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Biomedical subjects

S Sievers

Publications and source records attributed to S Sievers.

At least 19 recordsLinked to original sources
PubMed1984

[The progestasert system--a 24-month-long active spiral. Clinical experiences with an intrauterine progesterone-releasing system].

The Biograviplan (IUD) is a therapeutic system which, from a reservoir of 52 mg progesterone, permits the programmed release of the hormone within the uterus. It provides effective contraception over a period of 24 months. Spotting, intensified and prolonged menstrual bleeding can, in common with other IUDs, occur initially. Later, hypomenorrhoea and, occasionally, also silent menstruation extending over up to 3 cycles, can be seen. Dysmenorrhoea and menstrual pain are markedly reduced as compared with other IUDs. No intrauterine pregnancy was observed, but several extrauterine pregnancies occurred. Patients should be carefully selected for such a device, which can be recommended in particular for women with primary dysmenorrhoea or hypermenorrhoea.

Adolescent↗
PubMed1983

[Management of pregnant women with thalassemia minor].

Owing to the fact that Germany has become the domicile of a great number of aliens from Mediterranean countries, an increasing number of thalassaemia cases have been reported and given cause for a thorough investigation. Since thalassaemia minor is a hereditary disease, a special prophylaxis has to take place in case of pregnancy: 1. examination of child's generator, 2. genetic counselling, 3. embryoscopy and extraction of embryonic blood, 4. if thalassaemia is diagnosed, an abortion should be taken into consideration.

Adult↗
PubMed1981

[Adhesion prophylaxis in surgical gynecology].

In operations near the internal genitalia it is important to prevent adhesions if fertility is to be preserved. As animal experiments and clinical experience have shown a fibrinolysin can be use for prevention of adhesions. In operations on the tube for restoring fertility and during chromolaparoscopy one should use a fibrinolysin, or example Varidase, and a cortisone derivative.

Anti-Bacterial Agents↗
PubMed1981

[A report about 311 ovarian carcinomas, treated at the "Universitäts-Frauenklinik des Klinikums Mannheim der Universität Heidelberg" from 1960--1978 (author's transl)].

In the medical histories no hints could be found, suggesting a definite risk-group for ovarian carcinoma. Symptoms and complaints are often uncharacteristic and no methods for early recognition are known. The therapy of the ovarian cancer is an operation, combined with chemotherapy, or radiation considering to the stage of the tumour. Most important for the prognosis is the degree of expansion, besides age of the patients and the histological pattern of the tumour. The three-years-survival rate of our patients with stage T1 is 71,7%, and with stage T4 only 13,5%. Above all advance in early diagnosis it is necessary to achieve higher survival rates.

Adolescent↗
PubMed1981

[The prognosis of malignant ovarian tumours in correlation to the histological findings (author's transl)].

The prognosis of malignant ovarian tumours depends upon the stage at the onset of treatment when the histology is similar and in tumours of the same stage upon the histologic type of tumour. Ovarian cancers were histologically divided into 7 groups. The diagnosis in our series allowed to consider the following groups: Germinal cell tumours (group 1), tumours arising from isolated epithelial rests (group 2), tumours of follicular cell origin (group 3), tumours of the covering epithelium (group 4), and genetically indeterminate tumours (group 6). The stage T1 at the onset of treatment was most frequently diagnosed in tumours arising from follicular cells (61%). Tumours arising from the covering epithelium or genetically indeterminate tumours showed stage T1 in 15 or 16%. Secondary tumour at the onset of therapy was found in increasing frequency from group 1 to group 6. The survival rate decreases from group 1 to group 6. The worst prognosis show patients with genetically indeterminate tumours, followed by patients with malignant tumours of the covering epithelium. The best survival chance have patients with tumours of the germinal epithelium. It is therefore important to plan the post-operative treatment not only according to the stage of tumour but also according to the microscopic findings.

Adolescent↗
PubMed1979

[The treatment of pre-malignant hyperplasias of the endometrium with progesterone-carrying intra-uterine devices (author's transl)].

The local administration of progestional agents for the treatment of adenomatous hyperplasia of the endometrium is insufficient for two reasons: 1. The locally applied progestational agent does not reach the total surface of the endometrium especially not in the uterine fundus or in the tubal cornua. This is frequently due to uterine myomata and to the T-shape of the intra-uterine device which does not contain progestational agents within the T. 2. The progestational agent released by the intra-uterine device does not reach the deeper layers of the endometrium. It is therefore possible that the deeper layers of the endometrium undergo malignant change. At present it is therefore necessary to administer progestational agents in the treatment of adenotamous hyperplasias of the endometrium systemically.

Endometrial Hyperplasia↗
PubMed1979

[Microscopic, micro-chemical and fluorescent optical findings in endometrium with a copper-T intrauterine device in situ (author's transl)].

The uteri of ten patients who wore a copper-T for several months up to two years were examined immediately following hysterectomy by conventional microscopic techniques, fluorescent optical techniques after Acridin-Orange-Fluorochromization and by histo-chemical techniques for copper. With none of these methods changes in the endometrium could be found which explained the effect of the copper-T to inhibit implantation. Since practically any morphological change from the normal was absent it is suggested that the inhibiting effect on pregnancy of the copper intra-uterine devices is due to biochemical changes of the intra-uterine environment.

Adult↗
PubMed1978

Localization of glycosyl transferases in plasma membranes from Dictyostelium discoideum.

Crude membranes from vegetative and aggregation competent cells of Dictyostelium discoideum Ax 2 were separated by a combination of differential and sucrose gradient centrifugation. A fraction mainly containing plasma membranes could be isolated. The high degree of purity was demonstrated by electron microscopy and by the presence of marker enzymes typical for the plasma membrane and the absence of enzymes characteristic for other subcellular compartments. Furthermore surface labelling with radioactive 1--fluoro--2,4--dinitrobenzene--14C and cAMP binding capacity were introduced as plasma membrane markers. In the pure plasma membrane fraction endogenous activities of D--mannosyl-, D--glucosyl- and N--Acetyl--D--glucosaminyl--transferases were present. The activities in plasma membranes of aggregation competent cells were up to thirty times higher than in membranes isolated from vegetative cells.

Acid Phosphatase↗
PubMed1978

[The effects and side-effects of the intra-cervical application of prostaglandin F-2 alpha during early pregnancy (author's transl)].

In order to avoid the traumatic dilatation of the cervix for therapeutic abortions 200 micrograms of prostaglandin F-2 alpha were injected into the cervix. The effect on dilatation of the cervix was compared with the injection of normal saline in the control group. Without side effects the injection of prostaglandin F-2 alpha resulted in dilatation of the cervix and softening of the cervix. Normal saline had no effect. At present it is unknown whether the dilatory effect of prostaglandin F-2 alpha on the cervix is local or secondary to uterine contractions.

Abortion, Legal↗