[HIT II in the intensive care unit].
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Anticoagulants↗
Biomedical subjects
S Seemann
Publications and source records attributed to S Seemann.
Hospital-wide intravenous initiative.
During a 6-month period under the leadership of a clinical nurse specialist, a Midwestern tertiary care hospital explored the need for standardizing a hospital-wide intravenous infusion system, based on best practice. The Center for Advanced Nursing Practice's Evidence-Based Practice Model guided the process for successful design, implementation, and reporting of results. The new system contributed to positive outcomes identified in project goals: (1) to minimize patient risk from interruption of intravenous lines; (2) to increase clinician satisfaction by improved user safety and system standardization; and (3) to demonstrate responsible organizational financial stewardship. Ultimately, the standardized hospital-wide intravenous initiative empowered bedside clinicians by providing an infrastructure for best practice.
Education, Nursing, Continuing↗
Interdisciplinary approach to a total knee replacement program.
An orthopedic clinical nurse specialist facilitated an interdisciplinary evaluation, design, and implementation of best practice initiatives for the total knee replacement patient population using the Center for Advanced Nursing Practice's Evidence-Based Practice Model. The interdisciplinary team approach enhanced the total joint program by achieving positive patient outcomes, demonstrating financial stewardship of resources, and facilitating inter- and intradisciplinary communication.
Anticoagulants↗
The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.
We describe the isolation and characterization of the cDNA for FKHL13, the human homologue of the mouse hepatocyte nuclear factor 3/fork head homologue 4 (HFH-4) gene, a member of the HNF-3/fork head (also called winged helix) gene family. Members of this gene family contain a conserved DNA binding region of approx. 110 amino acids and are thought to play an important role in cell-specific differentiation. Previous analysis of the mouse and rat HFH-4 cDNAs revealed a distinct pattern of expression for this gene, suggesting that the gene plays an important role in the differentiation of lung and oviduct/ampulla epithelial cells and testicular spermatids. Analysis of the human FKHL13 gene confirmed this pattern of expression. We also found expression in adult human brain cortex, which we were able to confirm for the mouse. The expression pattern of FKHL13/HFH-4, confined to cilia/flagella-producing cells, leads us to believe that the gene plays an important role in the regulation of axonemal structural proteins. We show that the human gene for FKHL13 lies on chromosome 17 (comparison with the chromosomal location of the mouse gene strongly suggests 17q22-q25) and that the gene, which is approx. 6 kb, contains a single intron disrupting the fork head DNA binding domain. Such a disruption of a functional unit provides strong evidence for the theory of intron insertion during gene evolution. The expression of the gene is probably controlled by the CpG island, which is located in the promoter region of the gene. We also demonstrate that the FKHL13 gene is highly conserved among a wide variety of species, including birds.
Adult↗
[Women physicians in a surgical university clinic 1980 to 1996].
From 1980 to 1996 214 male and 51 female physicians were employed at the Department of Surgery of the University Hospital of Lübeck (Germany). The percentage of female surgeons increased from 13% in 1980 to 20% in 1996. Nowerdays female surgeons more often succeed in becoming a specialist, a ward physician or senior physician. Female physicians often quit their job in surgery because of reasons in their family background (child care, change of place of their husband's job).
Career Choice↗
Blood sample collection from a peripheral catheter system compared with phlebotomy.
Hospital experiences often are punctuated with pain related to common procedures, such as venipuncture. An alternative to venipuncture involves obtaining samples from an existing peripheral vascular saline lock device. To validate such a collection, this study compared the accuracy of serum chemistry tests performed on samples taken concurrently from the saline locks and by phlebotomy. No clinical differences were noted within the 17 sets of ion assays, and both potassium and chloride determinations demonstrated no significant statistical differences between the sample groups. Documented rates of sample hemolysis (21%) and difficulties experienced in collection suggest that blood sampling from an existing peripheral saline lock device is best suited to inpatients undergoing multiple blood sampling necessitated by short-term investigative procedures or crisis management.
Blood Chemical Analysis↗