Biomedical subjects

S Stuckey

Publications and source records attributed to S Stuckey.

21 records · Page 2Linked to original sources

PubMed1983

Colorectal carcinoma. Evidence for circulating CEA-anti-CEA complexes.

Significant increments in measurable plasma CEA were effected by 2.5 M MgCl2 elution from putative circulating CEA-anti-CEA complexes in 11 of 15 patients with disseminated colorectal cancer and in five of ten patients with a high probability of having subclinical disease (Dukes'C category). Following 2.5 M MgCl2 elution, IgG from a patient with a high CEA increment effected a higher specific binding to 125I-CEA than a similar IgG eluate from a patient with a negligible increment in measurable CEA. These data suggest that CEA is autoimmunogenic and may result in circulating CEA-anti-CEA complex formation. The clinical implications of such complexes in the diagnosis and monitoring of patients with colorectal cancer remain to be determined.

Antigen-Antibody Complex↗

PubMed1982

Reliability of measuring trunk motions in centimeters.

A method of measuring trunk motion and two related motions using a tape measure and a stepstool was developed by physical therapists at our hospital. The purpose of this study was to assess the reliability of this method. Three repetitions of six motions performed by 24 subjects were each measured by three physical therapist raters on two separate days. The motions were forward bending, backward bending, right side bending, right rotation, right straight leg raising, and right prone knee bending. Reliability, standard deviation, and standard error were calculated for each motion. Only forward bending exhibited good single measurement reliability. Reliability coefficients for all motions were higher for the average of three successive measurements or for the measurement of a motion on successive days by the same rater. Measurements of rotation and straight leg raising, despite the improvement, continued to have low reliability. Analysis of variance was used to determine the significance of the differences between means for each motion across three raters, three repetitions, and two days. By looking at the analysis of variance and reliability estimates together, the authors identified two types of constant error affecting the data.

Adult↗

PubMedDate not supplied

Hyperintensity of the middle cerebellar peduncles on fluid-attenuated inversion recovery imaging: variation with age and implications for the diagnosis of multiple system atrophy.

BACKGROUND AND PURPOSE: T2 hyperintensity of the middle cerebellar peduncle (MCP) is described in a number of diseases, including multiple system atrophy (MSA). We hypothesize that mild MCP hyperintensity on fluid-attenuated inversion recovery (FLAIR) imaging can be a normal finding. To our knowledge, a detailed study of the prevalence of this finding in various age groups with the FLAIR sequence has not been described. METHODS: One hundred twenty-two patients underwent an axial FLAIR examination of the brain as part of either a hearing loss or tinnitus work-up (ie, to exclude an acoustic neuroma or a retrocochlear cause). Subjects aged 15-78 years were included to reflect an even spread through the decades and were divided into 6 age groups. A radiologist and an MR imaging fellow graded the examinations subjectively, blinded to age: 0 for normal or 1 for the presence of MCP hyperintensity if the increased signal intensity was greater than that of adjacent pons and cerebellar white matter. Spearman rank correlation test of MCP hyperintensity with age and analysis of variance (ANOVA) were performed. RESULTS: Of 122 patients, we identified 17 with MCP FLAIR hyperintensity. None of these patients had a clinical condition that could cause MCP hyperintensity. MCP hyperintensity did not show a statistically significant correlation with age (r = 0.05, P = .62). Patients were divided into 6 age groups, and ANOVA showed no statistically significant difference in the incidence of MCP hyperintensity between different age groups (P = .95). However, results were highly reproducible with excellent interobserver correlation (r = 0.97, P < .001). CONCLUSIONS: Mild MCP FLAIR hyperintensity can occur normally, and this finding shows no relationship with age.

Adolescent↗