Hepato-splenic mycotic abscesses in patients with acute leukemia.
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Biomedical subjects
Publications and source records attributed to S Storti.
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A case of acute monocytic leukemia with an apparent isolated skin relapse is reported. The cutaneous involvement was associated with a morphological bone marrow remission but a cytogenetic relapse was present. Regression of the skin lesions was obtained with a protocol including daunoblastine, aracytin and thioguanine, but the patient relapsed and died a few months later without achieving another remission. The relation between cutaneous and medullary disease is discussed.
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A patient with an inferior vena cava thrombosis in nephrotic syndrome was treated with heparin, AT-III concentrates and urokinase. After a few days on treatment he showed a complete resolution of the thrombosis. We suggest that this therapeutic combination may be a good approach to the treatment of thrombosis in nephrotic syndrome.
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Sixteen elderly patients affected by acute non lymphoblastic leukaemia (ANLL) with a preexisting severe internal disease were treated with a low systemic toxicity drugs combination: OAP (Vincristine, Cytarabine and Prednisone). Complete remission was achieved in 5 patients (31%) after 2 OAP courses. The mean duration of remission was 18 weeks. Six patients were resistant to the therapy. Six patients died during the treatment: 5 in induction phase and 1 in consolidation phase. Even though the duration of remission was short we retain that OAP combination may be still considered a good therapeutical approach in elderly ANLL patients with associated severe internal disease.
The recent studies, related in medical literature, indicate a reduced activity of fibrinolysis in patients with low back-pain caused by multiple factors (lumbar disc disease, post-laminectomy, post myelography) and suggest a new pathogenetic hypothesis of this disease and new therapeutic implications. The authors conducted a research based on the study of fibrinolysis in patients affected by post-surgical lumbar adhesive syndrome, with the aim of finding, eventually, a relationship between reduced fibrinolytic activity and clinical symptoms. The results are referred and discussed.
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The authors describe two cases of acute nonlymphoblastic leukemia, FAB subtype M4, who developed a lung cancer while in complete remission of the leukemia. The possible interrelations between the two diseases are discussed.
In this paper we describe a patient with acute lymphoblastic leukemia followed after 4 years by a Ph1-positive chronic myelogenous leukemia. The possible relationship between these two diseases is discussed.
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Seventeen cases of acute leukemia or lymphoma which required emergency surgery for acute abdominal pain, are reported. It is concluded that surgery in these patients should be performed whenever indicated because the mortality rate of medical treatment is around 100%.
The case of a patient with myelofibrosis who developed polycythaemia vera after corticosteroid therapy, splenectomy and Busulphan therapy is reported. The possible pathogenetic role of each of these agents is discussed.
Twenty-five scleroderma patients have been studied to evaluate blood coagulative and fibrinolytic parameters. An increase in FVIII related activities and a reduction in fibrinolytic activity was observed. These changes may be related to the endothelial damage present scleroderma patients I the consequent "in loco" activation of blood coagulation may cause the microthrombosis that is very often observed in the earliest phases of the disease.
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