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S Sporny

Publications and source records attributed to S Sporny.

At least 19 recordsLinked to original sources
PubMed2003

Fine needle aspiration cytology in non-neoplastic non-toxic recurrent nodular goitre.

The aim of the study was to examine whether evaluation of anisokaryosis is helpful in the cytological diagnosis of focal lesions in non-toxic recurrent goitre (NRG) after thyroidectomy for non-malignant goitre. Karyometric analysis was performed in routine cytological smears obtained from 80 females: 40 with focal lesions in non-toxic primary goitre (NPG) and 40 with NRG (postoperative histopathological examination revealed nodular goitre in both groups in all cases). We found that the level of anisokaryosis was significantly (P<0.005) higher in NRG than in NPG. There were no significant differences between the two lesions, in cellular composition or thyroid follicular cell arrangement. Thus, isolated anisokaryosis, a feature of malignancy in patients without a prior thyroidectomy, has limited diagnostic value in recurrent goitre.

Adult↗
PubMed2001

[Liver tuberculosis].

The case of rare localization of extrapulmonary tuberculosis--isolated tuberculoma of the liver--was described. The tumor was found accidentally, during abdominal ultrasound for benign prostatic enlargement. Computed enhanced tomography didn't explain the character of the tumor, so percutaneous thin-needle biopsy was performed. Preliminary histological report suggested primary liver cancer. Patient was operated on, tumor was removed with the margin of the healthy liver tissue. Histological examination of the specimen revealed the nature of the tumor. Diagnosed liver tuberculoma is usually treated without surgery.

Aged↗
PubMed2001

[The role of fine needle biopsy in diagnosis of thyroid cancer].

The majority of changes in the structure and consistency of the thyroid gland is a clear indication for fine needle aspiration biopsy (FNAB). This does not mean, however, that cytological evaluation provides an unequivocal diagnostic confirmation for every pathological change found by palpation or by imaging technology. The main purpose of FNAB is to differentiate the type of examined pathological lesion (i.e. neoplastic or non-neoplastic) and to help in the selection of appropriate therapy. The diagnoses obtained by FNAB may be divided into five categories. FNAB plays the key role in the diagnostics of papillary and anaplastic thyroid carcinoma.

Biopsy, Needle↗
PubMed2001

[Differential criteria between papillary and follicular thyroid carcinoma--initial conclusions from a multicenter trial].

Histopathological diagnosis of thyroid cancer is difficult and requires much experience. Pathologists have to know many histopathological variants and be aware of the current diagnostic criteria. The aim of the study was to unify criteria applied all over the country and compare whether the accuracy of diagnosis has changed in the course of the last fifteen years. In a multicenter trial, 36 pathologists from 25 centers reevaluated 232 thyroid tumors operated between 1985-1998. The reference diagnosis was given on the basis of evaluation made by four experienced pathologists. The two-step analysis was performed. At first, the accuracy of the diagnosis of malignant neoplasm was evaluated. Then, the accuracy of the diagnosis of the cancer histotype was analyzed, with estimation of kappa coefficients and their asymptomatic standard error. Comparison of primary and reference diagnoses revealed statistically significant differences--in 17% of cases the primary diagnosis of cancer was not confirmed by experienced pathologists. Kappa coefficient for the diagnosis of cancer histotype was 0.53 + 0.06. On the contrary, the diagnoses made by the participants of the trial did not differ significantly from the reference ones. Kappa coefficient for the diagnosis of cancer histotype was significantly higher than for primary diagnoses with 0.63 +/- 0.10 (p < 0.001). The first results of the multicenter trial indicated that the most frequent diagnostic error made at primary diagnosis was the overdiagnosis of follicular thyroid carcinoma. Thus, a summary of strict criteria for papillary and follicular thyroid carcinoma is also given.

Adenocarcinoma, Follicular↗
PubMed2001

[Criteria for histopathologic diagnosis of thyroid cancer in a quick test of accuracy].

