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Biomedical subjects

S Srimuang

Publications and source records attributed to S Srimuang.

29 records · Page 2Linked to original sources
PubMed1988

Cryptococcal antigen survey among racing pigeon workers and patients with cryptococcosis, pythiosis, histoplasmosis and penicilliosis.

The cryptococcal antigen latex agglutination system (CALAS) test is simple, sensitive and specific. A total of 129 serum samples, 29 cerebrospinal fluids (CSF) and one ascitic fluid from 143 subjects were tested in the study. Cryptococcal antigenaemia was present in all CSF specimens tested from patients with culture-proven cryptococcal meningitis and cryptococcaemia, and in 91% of tested serum from the same group of patients with cryptococcal meningitis and cryptococcaemia. The occurrence of false positive results among sera obtained from patients with phycomycosis (zygomycosis) due to Mucor spp., Conidiobolus coronata and Pythium spp., and from patients with Penicillium marneffei infections, was not observed. A random survey of 101 high risk subjects, who had fed pigeons for two months up to 40 years, for cryptococcal antigenaemia was also carried out and 4% were positive for cryptococcal antigenaemia. Of 14 Cryptococcus neoformans strains obtained from CSF cultures of patients with cryptococcal meningitis, and with cryptococcaemia, during 1977-1986, ten strains were serotype A and D, and four strains were serotype B and C.

Adolescent↗
PubMed1988

In vitro and clinical evaluation of ofloxacin in urinary tract infection and enteric fever.

During 1984 to 1988, 35 patients with urinary tract infection (UTI) and 37 patients with enteric fever were treated successfully with 400 mg ofloxacin twice a day for 7 to 10 days. Clinical cure or improvement was observed in 31 of the 35 patients with UTI; 32 patients were bacteriologically assessed and eradication was achieved in all of them. Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyphi A subsequently died, due to his underlying disorder. The MIC90 of the Enterobacteriaceae including Salmonella was less than 0.12 micrograms/ml. Interestingly, beta-lactamase-producing strains of Salmonella and other Enterobacteriaceae in the present study were 28% and 29%, respectively. Ofloxacin therefore offers an effective b.i.d. dosage schedule for enteric fever and UTI due to beta-lactamase-producing bacteria.

Adolescent↗
PubMed1987

Efficacy of acyclovir combined with immunopotentiating agents in the treatment of varicella-zoster.

In-vitro and in-vivo evaluation of cellular immune reactions (T-cell subset, E-rosette formation, 2,4-dinitrochlorobenzene, were made in patients with varicella-zoster infection (VZ) and with other intracellular infections. The data demonstrated depressed cellular immunity including a decrease in the number of T-helper cells and a fall in the T-helper/T-suppressor lymphocyte subset ratio to less than 0.7. Three groups of patients with VZ infections were randomly assigned to three regimens: nine patients were given acyclovir alone for five days; ten patients received acyclovir for five days and isoprinosine for ten days; and twelve patients acyclovir for five days and levamisole twice weekly for three weeks. In patients with VZ infections treated with acyclovir and either levamisole or isoprinosine cellular immunity improved faster, while VZ infections in those treated with levamisole healed more rapidly. One patient treated with acyclovir alone had recurrent VZ infection and required a further course of therapy.

Acyclovir↗
PubMed1986

Ofloxacin, a new quinolone in the treatment of genitourinary and enteric infections.

During 1984 to 1986, 121 patients with gonorrhoea were treated with ofloxacin. This report is to summarize the results of our trial in patients treated with three different dose regimens of ofloxacin: A) a single 800 mg dose of ofloxacin (32 patients); B) a single 400 mg dose of ofloxacin (55 patients) or C) a twice a day dose of 600 mg ofloxacin (34 patients). In addition, 19 patients with urinary tract infection and eight patients with enteric fever were treated with 400 mg ofloxacin twice a day for seven to ten days. Out of 121 patients with gonococcal urethritis, only 107 patients were evaluable. Cure was obtained in 96.5%; 93.2% and 94.5% of the patients in groups A, B and C respectively. 16 out of 17 patients with urinary tract infection achieved clinical cure or improvement. The 16 patients were bacteriologically accessible; pathogens were eradicated in all of them. Ofloxacin was also effective in the treatment of enteric fever, in which eradication was achieved in all seven patients. 28% of Neisseria gonorrhoea and 29% of Salmonella spp. isolated in our community were beta-lactamase-positive.

Adolescent↗
PubMed1985

Use of temocillin in typhoid fever, hepatobiliary disease and other infections.

During 1980-1984, 51 patients with enteric fever (typhoid/paratyphoid fever and salmonellosis) biliary tract sepsis, and other Gram-negative infections were treated with temocillin at 3 medical centres in Bangkok, Thailand. This article summarises the results in the 42 evaluable patients (14 males, 28 females); 10 patients with enteric fever, 2 patients with salmonellosis; 12 patients with biliary tract sepsis, and 18 patients with other Gram-negative infections. Overall, 86% of the patients were clinically cured or improved. Bacteriological eradication or marked reduction in the number of organisms was achieved in 95% of the patients. In 10 cases of enteric fever and 2 cases of salmonellosis all bacterial pathogens were eradicated, but 1 case of Salmonella paratyphi infection failed clinically. Eleven of 12 biliary tract infections were clinically cured or improved, and organisms were eliminated from all 10 bacteriologically assessable patients. The majority of patients received 1 to 2g of temocillin given by intravenous infusion twice daily for 5 to 14 days. Temocillin was well tolerated by all patients.

Adult↗
PubMed1985

A case comparison of acquired immune deficiency syndrome (AIDS) in homosexual males with spindle-endothelial cell abnormalities and with recrudescent melioidosis.

The AIDS syndrome includes cases of biopsy-proven Kaposi's sarcoma in persons under 60 years of age, or biopsy- or culture-proven Pneumocystis carinii pneumonia, or either of the life-threatening opportunistic infections in young previously healthy persons with no underlying cause of immunodeficiency (Center for Disease Control criteria). Here we described the first case of AIDS with early Kaposi's sarcoma-like lesions in homosexual male drug addict and have compared the clinical and laboratory findings with those of another homosexual male having recrudescent melioidosis due to Pseudomonas pseudomallei.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Cellular immunity (T-cell subset using monoclonal antibody) in tuberculosis, melioidosis, pasteurellosis, penicilliosis; and role of levamisole and isoprinosine.

In vitro and in vivo evaluation of cellular immunity (T-cell subset--using monoclonal antibody--immunofluorescent staining technique; E-rosette formation to 2.4-Dinitrochlorobenzene reaction) were made in tuberculosis, melioidosis, pasteurellosis and penicilliosis. The data demonstrate depressed cellular immunity especially a significant decrease in numbers of T-helper cells and T-helper/T-suppressor subset ratio fell to less than 1.0. Of greater importance, in tuberculous patients and patients with melioidosis treated with levamisole, 150 mg/day, twice a week, along with a specific antitubercular or antimicrobial agent for appropriate duration, improved faster both clinically, microbiologically and in cellular immunity.

Adult↗
PubMedDate not supplied

The combination of pivmecillinam and pivampicillin in the treatment of enteric fever.

Thirty-nine patients with acute enteric fever received the fixed-dose oral combination of pivmecillinam/pivampicillin. Thirty-seven (95%) subjects responded satisfactorily. No relapses or persistent faecal excretion of salmonellae were seen in the 29 patients followed up for 2 to 19 weeks. The treatment was well tolerated, no side-effects being recorded. In vitro studies revealed a synergistic interaction between mecillinam and ampicillin against isolates of Salmonella paratyphi A.

Adolescent↗