Biomedical subjects

S Skurtveit

Publications and source records attributed to S Skurtveit.

14 recordsLinked to original sources

PubMed2004

Characteristics of drivers testing positive for heroin or ecstasy in Norway.

An increasing number of heroin and ecstasy seizures were recorded by the Norwegian police and customs authorities in the 1990s. The number of apprehended drivers in whom heroin and ecstasy were detected also rose in the same period (Heroin, 1991: n = 17, 1999: n = 320. Ecstasy, 1995: n = 6, 1999: n = 123). Drivers who tested positive for heroin (detected in urine as the metabolite 6-monoacetyl-morphine, 6-MAM) or ecstasy (3,4-methylenedioxy-metamphetamine, MDMA, detected in blood) were characterized with regard to age distribution, drug use pattern, and earlier arrests. In 1998-1999, the police apprehended 9013 drivers on suspicion of being under the influence of drugs other than alcohol. Blood and urine samples from the drivers were sent to the Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse and analyzed for the most commonly abused drugs. 6-MAM was detected in urine in 7% of the cases (n = 637), representing 542 different drivers (male: 85%, n = 463, female: 15%, n = 79) as some drivers were rearrested several times during the selection period. MDMA was detected in 2% of the cases (n = 190), representing 177 drivers (male: 90%, n = 160, female: 10%, n = 17). The median ages of drivers who tested positive for 6-MAM or MDMA were 32 and 24 years, respectively. Multi-drug use was very common in both groups (83% and 98% for the heroin and ecstasy group, respectively). Drivers in both groups were followed back to 1985 to detect earlier arrests for the same offence. Of the heroin group, 78% (n = 417) had earlier been arrested for drunken or drugged driving. Alcohol was the drug most frequently detected on first arrest. Of the ecstasy group, 47% (n = 83) had earlier been arrested, and amphetamine was most frequently found on first arrest.

Adult↗

PubMed2004

Undertreatment and overtreatment with statins: the Oslo Health Study 2000-2001.

OBJECTIVE: We examined the prevalence and factors associated with use of cholesterol-lowering statins in the population. METHODS: Demographic, medical, anthropometric and lifestyle data was obtained from 6233 men and 7521 women born in 1924/25, 1940/41, 1955 and 1960 that participated in the Oslo Health Study 2000-2001. A nonfasting blood sample was collected. RESULTS: Of subjects with a heart attack, angina, stroke or diabetes 45% of men and 35% of women were taking a statin (P < 0.001). Of subjects with cardiovascular disease (CVD) or diabetes taking statins 61% of men and 40% of women achieved total serum cholesterol levels < or =5 mmol L(-1). The odds ratio for taking a statin was increased amongst subjects who also took antihypertensive drug(s) or acetylsalicylic acid, subjects with a family history of coronary heart disease (CHD) and women who had visited the general practitioner within the last year. Amongst presumed healthy subjects use of statins increased from about 1% in women aged 40-45 years, to 7% at age 60 and to 12% at age 75 whilst the corresponding figures for men were 3%, 8% and 9%, respectively. About 22% of men but <2% of women aged 60 who were not taking statins had a 10-year Framingham CHD risk score >20%. Determinants of statin use were similar to those amongst subjects with CVD or diabetes. CONCLUSION: People with CVD or diabetes remain undertreated with statins, women more so than men. Use of other preventive drugs, the family history and recent contact with the general practitioner were the most important determinants of statin use in primary and secondary prevention. Amongst healthy subjects aged 60 or 75 years women received statins disproportionately to their low CHD risk compared with men.

Adult↗

PubMed2002

Rearrest rates among Norwegian drugged drivers compared with drunken drivers.

