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Biomedical subjects

S Sutton

Publications and source records attributed to S Sutton.

At least 109 records · Page 6Linked to original sources
PubMed1978

The effect of specific antiserum on the resistance of Neisseria gonorrhoeae to intracellular killing by phagocytes of human blood.

The high natural resistance of gonococci showing a characteristic 'double highlight' (DH) colonial morphology (Penn, Veale & Smith, 1977b) to intracellular killing by human phagocytes was markedly reduced by addition of rabbit antiserum to the phagocytosis medium or by preincubation of organisms with antiserum. Antisera raised to three different DH gonococcal strains showed a complex pattern of specificity in phagocytosis tests with the homologous organisms and three other DH strains. The effect of antiserum could be neutralized by adsorption with intact organisms or with extracts, prepared ultrasonically, of the homologous strain. Antiserum also promoted the intracellular killing of a strain which had a 'single highlight' colonial morphology (Penn et al., 1977b) and a low natural resistance to phagocytic killing, but adsorption with this strain neutralized the antiserum less consistently than the DH strain. The neutralization of antiserum-mediated promotion of intracellular killing by extracts of organisms naturally resistant to such killing may provide an assay for the aggressins responsible for this resistance.

Adsorption↗
PubMed1976

Adamantane and protoadamantanealkanamines as potential anti-Parkinson agents.

The synthesis of 2-halo-1-adamantanemethanamines, 4-protoadamantanemethanamines, and 4-protoadamantaneamines is described. The anti-Parkinson activity of these amines in terms of reversal of reserpine-induced catalepsy in rats has been evaluated and compared with amantadine. 2-Bromo- and 2-chloro-1-adamantanemethanamines are shown to be twice as active as amantadine.

Adamantane↗
PubMed1975

Auditory signal detectability and facilitation of simple reaction time in psychiatric patients and non-patients.

Patients diagnosed on the basis of structured interviews as having affective psychoses were less sensitive in detecting the presence of a transient auditory signal than were schizophrenic patients or non-patients. Patients with affective psychoses also benefited more (their reaction time was more reduced) than the other two groups from the presence of a second auditory transient.

Acoustic Stimulation↗
PubMed1972

Evoked potential correlates of response criterion in auditory signal detection.

The amplitude of a late positive component of the average evoked potential recorded from the human scalp varied systematically as a function of the observer's response criterion as defined within the context of signal detection theory. With signal intensity invariant, the P(3), component of the evoked potential increased monotonically with increasing strictness of the criterion. The results are viewed as supporting the signal detection theory approach to the analysis of discrimination behavior as well as providing further evidence of the sensitivity of P(3) to the manipulation of psychological variables.

Auditory Perception↗