Biomedical subjects
Publications and source records attributed to S Sikdar.
Systemic effects of betel quid are poorly documented compared to its local effects on the mucosa of the oral cavity and pharynx. In the present study dysplastic activity of the betel quid on exfoliated uterine cervical cells was studied and compared with women addicted to other habits or nothing. That the mutagenic changes at cellular level are associated with prolonged use of betel quid is suggested.
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The human immunodeficiency virus (HIV) pandemic is nearly 20 years old. HIV infection is characterized by profound immunodeficiency resulting in an increased incidence of opportunistic infections and neoplasms. However, the greatest paradox is the occurrence of certain autoimmune disorders in the setting of HIV. These include diffuse interstitial lymphocytosis syndrome (DILS), reactive arthritis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). It has also been seen that even in the absence of these well-defined diseases, various rheumatological manifestations such as arthralgias, arthritis, myopathy, vasculitis, and sicca syndrome are commonly associated with HIV. To the best of our knowledge, the association of HIV with scleroderma has not previously been reported.