROUP OF X-RAYED MOUSES sacrificed on the 4th day -- 21.17%Ca sacrificed on the 7th day -- 22.01%Ca sacrificed on the 10th day -- 22.45%Ca sacrificed on the 12th day -- 22.51%Ca sacrificed on the 16th day -- 18.50%Ca GROUP OF X-RAYED AND PROTECTED MICE sacrificed on the 5th day AF--21.91; SOD--22.38; AF+SOD--21.55%Ca sacrificed on the 11th day AF--21.55; SOD--20.73; AF+SOD--22.71%Ca sacrificed on the 17th day AF--22.25; SOD--22.94; AF+SOD--21.95%Ca The obtained results showed insignificant differences within the single groups. In the group of X-rayed mice a small and continual increase of calcium concentration from the 4th to the 12th day of sacrifice was evident. Thereafter the calcium concentration suddenly decreased (from 22.51 to 18.50) This did not occur in the group of X-rayed and protected animals. Values of calcium concentration in the control group were similar to those in the other group (22.81).

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PubMedDate not supplied

[Effect of vincristine on molar development and jaw growth in rats].

A cystostatic of group Vinca-alcaloides, Vincristine, is often used in chemotherapy. As a microtubular poison it reacts with microtubular molecules of cell cytoplasma and in response to dose administrated decelerates or stops cell division. Since the information about the effect of this drug on molar teeth has not been found in available literature the aim of this study was to investigate the effect of vincristine on tooth development and jaw growth in rats. The experiment was carried out on Wistar rats of both sexes. Vincristine (Oncovin, "Lilly") was injected to animals in the dose of 0.1 mg/kg b.w. seven or eight days following birth. Treated and control animals were sacrificed on the 24th postnatal day. Radiographs of the mandibule were used to study tooth development. The morphometric examination concerned the following parameters: in maxillar frontal and posterior arc width and height; vertical and sagital dimension as well as length of incisive crown in the mandibule. The results of the analysis suggested that the teeth of treated rats were retarded in development compared to the control animals. Morphometric investigations showed that in treated rats both jaws were decelerated in growth in comparison to the control group but with no statistical significance. It should be emphasized that a 16-day-period was too short that full efficet of Vincristine should be established in rats and lead to a result which could suggest a certain molar development and jaw growth.

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