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Biomedical subjects

S Seewald

Publications and source records attributed to S Seewald.

14 recordsLinked to original sources
PubMed1996

Activation of Na+/H+ exchanger is not involved in the PDGF-BB-induced DNA-synthesis in vascular smooth muscle cells.

HOE 694 [(3-methylsulphonyl-4-piperidinobenzoyl)guanidine methanesulphonate] was characterized as a new, potent, non-amiloride inhibitor of the Na+/H+ exchanger. In order to elucidate whether the Na+/H+ exchanger isoform 1 (NHE-1) is involved in the PDGF-BB-induced DNA-synthesis in vascular smooth muscle cells, we investigated the effect of HOE 694 and EIPA on the PDGF-BB-induced DNA synthesis. EIPA (10 microM) inhibited the PDGF-BB-induced stimulation of the Na+/H+ exchanger and the PDGF-BB-induced DNA synthesis in a concentration-dependent manner. HOE 694 (1-50 microM) dose-dependently inhibited the PDGF-BB-induced stimulation of the Na+/H+ exchanger but had no significant effects on DNA-synthesis. Our findings suggest that activation of the Na+/H+ exchanger is not essential for PDGF-BB-induced vascular smooth muscle cell growth.

Amiloride↗
PubMed1995

[Orthostatic hypotension].

We report about a 67-year-old woman presenting with progressive orthostatic vertigo, urinary incontinence and clinical signs of Parkinson's disease. The Schellong test revealed deficient sympathetic orthostatic pressure response without an increase of plasma norepinephrine; therefore, a Shy-Drager syndrome was diagnosed. Because of inefficiency of the general measures (compressive pantyhose), the sympathomimetic agonists, and the centrally active alpha-2-antagonists, norepinephrine was administered via a miniature dosing pump. By this therapeutic regimen a marked improvement of orthostatic hypotension was achieved.

Aged↗
PubMed1995

[Turbo-spin-echo (TSE) sequences with selective fat suppression (SPIR) compared with chemical shift sequences in MRI for differentiation of adrenal tumors. Spectral Presaturation by Inversion Recovery].

AIM: The value of chemical-shift-gradient-echo sequences and turbo-spin-echo sequences with selective fat suppression (SPIR = Spectral Presaturation by Inversion Recovery) in the differentiation of benign and malignant adrenal tumours was investigated. METHODS: Both techniques were performed at 1.5 T in 22 patients with 24 tumours. The loss of signal intensity of the tumour or of the signal intensity ratio between tumour and liver or muscle on the opposed phase Fast-Field-Echo (FFE) sequence in comparison to the in phase FFE sequence or on the TSE-SPIR sequence compared to the TSE sequence was the criterion for intratumoral lipid, suggesting a benign mass. RESULTS: The sensitivity and specificity of the chemical shift technique was 62-77 and 100%, respectively. In adrenal tumours larger than 1.5 cm sensitivity of the chemical-shift technique was 89%. On the contrary sensitivity of the TSE-SPIR sequence was only 11-78%. Both techniques had a specificity of 100%. CONCLUSION: The chemical shift technique is more accurate in the differentiation of adrenal masses than the TSE-SPIR sequence.

Adenoma↗
PubMed1995

Native low-density lipoprotein (LDL) induces the expression of the early growth response gene-1 in human umbilical arterial endothelial cells.

Low-density lipoprotein (LDL) is thought to be involved in the growth of various cell types including human endothelial cells. Nevertheless, little is known about the signal transduction mechanisms underlying the growth-promoting effects of LDL in endothelial cells. Furthermore, the question whether native LDL participates in the described effects remains unanswered. Here, we show that native LDL induces a dose-dependent elevation in free intracellular Ca(2+)-concentration ([Ca2+]i) as well as a rapid and prolonged increase in intracellular pH (pHi) in human umbilical arterial endothelial cells (HUAEC). Native LDL induces a dose-dependent increase of early growth response gene-1 (egr-1) mRNA expression. The effect is maximal 30 min after addition of LDL to the culture medium. Moreover, native LDL causes an increase in DNA-synthesis and cell proliferation. In addition, the effect of acidic fibroblast growth factor (aFGF) on HUAEC proliferation was enhanced by native LDL.

Calcium↗
PubMed1994

[Abdominal pain, weight loss, tarry stools].

A 65-year-old man had abdominal pain and night sweat for several weeks. He had lost weight and also reported black stools. Anemia of iron deficiency was found in laboratory tests. Further investigation revealed a stenosing process in the small intestine as source of bleeding. High grade non-Hodgkins' lymphoma was diagnosed histologically in the resected bowel segment and the mesenteric lymph nodes. Further staging did not reveal further manifestations of lymphoma. Polychemotherapy and subsequent irradiation were administered.

Abdominal Pain↗
PubMed1994

[Cough, vomiting, rapid weight loss].