The rearrest rates among Norwegian drugged (n=1102) and a group of drunken drivers (n=850) (BAC: 0.16-0.19%) apprehended during 1992, were 57% (n=629) and 28% (n=238), respectively, when followed prospectively for 7 years. The most important risk factors for recidivism among drugged drivers were previous arrests for drugged or drunken driving (rearrest rate among previous arrests: 73%, no previous arrest: 42%), multi-drug detection at selection (multi-drug: 62%, single drug: 41%), sex (male: 61%, female: 35%) and age (below 36 years: 60%, 36 years and older: 44%). Most of the recidivist drugged drivers were rearrested during the year of selection (21%), followed by 13, 7 and 6%, retrospectively, during the following years. When followed both retrospectively and prospectively for a period extending from 1984 to 1998, 71% (n=779) and 40% (n=344) of the selected drugged and drunken drivers, respectively, were arrested two or more times.

Adolescent↗

PubMed2001

[What are the associations between occupational physical activity and overweight?].

BACKGROUND: The increasing trend for obesity, together with reduced occupational physical activity in Norway, led us to study the association between work activity and body mass index. MATERIAL AND METHODS: We analysed data from population screenings in Norwegian counties 1974-97. Occupational physical activity was measured by a question with four alternative answers. RESULTS: Among women, sedentary or light physical work was associated with the lowest body mass indices and heavy physical work with the highest. Among men, occupational physical activity was associated with a slightly higher body mass index in general, but not in all counties and not in men who were physically inactive in their leisure time. In the survey in Nord-Trøndelag 1995-97 the body mass index in men was lower in those with physical work than in those with sedentary occupations. INTERPRETATION: The inverse association between physical work and overweight does not indicate an important role of physical work in weight control of women. In men, several explanations are possible. One interpretation is that physical work is of importance for weight control in some rural areas and in men with physical activity in their leisure time.

Adult↗

PubMed2001

[Trends when it comes to occupational physical activity among Norwegians aged 40-42 years during the period 1974-94].

BACKGROUND: The increasing occurrence of obesity in Norway led us to study trends in occupational physical activity. MATERIALS AND METHODS: Population health screenings were conducted in three mainly rural Norwegian counties 1974-88, in all counties except Oslo 1985-94, and in a broad age group in Nord-Trøndelag 1995-97. The National Health Screening Service measured occupational physical activity by a question with four alternative answers, reflecting sedentary, light, moderate or heavy physical work. RESULTS: In the 1970s, 20-26% of 40-year-old men in three predominantly rural counties reported sedentary work, increasing to 30-40% in the 1990s. Among women there was a similar increase from 10% to approximately 30%, while light physical activity decreased from near 70% to 50%. Heavy physical work decreased from 20-30% to 15% among men and from less than 10% to less than 5% among women. Heavy physical work was most common in rural areas. The survey in Nord-Trøndelag showed that differences by age were small in adults beyond 64 years age. Sedentary work was associated with the lowest rates of smoking, and heavy physical work with less good health. INTERPRETATION: Occupational physical activity was markedly reduced in middle-aged Norwegian men and women from 1974 to 1994.

Adult↗

PubMed2000

[Centrally acting muscle relaxants and traffic hazards].

BACKGROUND: An increasing number of the centrally acting muscle relaxants were withdrawn from the Norwegian market during the 1988-98 period. The only drug in this group now marketed in Norway is carisoprodol. The National Institute of Forensic Toxicology in Norway analyses all blood samples from suspected drugged drivers. In later years there has been a marked increase in the number of blood samples testing positive for carisoprodol or meprobamate (the major metabolite). MATERIAL AND METHODS: 480 cases testing positive for central muscle relaxants in the years 1984-1998 were further studied. RESULTS: Compared with blood samples positive primarily for benzodiazepines, there were more women in the group (39% vs. 15%), and fewer drugs and less alcohol were detected. INTERPRETATION: The positive samples may indicate misuse or abuse due to the fact that high drug concentrations and concomitant use of benzodiazepines were frequent. This knowledge should have implications for doctors prescribing centrally acting muscle relaxants.

Accidents, Traffic↗

PubMed2000

Lack of crosstolerance between morphine and morphine-6-glucuronide as revealed by locomotor activity.