A quick test of accuracy of histopathological diagnosis of thyroid carcinoma was performed in May 2000 during the meeting of Polish thyroid cancer group (Committee for Epidemiology, Diagnosis and Treatment of Thyroid Carcinoma). 29 pathologists participated in the test and evaluated 8 cases of thyroid carcinoma and 14 benign thyroid lesions. All cases were chosen from the current material sent for pathologic evaluation to the Institute of Oncology in Gliwice due to diagnostic difficulties. In total, 591 diagnoses were made and were the subject of the presented analysis. They were compared with reference diagnosis in two aspects. First, the accuracy of the distinction between malignant and benign lesions was evaluated. 72.5% of diagnoses were concordant with the reference. The false diagnosis of cancer in a benign lesion was observed 133 times (22.5% of all diagnoses). A reverse error--a false exclusion of cancer--was seen in 29 diagnoses (4.9%). Chi 2 test revealed a statistically significant difference between the participants' diagnoses and reference ones (p < 0.0001). Overdiagnosis of cancer was the most frequent at the diagnosis of follicular or oxyphilic cancer. With reference to the diagnosis of cancer histotype, concordant diagnoses were seen in 40-47% of cases with the lowest accuracy of the diagnosis of oxyphilic (40% of correct diagnoses) and follicular (50%) cancer. The causes of false diagnoses may be divided in two groups: sample-related causes (sampling of surgical specimens, lack of standard description, insufficient number of samples, poor quality of staining) and diagnostic errors: non-compliance with diagnostic criteria and inappropriate setting of diagnoses, which require immunohistochemical confirmation.

Adenoma↗
PubMed2000

Circadian variations in hepatotoxicity of carbon tetrachloride in mice.

Male mice of Balb/C strain were administered i.p. carbon tetrachloride, in single doses of 35 and 145 mg/kg, given at variable time of the day. The activity of alanine aminotransferase (ALAT) in serum, and the hepatic level of malondialdehyde (MDA) as well as reduced glutathione (GSH) were adopted as indicators of toxicity. In selected groups, liver histopathology was carried out. The experiment was performed in two series differing in the dynamics of observations. A differentiation of the intensity of toxic effects was found dependent on the time of the day at which animals were administered the xenobiotic. This was especially evident for a lower dose: given in the morning it produced no effects, whereas given in the evening it resulted in distinct elevation of toxicity indicators. Additionally, the correlation was checked between the histopathological evaluation (semiquantitative expression) and serum ALAT activity. A high correlation (r = 0.98) allows for basing the evaluation of liver necrosis on the ALAT activity alone.

Analysis of Variance↗
PubMed1997

Usefulness of computer-aided karyometric examination in preoperative differentiation of Hürthle cell lesions.

We have previously reported that there is a significant difference in the mean size of thyrocyte nuclei among patients with nodular goiter, follicular adenoma, and follicular carcinoma. In the present study, we have examined karyometric parameters of Hürthle cells in smears collected from 41 patients with Hürthle cells adenomas, Hürthle cells carcinomas, nodular goiter, and lymphocytic thyroiditis. The karyometric evaluation was performed with the image analysis computer system-Karyometry Manager 1.2. We measured the mean volume, the mean intersection area, and the mean perimeter of 100 nuclei in each routine smear. We found that the sizes of Hürthle cell nuclei could be arranged in the ascending order from the nodular goiter, through lymphocytic thyroiditis to Hürthle cell neoplasms, but those differences did not reach a border of statistical significance.

Adenoma, Oxyphilic↗
PubMed1997

Karyometric analysis in the cytologic diagnosis of thyroid lesions.

OBJECTIVE: To assess the possible role of karyometry in improving the diagnostic value of fine needle aspiration biopsy (FNAB) of the thyroid. STUDY DESIGN: Thyrocyte nuclei were evaluated in routine slides obtained from 229 patients. The cytologic specimens were divided into seven groups according to the results of corresponding postoperative histopathologic examinations. Karyometric measurements comprised assessment of nuclear volume intersection area and perimeter as well as level of anisokaryosis, evaluated as standard deviations of those parameters in single slides. The karyometric evaluation was performed with a computerized image analysis system. RESULTS: The size of thyrocyte nuclei increased from nontoxic nodular goiters through follicular adenomas, toxic nodular goiters treated with antithyroid drugs, lymphocytic thyroiditis, papillary and follicular carcinomas to anaplastic carcinomas. The observed differences between those groups were statistically significant, but there was marked overlapping. Our data indicate also that the age and sex of the patient influence the cytologic picture of nodular goiter. The evaluation of anisokaryosis increases the usefulness of karyometry in differentiating malignant neoplasms from benign lesions. CONCLUSION: Karyometric analysis increases the probability of a correct diagnosis with FNAB examination.

Adenocarcinoma, Follicular↗
PubMed1995

[Carcinoma on the base of the ovarian struma].

A rare case of carcinoma developed in struma ovary in 55 year-old woman. During surgical intervention, the carcinoma infiltration in ovary stroma was diagnosed. The metastases were not stated. In the immunohistochemical assay, thyroglobulin and cytokeratin in neoplastic cells were displayed. Clinical examination did not show any signs of hyperthyreosis.

Female↗
PubMed1993

The usefulness of computer-aided karyometric examination in preoperative differentiation of follicular neoplasms of the thyroid gland.