A young male patient from Somalia presented with a productive cough since a few days, and he complained about vomiting after meals and a rapid loss of weight of 20 kg. Endoscopic, radiological and clinical examinations revealed a broncho-esophageal fistula. Further examinations showed mycobacterium tuberculosis as the underlying cause of the disease; a malignancy was excluded. Antituberculous treatment resulted in the loss of the present symptoms as well as in a clinical and endoscopic closure of the fistula.

Adult↗
PubMed1994

[Bone pain, polydipsia, polyuria].

This 20 year old man suffered increasingly from multifocal bone- and back pain over the last 6 months. Painful weakness of the left leg with dysesthesia of the 4th and 5th toe, a weight loss of 15 kg and polydipsia and pollakiuria had developed. The clinical workup disclosed hard tumors in the right mandible and tibia, a waddling gait with bilateral sign of Trendelenburg, reduced muscular force in the left leg with missing achilles tendon reflex and a loss of sensibility in the distal S1 segment, epigastric tenderness on pressure and hypertension with a value of 160/100 mmHg. X-rays revealed multiple cystic bone lesions at all sites. Hypercalcemia and massively elevated parathyroid hormone were measured. Since the parathyroids were enlarged on sonography, primary hyperthyroidism with fibrosing osteitis v. Recklinghausen was diagnosed.

Adenoma↗
PubMed1994

[Headache].

This 46 year old man complained for the first time five years ago about stinging bilateral occipital headache while in prone or horizontal position and disappearing completely in the supine position after a few minutes. Two years ago hypertension with values up to 240/140 mmHg was discovered on a routine examination. For the past six months the patient complained about sudden attacks with headache, hammering pulse, nausea, pallor, sweating and blood pressure values of 200/100 mmHg. A pheochromocytoma measuring 7 x 8 cm was diagnosed on the left side and removed subsequently.

Adrenal Gland Neoplasms↗
PubMed1994

Iron-deficiency anemia as the sole manifestation of celiac disease.

We report on a 40-year-old woman with a 2-year history of iron-deficiency anemia of unknown origin. Repeated endoscopic investigations in the past had revealed no abnormality of the gastrointestinal system on macroscopic examination. Oral iron supplementation was shown to have no effect on serum iron levels and had no influence on the anemia. Upper gastrointestinal endoscopy performed at our hospital confirmed normal macroscopic findings. However, jejunal biopsies revealed subtotal villous atrophy of the mucosa of the small intestine. A strict gluten-free diet led to an increase in serum iron, resolution of the anemia, and restitution of normal mucosal architecture. Thus iron-deficiency anemia may be the lone manifestation of celiac disease.

Adult↗
PubMed1994

Solitary retinal granuloma as a presenting sign of sarcoidosis.

A 31-year-old white patient was referred with a recent history of decreased visual acuity in his left eye. A raised, greyish-white lesion close to the optic nerve was the only ophthalmological finding. Upon systemic work-up a chest X-ray revealed enlarged pulmonary lymph nodes. A biopsy obtained during bronchoscopy led to the diagnosis of sarcoidosis. No other manifestation was noted. Following systemic steroid treatment the lesion regressed and visual acuity improved. Granulomatous inflammatory diseases have to be ruled out in cases of prominent greyish-white fundus lesions.

Adult↗
PubMed1993

[Muscle weakness].

A 61 year old man complained initially about pain in the left lower leg with increasing swelling of the entire left leg. A slight swelling of the left ankle and knee and an erythematous skin change of 5 cm diameter developed and disappeared after a few hours. Two days later the patient complained about a sudden and massive weakness of the proximal skeletal muscles, progressive disturbance of swallowing, hoarseness and dark red to bluish erythematous skin eruptions on the right knee and buttock. An elevated creatinine-kinase and lactate-dehydrogenase were found. Dermatomyositis was diagnosed and treatment with high dose steroids initiated. Under this treatment the patients condition deteriorated dramatically. A treatment with plasmapheresis and cyclophosphamide was begun. A significant improvement occurred over three weeks. The patient was discharged, rehabilitated and remains free of symptoms on 10 mg cortisone. A neoplasm has so far not been detected.

Acute Disease↗
PubMed1993

[Diarrhea].

A 54-year-old man had recurrent watery diarrhea with up to 10 stools per day for 4 years. The initial evaluation including coloscopy did not disclose a pathologic finding. The symptoms subsided initially after four weeks. Three years later massive watery diarrhea recurred with up to fifteen daily stools. A reevaluation of the patient disclosed the diagnosis of collagen colitis in the colonic biopsy.

Colitis↗
PubMed1993

[Back pain].

This 54 year old male patient complained of upper back pain for four months, which increased on physical exertion. An X-ray examination of the spine showed compression fractures of the anterior aspects of the thoracic vertebrae VI and XI as well as anterior aspects of the thoracic vertebrae VI and XI and signs of osteoporosis. Physical examination revealed signs of hypogonadism as well as eunuchoid disproportions of the skeleton. Serum tests gave evidence of a hypogonadotropic hypogonadism due to isolated LH-secretion deficiency (Pasqualini syndrome) with secondary osteoporosis.

Back Pain↗