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Biomedical subjects

S Spector

Publications and source records attributed to S Spector.

At least 217 records · Page 12Linked to original sources
PubMed1970

Morphine: radioimmunoassay.

The development of a radioimmunoassay for morphine is described. The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.

Animals↗
PubMed1969

Vascular smooth muscle reactivity in normotensive and hypertensive rats.

Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Thus, hypertension is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle.

Animals↗
PubMed1968

Yellow fever virus. I. Development and evaluation of a plaque neutralization test.

Heretofore, the most reliable way of measuring yellow fever virus antibody was to use the mouse neutralization (MN) test employing either suckling or weanling mice. Certain disadvantages (e.g., expense both of animals and of maintaining a mouse colony, allergic reactions of many laboratory workers, and the relatively long time, 21 days, before end points are reached) are inherent in any program with mice or other laboratory animal species and have discouraged the use of the MN test by many laboratories. A previously reported plaque neutralization (PN) test with primary chick embryo cell cultures could not be consistently reproduced by later investigators. We have developed a convenient and reproducible PN test employing the MA-104 embryonic rhesus monkey kidney cell culture and a single agar-overlay procedure. When compared with MN tests with newborn (1 to 3 days old) and weanling (16 to 20 g, 24 to 28 days old) mice inoculated by the intracranial route, the PN test was the most sensitive for measuring neutralizing antibody; it was also less variable, less costly, and it achieved results in the shortest period of time. End points could be determined in 5 to 6 days for the PN test as compared to 21 days for the MN test.

Agar↗