Fine-needle aspiration biopsy (FNAB) is the most important procedure in preoperative diagnosis of thyroid neoplasms. However, routine cytological examination is insufficient for differentiation between follicular adenoma and follicular carcinoma. Therefore, we decided to assess the usefulness of karyometric analysis in the examination of aspirates from these neoplasms. Morphometric analysis was performed with the use of the computer system for karyometric measurements--"Karyometry Manager" ver. 1.2. We examined cytological smears derived from 26 patients. In 10 of them a nodular goitre was diagnosed in both cytological and histopathological examinations. In the other 16 patients, "follicular neoplasms" were found in cytological examination. These proved to be follicular adenomas (8 cases) and follicular carcinomas (8 cases) on histopathological examination. The following morphometric parameters were measured in 100 nuclei per smear: volume, intersection area, perimeter, convexity coefficient and shape coefficient. We found that: 1) the mean volume and the mean intersection area of thyrocyte nuclei from follicular carcinomas were significantly (p < 0.001) greater than those of nuclei from adenomas or nodular goitres; 2) the mean perimeter of thyrocyte nuclei from follicular carcinomas was significantly greater than the mean perimeter of thyrocyte nuclei from follicular adenomas (p < 0.025) and nodular goitres (p < 0.001); 3) the mean nuclear area of thyrocytes from follicular adenomas was significantly greater than that of thyrocytes from nodular goitres (p < 0.05). Our results show that karyometric analysis can be useful in cytological differentiation of follicular neoplasms.

Adenocarcinoma, Follicular↗
PubMed1993

Effects of the pineal gland on the growth processes of Guerin epithelioma in male Wistar rats.

The effects of pinealectomy (PX) and melatonin (Mel) administration on the growth processes of Guerin epithelioma, a malignant tumour derived from spontaneous cancer in Wistar rat uterus, was investigated in five groups of male rats. The mean life span of the rats bearing Guerin tumours (GT) and subjected to PX was shorter than in animals with an intact pineal gland. Mel did not affect the lifespan in rats with intact pineals or in those subjected to PX. Mel decreased the mitotic activity of GT cells in rats with and without the pineal gland. Pathomorphological examination revealed high malignancy of the primary tumour but no metastases. The results confirmed the important role of the pineal gland in 'oncostasis'.

Animals↗
PubMed1992

Effects of 3-methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen.

This report presents a set of investigations on the hepatotoxic action of acetaminophen (AA). Male mice of Balb C strain were given [3H]acetaminophen in doses of 100, 300 and 600 mg kg-1 with or without pretreatment with 3-methylcholanthrene (3MCh) or diethyl maleate (DEM). The results of this study show that AA administered in moderate doses brings about necrotic changes due to adduct formation with macromolecules. Adduct formation was inversely correlated with the level of glutathione. Both modifiers enhanced hepatic necrosis and lethality. Diethyl maleate exerted these effects without enhancing covalent binding to macromolecules, while 3MCh increased both adduct formation and lipid peroxidation.

Acetaminophen↗
PubMed1992

Intestinal absorption of inorganic mercury in rat.

203Hg-Mercuric chloride was administered intragastrically to female rats. The absorption rate evaluated for a broad range of doses was found constant for low and medium range, and higher for high doses. Mercury was determined in internal organs and intestines. The time-course of intestinal mercury indicated that a deposit formed initially in the mucosa was further absorbed into the circulation. No indication was found of a protection mechanism based on exfoliation of the mucosal deposits of metal.

Animals↗
PubMed1992

[Comparative analysis of fine needle aspiration biopsy results performed in the laboratory of thyroid diseases, University School of Medicine in Lodz in 1985-91 with results of postoperative histopathologic examinations].

From 1985 to 1991 there were 5889 fine-needle aspiration biopsies of thyroid performed in our laboratory. 703 cytological diagnoses based on biopsy specimens taken from 679 patients, were compared with the results of postoperative histopathological examinations. There were 14% non-diagnostic biopsies. The statistical analysis was performed considering difficulties in differentiation between follicular adenomas and follicular carcinomas. Difficulties in evaluation of biopsies of cystic lesions were also considered. The results of cytological and histopathological examinations were agreeing with one another in 88% cases. In regard to diagnosis of malignant neoplasms, the sensitivity of the cytological investigation was equal to 63% and the specificity equaled to 90%. While considering detection of papillary carcinomas, the sensitivity was equal to 67%. Our results are in a compliance with the view, that the fine-needle aspiration biopsy is a useful method in a preoperative diagnosis of thyroid lesions.

Biopsy, Needle↗