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Biomedical subjects

S Stryker

Publications and source records attributed to S Stryker.

8 recordsLinked to original sources
PubMed1994

Expression of p53 protein in precursor lesions and adenocarcinoma of human pancreas.

To evaluate the incidence and stage at which p53 alterations occur in human pancreatic carcinogenesis, we examined primary and metastatic carcinomas, carcinoma in situ, and hyperplastic lesions with and without atypia for p53 protein overexpression by immunohistochemical procedure. Overexpression of p53 was observed in 40% (10/25) of primary tumors, 29% (2/7) of metastatic tumors, 36% (5/14) of carcinoma in situ, and 35% (6/17) of hyperplastic lesions. These results suggest that p53 protein overexpression is not only a common genetic alteration but also occurs very early in the development of these tumors. It is suggested that p53 overexpression can be used as a marker to identify precursor lesions that have increased potential to develop into malignant tumors.

Adenocarcinoma↗
PubMed1984

Stress and well-being: the buffering role of locus of control beliefs.

Data from the 1969 and 1971 panels of the National Longitudinal Survey of Middle-Aged Men are analyzed to assess the mediating effects of locus of control beliefs in the relationship between stressful job and economic events and psycho-physiological well-being. The analyses indicate that men with internal locus of control orientations respond more adequately to stress than do those with external locus of control beliefs. A more detailed examination of the data revealed that men with moderately internal locus of control orientations cope more effectively with stress than those whose locus of control beliefs may be classified as extreme internal, extreme external or moderately external. The theoretical implications of these findings are discussed.

Adaptation, Psychological↗
PubMed1982

Multiple mycotic aneurysms and transverse myelopathy complicating repair of aortic coarctation.

The case of an 18-year-old man with coarctation of the aorta discovered on routine physical examination and subsequently surgically repaired is reported. Four months postoperatively, aneurysms developed at the repair site and thrombosis of both femoral arteries was noted. Following an attempt to repair the aneurysm and remove the thrombi, the patient became paraplegic; Aspergillus fumigatus was found infecting the aorta and femoral vessels. After additional operations and a course of amphotericin B to control the fungal infection, the patient died of intrathoracic bleeding originating from infected, aneurysmally dilated intercostal vessels in the area of the original coarctation repair. The complicating fungal infection of the operative site and the paraplegia are discussed. This report is among the first to present a patient with fungal endarteritis complicating operation for coarctation of the aorta.

Adolescent↗
PubMed1981

Non-O group 1 Vibrio cholerae gastroenteritis associated with eating raw oysters.

A cluster of five cases of non-O group 1 (non-O1) V. cholerae gastroenteritis occurred in one Florida locality during November 1979. Clinical findings included nausea, vomiting, and abdominal cramping in all affected persons; two had bloody diarrhea. All five persons gave a history of eating raw oysters within four days of onset of illness. A case-control study statistically associated the eating of raw oysters with development of illness (p = 0.0008); this finding was confirmed by a retrospective cohort study of patients hospitalized for diarrhea (p = 0.0001). Non-O1 V. cholerae organisms were isolated from oysters and water samples taken from areas where ill persons had obtained their oysters. In at least one instance the same serotype was isolated from a patient's stool specimen and from the water where the patient had obtained oysters. Non-O1 V. cholerae infection must be considered in the differential diagnosis of shellfish-associated gastroenteritis.

Adult↗
PubMed1980

Mesenteric tumefactions.

Mesenteric tumefactions comprise a group of non-neoplastic conditions that present as an intra-abdominal mass. Symptoms vary from none to obstruction of the gastrointestinal tract. Histologic examination reveals dystrophy, fibrosis, or inflammation of the mesenteric fat. Despite a large number of descriptive terms currently in use, this study suggests that all these lesions are part of a single clinical and histologic continuum.

Adipose Tissue↗