Morphine-6beta-glucuronide is a major metabolite of morphine. We wanted to examine whether the effects related to opiate CNS stimulation could be mediated by different receptors for morphine and M6G by studying the development of crosstolerance between these two drugs. The effect studied was locomotor activity in C57BL/6JBom mice. We observed a dose-dependent development of tolerance to daily injections of morphine, with 20 micromol/kg giving the most rapid development of tolerance, apparent already on the second day of treatment. This was also observed for the same dose of M6G. Crosstolerance to M6G was measured both after 1 day pretreatment and 7 days pretreatment with morphine 20 micromol/kg, while the crosstolerance to morphine was tested only after 1 day pretreatment with M6G (20 micromol/kg). Lack of crosstolerance towards M6G after 1 day of morphine pretreatment was observed, whereas crosstolerance to M6G was observed after 7 days of exposure to morphine pretreatment. Crosstolerance after M6G pretreatment to morphine was observed. It was concluded that the main part of the effect caused by M6G was mediated through a specific M6G receptor.

Animals↗

PubMed1999

[Detection of zopiclone in many drivers--a sign of misuse or abuse].

In 1998 zopiclone had a 42% share of the prescribed hypnotic drug market in Norway. The National Institute of Forensic Toxicology analyses all blood samples from suspected drugged drivers. The rise in zopiclone prescription was partly reflected in an increase in the number of drivers with zopiclone detected in the blood. We looked closer at the test results from 101 drivers with zopiclone detected in their blood in the January 1994 to April 1999 period. 60% had blood concentrations of zopiclone above the concentration observed after intake of therapeutic doses; 80% had higher blood concentrations than those expected 8 hours after intake of therapeutic doses. The majority of the drivers also tested positive for illegal drugs, prescription drugs with abuse potential, or alcohol. This indicates that zopiclone is misused or abused. Therefore the same caution should be applied when prescribing zopiclone as is applied when prescribing e.g. benzodiazepines.

Automobile Driving↗

PubMed1999

[Repeated driving under influence].

Many drivers arrested for driving under the influence have earlier been arrested and convicted for a similar type of violation. The article reviews Norwegian studies on car drivers influenced by alcohol, other drugs than alcohol, and also drivers influenced by amphetamine. The results show that between 10 and 30% of drivers convicted for driving under the influence of alcohol, are rearrested two or more times for the same violation during a subsequent three year period. The recurrence rate is dependent on blood alcohol concentration at the selection time. The recurrence rate among drivers under the influence of drugs other than alcohol is significantly larger (up to 54%), when studied over the same three year period. The number of drivers influenced by amphetamine has increased dramatically during recent years. The recurrence rate among drivers influenced by amphetamine is on part with that of drivers using other drugs than alcohol. There are indications that an increasing number of drunken drivers have changed their abuse pattern during recent years from alcohol to illegal drugs such as amphetamine.

Alcohol Drinking↗

PubMed1998

Study of rearrests for drunken driving in Norway.

The National Institute of Forensic Toxicology (NIFT) in Oslo receives blood samples from all Norwegian drivers suspected of driving under the influence of alcohol. It is well known that a large proportion of the arrested drunken drivers are repeat offenders. The purposes of this investigation was to find the arrest rates (the percentage of subjects arrested once or more) among drunken drivers followed retrospectively and prospectively during the 11-year period 1984-1994 and the probability of 'abstaining' from becoming a recidivist during the 9 years subsequent to the year of selection. By examining the rearrest rates during the 3 following years for drivers selected in 1986, 1989, 1991 and 1992 we tried to look for major effects due to the change in the Norwegian road traffic act of 1988. Altogether 45% of the selected drunken drivers were arrested two or more times. Totally the '9-year survival rate' (i.e. not being rearrested) was 60% for drivers with blood alcohol concentration (BAC) selected from the interval 0.06-0.09%; 56% from BAC 0.13-0.16% and 51% from 0.26-0.29%. The data were further evaluated with respect to frequency of rearrest during 3 years after selection, and was around 30% in 1986, while it was lower for drivers selected in 1992 (19%). An explanation for the reduction in rearrest rate may be the changes in the road traffic act which took place in 1988.

