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Biomedical subjects

S Springer

Publications and source records attributed to S Springer.

At least 37 records · Page 2Linked to original sources

[From infant nurse to "baby-friendly hospital"--promotion of breast feeding in the University Women's Hospital in Leipzig].

The attitude of medical professionals towards natural infant feeding is decisive in the support of mothers who want to breastfeed. The atmosphere in a "Baby-Friendly Hospital" is determined by the creation of conditions for breastfeeding on demand and for early, undisturbed mother-child contact. At the University Women's Hospital in Leipzig the development of good breastfeeding management was supported by the employment of a "breastfeeding nurse" and enhanced by continuing education for physicians, nurses and midwives in lactation and breastfeeding. In this way comprehensive, uniform information as well as practical guidance important for breastfeeding success were ensured for pregnant and young mothers.

Adult↗

[Vaccination of pigeons against Salmonella infections].

The efficiency of the live vaccine Zoosal T with a double marker mutant of Salmonella Typhimurium was tested on conditioned pigeons. For challenge infection we used a pigeon specific variation copenhagen strain in a defined state of virulence. The reduction of mortality and the persistence of Salmonella in organs were evaluated. An oral booster enhances the protection due to vaccination.

Animals↗

Promoting use of a preferred histamine H2-receptor antagonist in managed care organizations.

A program to promote generic cimetidine as the preferred histamine H2-receptor antagonist (HRA) in the managed care organizations (MCOs) served by a pharmacy benefit management company is described. A pharmacy benefit management company conducted a literature review to substantiate the therapeutic equivalence of the HRAs and to set conservative criteria for identifying candidates for conversion to oral cimetidine therapy. During the third quarter of 1994, the prescriber for each patient identified was sent a document listing the patient's current HRA therapy, the date of his or her last prescription refill, and the name and telephone number of the dispensing pharmacy. A letter summarized the literature; outlined the criteria used to identify candidate patients; gave the current indications, dosages, and average wholesale prices of the HRAs; and asked the prescriber to switch the patient to generic cimetidine. HRA use in an MCO that participated in the program was compared with HRA use in a nonparticipating MCO for the second quarter of 1994 (the baseline period), the fourth quarter of 1994, and the first quarter of 1995. The nonparticipating MCO showed no change between baseline and 1995 in the proportion of HRA prescriptions accounted for by brand-name and generic cimetidine combined (14% for each period). The average acquisition cost per HRA prescription remained about $75 for each study quarter. In the participating MCO, the proportion of HRA prescriptions accounted for by brand-name plus generic cimetidine increased from 18% at baseline to 39% in the first quarter of 1995. The average acquisition cost per HRA prescription fell from $71 at baseline to $65 in the first quarter of 1995. A program to shift the use of brand-name HRAs to generic cimetidine in MCOs successfully altered prescribing patterns and reduced expenditures for these agents.

Cimetidine↗

[Periodic breathing with periodic oxygen variation in infancy].

Oxycardiorespirographies, recording arterial oxygen saturation (SaO2), breathing movements, heart rate and ECG with a mean recording time of 22.3 hours, were performed on 85 preterm (mean postconceptional age: 38 weeks) and 81 term infants (mean postconceptional age 42.4 weeks). 83% of the preterm infants showed periodic breathing (PB), in 97% of them this was accompanied by periodic variations of arterial oxygen saturation (PVO). Periodic breathing occurred in 61% of the term infants, 84% of them showed PVO during periodic breathing. The mean variation of oxygen saturation was between 92.8 and 96.8% (+/- 1.7) for preterm and between 92.9 and 96.0% (+/- 2.2) for term infants. In some infants the peak to peak amplitude of the SaO2 cycles was up to 22%, sometimes a further fall of SaO2 occurred. There was a strong correlation of the PVO both at the beginning and end of the episode as well as with the PB-cycle periodicity itself. The fall of the oxygen saturation occurred 3.1 to 7.8 s after the beginning of the first apnea of an episode of periodic breathing, the minimum SaO2 was reached approximately 4.2 to 8.6 s later. This periodic rapid fall of SaO2 from a high oxygenation level cannot be explained by the apneas of a rather short duration during periodic breathing. It is discussed that PVO during periodic breathing may be caused by an ideopathic right to left shunting across fetal circulation pathways which occurs intermittently and periodically. This mechanism could-via patterns of reaction exhibited during the fetal and neonatal time period-lead to acute hypoxemia, as found in apparently life threatening events (ALTE) and as postulated in sudden infant death (SID).

