Uneven deposition of minimicrospheres in patients with obstructive lung disease.
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Biomedical subjects
Publications and source records attributed to S Solfanelli.
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A 22-year-old female patient with a swelling in the right forearm near the elbow underwent a 67Ga-citrate scan because of paraesthesia on the ulnar side of the right hand. The 67Ga total body scan showed intense focal uptake on the forearm in the same position as the swelling. At surgery a histological diagnosis of alveolar rhabdomyosarcoma was made. Five months later, a repeat 67Ga scan was normal. Eight months after the diagnosis, the patient complained of pain in the left lumbar region extending to the hypogastric area. A third 67Ga scan showed intense uptake near the spinal column which at surgery was found to be a metastasis of the primary tumor.
A technique based on inhalation of nebulized albumin minimicrospheres labeled with 99mTc (HAMM) was applied to visualize the redistribution of convective ventilation in the lung after a mucokinetic drug treatment. A randomized double-blind study comparing the effect of 7 days treatment with 800 mg daily oral sobrerol versus placebo in two groups of 10 patients each, affected by chronic bronchitis, was performed. Routine pulmonary function tests (PFT) and alveolar-arterial (Aa) gradients of oxygen and carbon dioxide were performed. Both PFT and Aa gradients did not show significant modification, but the inhomogeneity of HAMM deposition resulted significantly reduced after sobrerol treatment. By means of HAMM technique it was possible to show objectively the reduction of bronchial obstruction secondary to sobrerol treatment.
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Explore the source record for details and available documents.