Adolescent↗

PubMed1998

Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors.

Morphine-6beta-glucuronide is a major metabolite of morphine with potent analgesic actions. To explore the importance of this opiate when administered as a drug by its own or in morphine action, we studied the locomotor activity response to morphine and morphine-6-glucuronide in drug-naive C57 BL/6JBom mice. The effects of administration of the two opiates on a battery of 7 different locomotor activities were studied and compared to saline controls. A dose of 20 micromol/kg morphine-6-glucuronide resulted in more locomotion than the same dose of morphine, while at higher doses (up to 120 micromol/kg), similar increases for most locomotor behaviours were recorded for both drugs. Pretreatment with naltrindole indicated that the delta-receptors play an equivalent but minor role in mediating both morphine-6-glucuronide and morphine hyperlocomotion. Administration of high naltrexone doses (10 mg/kg) completely abolished the locomotor stimulation induced by both opiates. However, at intermediate naltrexone doses of 0.25 and 0.5 mg/kg, morphine-induced behaviours was completely inhibited while morphine-6-glucuronide induced behaviours demonstrated partial resistance to naltrexone inhibition. The mu1-specific receptor antagonist naloxonazine caused 75% reduction of morphine induced behaviours and only 50% inhibition of morphine-6-glucuronide induced behaviors. Taken together our observations indicated general similarity but also marked differences between morphine and morphine-6-glucuronide with respect to opiate receptors mediating the locomotor stimulatory effect.

Analgesics, Opioid↗

PubMed1996

Recidivism among drunken and drugged drivers in Norway.

The prevalence of re-arrest among drunken drivers in relation to different blood alcohol concentrations (BAC) at the time of the offences was studied. Between 38 and 50% of arrested drunk drivers were re-arrested for similar offences. The frequency of re-arrests was, however, reduced during 1992 compared with a986, but only significantly for those with a low BAC interval (60-90 mg/d). We conclude that drivers with high re-arrest rates have a careless attitude to the Road Traffic Act and require a different treatment and follow-up programme.

Accidents, Traffic↗

PubMed1995

Female drivers suspected for drunken or drugged driving.

The National Institute of Forensic Toxicology in Oslo receives blood and urine samples from all Norwegian drivers apprehended on suspicion of driving under the influence of alcohol or drugs. In this study, sex differences in use of alcohol and drugs among Norwegian drunken and drugged drivers were presented. In 1992 and 1993, the institute received samples from 11,970 and 5642 suspected drunken and drugged drivers respectively. Women were underrepresented among both suspected drunken (7.6%) and drugged (10.9%) drivers. There were not observed dramatic gender differences in frequency and finding of drugs. The most frequent drugs in addition to alcohol were tetrahydrocannabinol, benzodiazepines and amphetamine. The data suggest that benzodiazepines are found relatively more often in blood from female than from male drugged drivers. Lower proportion of women with blood ethanol concentration over the legal limit was observed.

Adolescent↗

PubMed1995

[Driving under the influence of benzodiazepines. Sale differences in the counties are reflected among drivers suspected of driving under the influence of a drug].

This study was based on all blood samples taken from drivers suspected of being influenced by alcohol and or drugs and sent to the National Institute of Forensic Toxicology in 1992. Benzodiazepines were among the most frequently detected drugs. The ratio between samples containing benzodiazepines and the total number of samples was compared with the sales of benzodiazepines in the different Norwegian provinces. In 95% of the benzodiazepine positive samples, either a combination with other drugs or a concentration significantly higher than usually found after ordinary therapeutic use was observed. These results indicated that the fraction of samples positive on benzodiazepines probably representing drug abuse or misuse correlated with the total prescription of benzodiazepines in the different Norwegian provinces.

Alcohol Drinking↗