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Biomedical subjects

S Suwanjutha

Publications and source records attributed to S Suwanjutha.

31 records · Page 2Linked to original sources
PubMed1990

Haemophilus influenzae and Streptococcus pneumoniae in children with acute respiratory infection.

The incidence of Haemophilus influenzae and Streptococcus pneumoniae in children with acute respiratory infection (ARI) under 5 years was carried out by throat swab culture, blood culture, body fluid or tissue culture in 688 patients from a community, 744 patients from a teaching hospital in Bangkok, 766 normal children from the community and 303 children from a hospital well baby clinic. H. influenzae was found in the throats of 15-20% of patients and in the throats of 4-6% of normal children (p less than 0.001 for both hospital and community patients). Only 12/332 strains (3.6%) of H. influenzae were type b. The rest of H. influenzae were non type b. The most common biotype of H. influenzae non type b was biotype II. S. pneumoniae was found in hospital patients in highly significant numbers compared to the controls (12% vs 4%). No significant difference was observed in strains from the community patients.

Bacterial Typing Techniques↗
PubMed1985

The role of ketotifen in children with recurrent bronchitis.

The efficacy and safety of ketotifen in the treatment of recurrent bronchitis were studied in twenty Thai children with an average age of 5.3 years. Symptoms studied were cough, hypersecretion and wheezing and 4-point rating scores were assigned to each of the symptoms with regard to their frequency, severity and duration. Score per dose of the symptomatic agents used was also given. The symptoms and the use of symptomatic agents were recorded during a full year prior to ketotifen treatment and during a further full year study period. PEFR measurement was performed in the children above the age of 6 years at 2-weekly intervals under the supervision of the authors at the clinic. Assessment of efficacy was done by comparing monthly symptom scores and medication scores during the study period with the mean value of the previous year. Thirteen children received ketotifen for the whole year while seven children who were almost symptom-free after 4 months ketotifen treatment, were then only observed for a further 8 months. At the end of the study period, ketotifen treatment was rated very good and good in 85% of children, satisfactory in 10% and poor in 5%. Drowsiness was the only side-effect reported in a few cases but then only initially. There were no abnormalities in any laboratory parameters studied.

Bronchitis↗
PubMedDate not supplied

A study of nonbacterial agents of acute lower respiratory tract infection in Thai children.

From January 1986 to December 1987, 596 children less than 5 years of age with lower respiratory tract infection (LRI)--manifested as laryngitis, croup, bronchitis, bronchiolitis, and pneumonia--were studied for evidence of infection with respiratory tract viruses Mycoplasma pneumoniae, and Chlamydia trachomatis. Of the 596 children in the study, 315 were ambulatory and 281 were hospitalized. Virologic studies included isolation and rapid diagnosis of virus from specimens of nasopharyngeal aspirate (NPA) and serologic studies of blood samples. Cultures of NPA for C. trachomatis were performed for children less than 6 months of age who had pneumonia. Of the LRI cases, 45% were associated with viral infections of the respiratory tract and 12.1% were associated with C. trachomatis. Respiratory syncytial virus (RSV) accounted for 45.2% of infections with viral agents and was associated with acute bronchitis, acute bronchiolitis, and pneumonia. Parainfluenza type 3 virus was the most common virus found in conjunction with laryngitis and croup. The incidence of infections due to RSV peaked in July and August, while that of infections due to parainfluenza viruses peaked in February and March; influenza viruses and adenoviruses were isolated throughout the year.

Acute Disease↗
PubMedDate not supplied

A community-based study of acute respiratory tract infection in Thai children.

A 2-year longitudinal study was conducted among the population of a socioeconomically depressed urban community in Bangkok, Thailand, from January 1986 through December 1987 to determine the incidence, etiologic agents, and risk factors associated with acute respiratory tract infection (ARI) in children less than 5 years of age. Data were obtained for a total of 674 children, who were visited twice weekly for detection of signs and symptoms of ARI. During the first year of the study, throat-swab specimens were obtained for bacterial culture from both ill and healthy children and a nasal wash was performed on mildly ill children for detection of virus. During both years of the study, nasopharyngeal aspiration for identification of virus was performed for children with more severe infection. The overall incidence of ARI was 11.2 episodes per child-year. The highest (14.9) and lowest (8.8) rates per child-year occurred in age groups 6-11 months and 48-59 months, respectively. Respiratory syncytial virus, parainfluenza virus, adenovirus, Streptococcus pneumoniae, and Haemophilus influenzae were the prevalent pathogenic agents identified. Factors associated with higher risk of ARI were low family income, working mothers, mothers with allergies, chronic malnutrition, and crowding in the home.

Acute Disease↗
PubMedDate not supplied

A hospital-based study of acute viral infections of the respiratory tract in Thai children, with emphasis on laboratory diagnosis.

The hospital-based study described here examined the viruses found in 738 children less than 5 years old who presented at Ramathibodi Hospital, Bangkok, Thailand, from January 1986 to December 1987 with acute respiratory tract infections. Three methods for detection of viral infection are compared: direct examination of epithelial cells of the respiratory tract with the use of fluorescent antibody staining, isolation of virus, and measurement of antibody in acute- and convalescent-phase sera. Viral infections were found in 44.7% of the study population. Diagnosis by the examination of epithelial cells with the fluorescent antibody staining procedure was found to have several deficiencies; however, this technique was the most sensitive for diagnosis of infection due to respiratory syncytial virus. Isolation of virus was the best method for identification of adenoviruses, parainfluenza 1 and 3 viruses, and influenza B virus. Problems associated with serodiagnosis included failure to obtain specimens of convalescent-phase blood in 24.5% of cases and insensitivity of serodiagnosis for young children except for the identification of antibody to influenza A virus. The combination of all three tests yielded the best rate of detection of virus.

Acute Disease↗