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S Synek

Publications and source records attributed to S Synek.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Ultrastructural changes in the vitreous body in diabetic retinopathy].

The authors investigated by transmission electron microscopy bioptic specimens obtained during pars plana vitrectomy. In the findings phagocytozing cells predominate. Due to cell damage accurate typing is difficult. The authors discuss the causes and extent of cellular damage. From morphological findings the conclusion can be drawn that in the histological picture macrophages, hyalocytes and damaged collagen fibrils predominate.

Adolescent↗
PubMed1990

[Pathogenesis of disorders of transparency of the optic media of the eye. VI. Transmission electron microscopy in chalcosis of the lens].

By means of transmission electron microscopy in the chalcotic lens ultrastructural changes were probed which can be divided into specific and non-specific ones. Specific findings include proliferation of vacuoles in the cytoplasm, development of oedema of lenticular fibres and dilatation of intercellular spaces. For specific findings intercellular chalcosomes in the shape of copper crystals are typical. Copper crystals are dispersed also in the cytoplasm in formations lined by the membrane. Non-specific changes in the chalcotic lens can be classified as degenerative changes in the lenticular capsule, which is divided into segments.

Animals↗
PubMed1989

Ultrastructure of the vitreous body of the rabbit.

Examination in the scanning and the transmission electron microscope showed three morphologically and structurally different types of cells in the vitreous body of the healthy rabbit eye: 1. cells with numerous cytoplasm processes, whose high metabolic activity is represented by the presence of a large number of organelles and which are capable of synthesizing fibrillar material; 2. elongate cells with a flattened nucleus, with long, narrow cytoplasm processes arising from both their poles and with only a few organelles in their cytoplasm; 3. large spherical cells with structureless contents, whose nucleus and few organelles are situated below the cell membrane. The organized component of the intercellular matter of the rabbit vitreous body is composed of collagen fibrils with a very variable diameter (24-180 nm), The collagen fibrils form the basis of the three-dimensional skeleton of the intercellular matter of the vitreous body.

Animals↗
PubMed1989

[Pathogenesis of disorders of transparency of the optic media of the eye. III. Quantitative detection of copper in relation to the ultrastructure of the vitreous body in chalcosis].

The authors elaborated a new analytical micromethod for the detection of elements in morphologically investigated ultrastructures of the vitreous body. For the investigation of quantitative ultrastructural changes electron microanalysis (EMA) was used, combined with raster electron microscopy (REM). Using this method, the authors proved ultrastructural changes of the vitreous body by selective uptake of copper in the trabecular collagen fibres of the vitreous body in experimental chalcosis. From the results ensues that copper does not diffuse in the vitreous body in a homogeneous manner but aggregates in irregular agglomerations of precipitates and crystals. The different quantitative detection of copper in different parts of the same specimen is according to the authors due to the heterogeneous affinity of ultrastructural portions of the vitreous body for copper.

Animals↗
PubMed1989

[Work capacity evaluation in patients after surgery for detached retina].

The authors investigated the enlistment into work in patients after operation of detached retina at the Ophthalmological Clinic in Brno in 1985. From the results of the work it is apparent that the risk of relapse in conjunction with unsuitable work after operation is practically nil. Socio-economic aspects of patients who before operation suffered from some predisposing eye disease are more affected. The authors recommend systematic screening and dispensary care, in particular during the period when these people decide on their future occupation, i. e. already in primary school.

Adolescent↗
PubMed1989

[Pathogenesis of transparency disorders of the optical environment of the eye. IV. Electron microscopy study of the vitreous body in chalcosis].

The authors proved, based on electron microscopic analysis that the vitreous body of the rabbit creates under physiological conditions a regular network of collagenous fibrils with a different cell population. The cells can be divided into three basic types: 1. Large cells with a lobular nucleus and well differentiated cytoplasm and multiple organelles which ensure a high metabolic activity. 2. The second type are cells of an elongated shape with an oval nucleus surrounded by a thin layer of cytoplasm with a small amount of organelles. 3. The third type are large globular cells with a homogeneous structureless mass. The basic cytoplasm with the nucleus and a negligible amount of organelles is pushed to the cell surface and thus forms a thin layer beneath the plasmalemma. Contrary to the pathologically altered vitreous body, the authors did not detect on the sound vitreous body any phagocytosing cells. On the other hand, the long-term effect of copper in experimental chalcosis markedly alters the cytological character of the structure of the vitreous body. Cell types typical for a sound vitreous body were not found in the affected eye in chalcosis. In addition to rare destroyed cells containing autophagosomes of varying size with incomplete plasmalemma at some sites there is the important finding of two different forms of phagocytes in the pathological vitreous body: 1. Neutrophil granulocytes and 2. Macrophages containing large phagosomes in the cytoplasm. Their function is to eliminate destroyed tissues and engulfing of copper particles.

Animals↗