Gestational Age↗

Gender differences in cerebral perfusion in cocaine abuse: technetium-99m-HMPAO SPECT study of drug-abusing women.

UNLABELLED: Cocaine abuse continues to be a major public health concern, with a variety of medical and neurologic sequelae. Previous studies have demonstrated abnormalities in cerebral perfusion in chronic cocaine abusers and after acute administration of cocaine. Although women are becoming increasingly represented among drug abusers, few studies have included women. To the authors' knowledge, none has compared cerebral perfusion in asymptomatic women with that in men. METHODS: The cerebral perfusion of 13 cocaine-dependent women, 4 of whom were also heroin dependent, was studied with 99mTc hexamethylpropyleneamine oxime (HMPAO) SPECT. These women were compared with 13 cocaine-dependent men and 26 healthy control subjects. Structural brain lesions and neurologic abnormalities were excluded by MRI and neurologic evaluation. Perfusion studies were interpreted in a standardized fashion by reviewers blinded to clinical information. RESULTS: It was found that cocaine-dependent women were much less likely to have abnormal study findings than cocaine-dependent men (p = 0.003) and were indistinguishable from normal women (p = 1.0). However, the results in both women and men who concurrently used heroin plus cocaine were all abnormal. Perfusion abnormalities tended to be located in anterior brain structures, such as the frontal and temporal cortex and the basal ganglia. CONCLUSION: These data suggest that cocaine-dependent women have fewer abnormalities in cerebral perfusion than cocaine-dependent men, but that concurrent abuse of heroin and cocaine is associated with more perfusion abnormalities in both sexes.

Adult↗

Disordered communication and grieving in deaf member families.

When a deaf child is born to hearing parents, a grieving process is initiated in the parents. Unresolved grieving over their child's deafness often makes it difficult for hearing parents to accept the importance of signing, thus increasing the child's problems--a further source of grief for these parents. Clinical illustrations are provided of (1) the reciprocal relationship between disruption of the mourning process and disturbance of communication between family members, and (2) the transmission of the dysfunctional relationship between hearing parents and deaf children to the subsequent relationship between the deaf children, when they reach adulthood, and their hearing children.

Adolescent↗

[Diagnosis, therapy and prevention of necrotizing enterocolitis in newborn infants].

The necrotizing enterocolitis is a severe and frequently fulminant disease with a considerable mortality. The main event is the enteral septicemia. Only prompt diagnostics and adequate therapy permit the survival of the newborns. The most important aspects of signs and symptoms, diagnostics and therapy as well as course of disease and prophylaxis are delineated, whereas the problems of pathogenesis are excluded.

Combined Modality Therapy↗

[Consequences of the composition of human milk for the nutrition of low-birth-weight neonates. III. Sodium and potassium].

The concentrations of sodium and potassium were studied in the 24 hour pooled human milk of 37 mothers delivered preterm (PTM) and of 19 mothers delivered at term (TM) from the second to the eighth postnatal day and in addition in the PTM during the third week of lactation. During the 4th week of life the sodium balance was estimated in 31 very low birth weight infants fed a human milk formula enriched with NaCl (n = 11) or NaH2PO4 (n = 11) and in 9 infants fed the same formula without supplementary sodium. The concentrations of sodium decrease significantly during the first week of lactation. The values are significantly higher in PTM than in TM during the first 3 days but decrease in both milks to values between 1 and 2 mmol/100 ml. The concentrations of potassium increase up to the 4th day of lactation and fall to approximately 1.5 mmol/100 ml at the end of the first week of lactation. There are no differences between PTM and TM. In all three balance groups the sodium balance are positive. But only in the infants fed a sodium-supplemented human milk formula the weight gain was adequate according to the protein and caloric intakes. No signs of a pathological sodium retention could be observed during the balance period. The data suggest that a sodium intake of more than 2.5 mmol/kg/day is necessary for optimal growth. Thus, the phosphorus supplementation should be done generally as 1 mmol NaH2PO4/100 ml human milk in very low birth weight infants.

