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Biomedical subjects

S Staub

Publications and source records attributed to S Staub.

At least 19 recordsLinked to original sources
PubMed2005

[Round and anatomical mammary implants. Respective advantages and disadvantages].

The authors report of their experience of mammary augmentation with anatomical implants from 10 years ago. The important proportion of rotation of those anatomical implants obliged them to stop the clinical serie. Sylvain Staub return to a "revisited" classical technique with round implants, smooth in a majority of cases and placed them most of the time in a retromuscular pocket. Eric Auclair, ceduced by the concept of anatomical implants, decided to continue in this direction with a personal concept of anti rotation system. He shows a strategie of mammary augmentation that favorise the premuscular position and define the respective place of round and anatomical implants.

Breast↗
PubMed1995

Estradiol stimulates c-myc proto-oncogene expression in normal human breast epithelial cells in culture.

The proto-oncogene c-myc is involved in the stimulation of cell proliferation, and its expression is known to be stimulated by estradiol (E2) in human breast cancer cell lines and various non-cancerous E2-dependent tissues. However, little information is currently available concerning its expression and regulation in normal human breast tissue. We therefore studied c-myc expression and hormone modulation in normal human breast epithelial (HBE) cells in culture, routinely obtained in our laboratory and which remain hormone-dependent. On these normal HBE cells, E2 induced a biphasic increase in c-myc mRNA level, with a first peak as early as 30 min, and a secondary increase after 2 h of treatment; this stimulation was dose-dependent, with an optimal concentration of 10 nM E2. Its primary action is probably at the transcriptional level since the half-life of c-myc mRNA measured in the presence of actinomycin D (12 +/- 3 min) was not modified by E2 treatment. In addition, E2 stimulation of c-myc mRNA does not require protein synthesis since it was not suppressed by cycloheximide treatment. Western blot studies of c-myc protein in HBE cells revealed the same biphasic pattern of stimulation, with a first peak after 60 min and a second one after 2 h of E2 treatment. In conclusion, the c-myc proto-oncogene is expressed in normal HBE cells, as in breast cancer cells. Moreover, E2 stimulates c-myc expression which, therefore, may partly mediate the growth-promoting effect of E2.

Breast↗
PubMed1995

[Lateral fat in upper blepharoplasty].

"The eyebrow fat pad" was described by Charpy in 1909 without raising the interest of plastic surgeons. Over the last 5 years, we have removed this fat in 20% of our cases of superior blepharoplasty. This technique allows a reduction of the thickness of the upper eyelid to a lesser degree than that obtained by bone remodelling. We present the operating technique illustrated by clinical examples.

Esthetics↗
PubMed1991

[Evaluation of results of a series of 58 breast reconstruction after cancer].

The evaluation of 58 breast reconstructions operated in Boucicaut Hospital demonstrated positive result. The authors review the techniques used for contralateral breast symmetrization. The policy generally adapted has been to perform two sequential operations: 1st step: implantation of a prefilled prosthesis and contralateral breast symmetrization; 2d step: reconstruction of areolo-nipple complex and refinement of contralateral breast. Radiotherapy seems to be a problem in reconstruction. A 12% recurrence rate has been quoted in this group. Tram flap has been exceptionaly used by our team, as we tend to prefer the latissimus dorsi myocutaneous flap. Very few expanders have been implanted.

Breast Neoplasms↗
PubMed1990

[Objective evaluation of the results of interventions for breast hypertrophy].

It would appear to be impossible to compare completely different techniques of mammaplasty performed in very different clinical situations. However, we thought it would be useful to approach the result of mammaplasties from a more "orthopaedic" point of view. Such an approach distinguishes populations of patients with different results and in whom the postoperative assessment must take into account the result obtained, the residual scars and the final breast shape. A formula has been developed after multiple attempts: [formula: see text] This formula expresses positive factors: the quantity of glandular tissue removed (in grams), the final appearance of the scars, the appearance of the overall shape of the two reconstructed breasts and the reappearance of ptosis measured from the edges of the breast below the inframammary sulcus (in the erect position). In this way, it is possible to express these positive factors by the multiplying the scores attributed to each of the factors. For example, a resection of 150 g will be scored as 1.5 and a resection of 1,200 g will be scored as 12, i.e. the weight in grams is simply divided by 100 to give the score for weight. The scar will be scored according to an individual scale of 1 to 5. The shape will also be scored according to an individual scale of 1 to 5. The division factors include the length of the inframammary scar (segment 3); this inframammary vertical line will be included directly in the calculation. In contrast, the length of the horizontal inframammary scar will be divided by 10.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Juvenile mammary hypertrophy. Early surgical treatment].

The elastic and retractile nature of young skin allows glandular reductions to be performed without skin excision for the treatment of mammary hypertrophy in very young girls. These reductions in volume prevent secondary ptosis and stretch marks and are performed via an isolated inframammary incision. The devascularisation induced blocks glandular growth and no recurrence of hypertrophy has been observed in our series of 34 cases with a mean follow-up of 16 months.

Adolescent↗
PubMed1986

Correction of mammary ptosis with glandular atrophy.

Excess skin and insufficient gland are two problems posed by the correction of the small ptotic breast. A single-stage operation can resolve these problems. Our technique used for 20 patients proved satisfactory with a low rate of complications.

Adult↗
PubMed1986

Treatment of cervical burn contracture with two fasciocutaneous flaps.

A case of cervical obliteration following a chemical burn is reconstructed with 2 fasciocutaneous flaps transposed from the upper chest. The technique is rapid and yields good quality long-term results. It compares favorably with skin grafting and distant flap repair in ease of execution as well as aesthetic and functional results. The donor defect may be problematic in certain cases.

Adult↗