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Biomedical subjects

S Shimosato

Publications and source records attributed to S Shimosato.

At least 19 recordsLinked to original sources
PubMed1986

Circulatory effects of atracurium in patients with cardiovascular disease.

Atracurium 0.4 mg kg-1, which was sufficient to produce neuromuscular blockade sufficient for intubation, was administered as divided bolus doses to 40 patients with severe cardiovascular disease. Little haemodynamic change occurred. A transient reduction in arterial pressure was noted in one patient. Atracurium was found to be safe and effective, and administration in small bolus doses separated by 30 s may reduce the likelihood of significant circulatory changes.

Anesthesia, General↗
PubMed1979

Cardio-circulatory effects of enflurane anesthesia in health and disease.

The circulatory effects of enflurane (Ethrane) were studied in 10 unmedicated volunteers during anesthesia over a period of 90 min or more. Cardiac output did not change significantly at a mean alveolar concentration of 2.3 vol.%. Heart rate was increased in all cases. Enflurane causes negative inotropic activity in the heart muscle but has little influence on the pump performance of the heart.

Anesthesia, Inhalation↗
PubMed1978

Cardiac performance during prolonged halothane anaesthesia in the cat. Isolated heart muscle study.

The contractile response of papillary muscles, isolated from normal cats, to prolonged administration of halothane at minimum alveolar anaesthetic concentration (MAC) was studied. Average values of maximal velocity of shortening (Vmax) and maximal developed force (Fm) obtained in 12 muscles during the 1st, 2nd and 3rd hour of exposure to halothane anaesthesia were significantly less than those obtained during the control period and after recovery from halothane. There were no significant differences in values over a 3-h period. When post-extra-systolic potentiation was induced by paired electric stimulation, average values of Vmax and Fm increased significantly. We conclude that prolonged administration of halothane at a constant concentration resulted in a sustained depression of myocardial contractility without tissue tolerance. The myocardium depressed by halothane, however, still retains the ability to respond to additional inotropic stimulation.

Anesthesia, General↗