Energy Intake↗

[Development and organization of breast milk collection centers in East Germany].

Human milk banking has a longstanding tradition in the GDR. We report on the main data of a survey carried out in 1987, actualized in 1989. Whereas human milk banking was widespread during the 1950s, it reached it's lowest level in 1972. In 1988 the amount of collected milk was nearly 200,000 litres (60 milk banks). Thus, the supply met the demand approximately. The development of the human milk banks is characterized by an increase of the number of milk banks (mostly the banks are affiliated to a children's hospital) and the collecting capacity. Half of the milk banks carries out the collection on a daily basis. This makes it possible to provide fresh milk with it's clear-cut advantages, especially in immunological respect. Otherwise the milk is stored after boiling, freezing or pasteurization. The feeding of very low birth weight newborns with fresh human milk is steadily increasing with corresponding consequences for the quality control of donated milk and the management of milk banks.

Germany, East↗

[Consequences of the composition of breast milk for the nutrition of underweight newborn infants. II. Lipids and lactose].

The concentrations of fat, lactose and protein were measured in the 24 hour pooled breast milk of 37 mothers delivering preterm (PTM) and of 19 mothers delivering term (TM) from the second to the eighth postnatal day and in addition in the PTM from the third week of lactation. During the 4th week of life the nitrogen retention, the fat absorption rate as well as the energy balance were estimated in 21 very low birth weight infants appropriate for gestational age fed either native PTM (n = 11) or by heating procedures sterilized PTM (n = 10). The concentrations of fat and lactose increase within in the first week of lactation. The concentrations of fat are higher in the PTM during the first 3 days of lactation which results in a higher energy density of PTM during the first days of lactation. At the end of the first week of lactation there are no differences in the energy density between PTM and TM. The fat absorption rate was significantly lower in the infants fed sterilized PTM than in the infants fed native PTM (70.5 +/- 8.4 vs 86.3 +/- 7.4 p.c.). Thus, an energy intake of (70.5 to 8.4 vs 86.3 +/- 7.4 p.c.). Thus, an energy intake of 120-130 kcal/kg.d or an energy absorption of more than 100 kcal/kg.d; respectively, is possible by feeding native PTM as well as TM when feeding volumes of more than 180 ml/kg.d are tolerated. When sterilized breast milk is used or the feeding volume is below 160 ml/kg.d an energy supplementation of the milk is necessary.(ABSTRACT TRUNCATED AT 250 WORDS)

Breast Feeding↗

The use of somatosensory evoked potentials for detection of neuropraxia during shoulder arthroscopy.

With the increase in the use of shoulder arthroscopy in the past decade, there has been an increased awareness of complications. Reports of the occurrence of transient neuropraxia indicate an incidence of 10%-30%. The recording of somatosensory evoked potentials (SEP) for the study and functional monitoring of the sensory pathway is well accepted as a reproducible method of monitoring peripheral nerve and spinal cord function during surgery. SEPs were recorded during shoulder arthroscopy in 20 patients to monitor the musculocutaneous nerve, ulnar nerve, and either the median or radial nerve. In all 20 cases, abnormal SEPs of the musculocutaneous nerve were demonstrated. In 16 cases, this was produced upon initial joint distention, and in 15 cases, by traction; in 11, by longitudinal traction of greater than or equal to 12 lb, and in six by perpendicular traction of greater than or equal to 7 lb. In 10 patients, there were varying combinations of median, ulnar, and radial nerve involvement. There were two cases of clinical neuropraxia in this series. One resolved in 24 h and one in 48 h. The conclusion is that there is a real potential for neurologic damage during shoulder arthroscopy and that the musculocutaneous nerve is the most vulnerable. Factors responsible include joint distention, excessive traction, and extravasation of fluid. The use of SEPs provides a reliable means for monitoring the neurologic status of the extremity during shoulder arthroscopy.

Adult↗

Strategic family therapy interventions with deaf member families.

A deviance based model of deafness is compared with one based on ethnicity. The function of inadequate communication in deaf member families is explored. Techniques of intervention are examined with a focus on three strategic interventions namely: 1) circular interviewing; 2) positive connotation; and, 3) use of rituals. Case histories are provided.

Adolescent↗