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Biomedical subjects

S Sliwka

Publications and source records attributed to S Sliwka.

9 recordsLinked to original sources
PubMed1977

A fast method of estimating the elastance of the intracranial system.

The authors describe a fast method for estimating the elastance of the intracranial system in man. The method consists in constructing the so-called amplitude-pressure (Amp-P) curve which describes the relationship between the amplitude of pulse-related oscillations in cerebrospinal fluid pressure and the basic level of intracranial pressure. The Amp-P curve consists of two straight lines, and the point of intersection of these lines is thought to indicate the intracranial pressure level at which there occurs a qualitative change in the functioning of compensatory mechanisms of the intracranial system. The authors applied the method to examine the Amp-P curves of 10 patients without intracranial pathology and found that they provide a good description of the state and dynamics of the intracranial system. Preliminary data obtained in patients with intracranial pathology indicate that the method is a valuable tool in the diagnosis and treatment of neurosurgical patients.

Adult↗
PubMed1976

A method of estimating intracranial decompensation in man.

A new method of estimating intracranial decompensation in man is described. An on-line computer system is connected to an intracranial pressure (ICP) monitoring system to compute regression plots of mean ICP vs standard deviation; standard deviation is used as a measure of ICP instability. Two zones with distinctly different slopes are a characteristic feature of these plots. It is thought that the changes of slope signify intracranial decompensation.

Humans↗
PubMed1975

A computerized neurosurgical intensive care system.

A specialized neurosurgical data acquisition and processing system was developed and applied in practice to monitor some 60 patients after head injury or neurosurgical operations. At first the system allowed off-line operation, and the experiences thus gained made it possible to implement the system in its present form for real-time on-line patient monitoring. The algorithms prepared in our laboratory allow rapid and concise presentation of results and have proved their usefulness in clinical practice. The main parameters of interest in neurosurgery are intracranial pressure (ICP) and the volume of cerebrospinal fluid (CSF) drained from one of the lateral ventricles. Examples of statistical analysis of both these variables, and their presentation in the form of tables, diagrams and histograms are given.

Adolescent↗
PubMed1975

Computer-assisted analysis of intraventricular pressure after mannitol administration.

The effect of prolonged mannitol infusion upon intraventricular pressure was investigated with the aid of a specially-designed automatic digital recording system; the data recorded were processed off-line by a minicomputer. The character of the pressure curves is thought to result from interaction between the mannitol effect and the observed system's shifting equilibrium position, which is caused by other factors. The character of the pressure curves prior to mannitol infusion must be taken into consideration in estimating the actual effect of the drug; the authors suggest that in certain cases it might be possible to decrease further the rate of mannitol administration. The advantages of statistical approach to the evaluation of intracranial pressure variations are discussed.

Analysis of Variance↗
PubMedDate not supplied

[Statistical analysis of cerebrospinal fluid acid-base equilibrium and cerebrospinal fluid lactate concentration in cases of brain tumors, cerebrocranial injuries and meningoencephalitis].

A statistical analysis of CSF lactate concentration and CSF pH and PCO2 was performed. The values were obtained from 211 samples taken from 76 neurosurgical patients. The values of pH and pCO2 were classified in three groups corresponding to the following three ranges of lactate concentration: below 15 mg%, 15-30 mg%, over 30 mg%. The mean values and standard deviations were calculated: suitable tests: F, t (Student), C (Cochran and Cox) were used. It was established, that statistically significant changes of CSF acid-base balance were present at lactate levels over 30 mg%. Next, the patients with lactate concentrations over 30 mg% were analysed. They were divided into three groups according to etiology: inflammatory changes, injuries, tumours. It was shown, that the CSF acid-base balance in patients with brain tumours is less disturbed then in patients with inflammatory changes or brain injury.

Acid-Base Equilibrium↗
PubMedDate not supplied

[Statistical correlation between lactate concentration and acid-base equilibrium in cases of brain tumors, craniocerebral injuries and meningitis].

Statistical significance of correlations between lactate concentration and pH value as well as pCO2 in the cerebrospinal fluid was assessed in patients with brain tumours, craniocerebral injury and meningitis. After calculation of correlation indices it was found that with increasing lactate level the correlation between this level and the pH and pCO2 of the cerebrospinal fluid increases. Correlation coefficients were far from their maximal values (+1 or -1) which indicates absence of a direct cause-and-effect relationship between lactate concentration and both remaining values. The analysis of results in the group with lactate level exceeding 30 mg/100 ml demonstrated lowest correlation coefficients between these values in patients with meningoencephalitis.

Acid-Base Equilibrium↗