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Biomedical subjects

S T Chang

Publications and source records attributed to S T Chang.

42 records · Page 3Linked to original sources
PubMedDate not supplied

Sulbactam/ampicillin followed by oral treatment with sultamicillin for medical and surgical infections.

This study was conducted to evaluate the efficacy and safety of intravenous sulbactam/ampicillin followed by oral sultamicillin. Parenteral sulbactam/ampicillin was administered for 7 to 14 days to 152 in-patients with moderate to severe infections. All patients were treated with sulbactam/ampicillin, but only 140 patients received oral sultamicillin therapy. Eighty-nine men and 63 women participated in this study. Infections included intraabdominal (42 cases), respiratory tract (52 cases), skin and soft tissue (29 cases), urinary tract (16 cases), and miscellaneous infections (14 cases) that included typhoid fever, gastroenteritis, septicemia, and surgical wound infection. Six (4%) patients reported six study drug-related adverse experiences. Gastrointestinal side effects were most common and included epigastric burning and indigestion. Diarrhea was not reported and no patient discontinued drug therapy because of an adverse event. Laboratory abnormalities were infrequent and clinically insignificant. Overall, 98% of the 114 evaluable patients achieved clinical cure or improvement following treatment with sulbactam/ampicillin and sultamicillin. Cured or improved patients in each diagnostic group were 97% for intraabdominal infections, 100% for respiratory tract infections, 100% for skin and soft tissue infections, 100% for urinary tract infection, and 91% for other types of infections. Only 2 (2%) patients were judged to be treatment failures. Microbiologic efficacy, or eradication, was 86% overall, ranging from 75 to 100%. Persistence of pathogens occurred in 5%, and eradication with development of a superinfection occurred in 4%. Fifty-seven percent (30/50) of the isolates tested were resistant to ampicillin alone whereas only 21% (9/42) were resistant to sulbactam/ampicillin (p = 0.002).(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMedDate not supplied

Unfolding and conformational distributions during protein precipitation.

The association of misfolded proteins, or aggregation, is a critical problem in a number of human diseases as well during the expression, refolding, formulation, and delivery of therapeutic proteins. In this study, we investigate lysozyme precipitation with hydrogen exhange using nuclear magnetic resonance (NMR) and mass spectrometry (MS). We show that MS can reveal the presence of conformational distributions, albeit without the detailed structural information afforded by NMR. Further, we find that increases in precipitant concentration alter the structure and composition of precipitates. The selective unfolding of one portion of the protein in these precipitates is correlated with hydrogen exchange patterns observed under nonprecipitating conditions and in other studies of lysozyme.

Chemical Precipitation↗
PubMedDate not supplied

The application of an Actel field programmable gate array in the design of an ECG RR interval recorder.

Field Programmable Gate Arrays (FPGAs) allow digital circuitry to be integrated on to a single device without the long time penalty incurred with mask programmable Application Specific Integrated Circuits (ASICs). This makes FPGA technology an attractive option to engineer involved in designing digital circuitry where space is at a premium. Furthermore, the relatively low cost of FPGAs at low volume, compared to mask programmable ASICs make them an excellent prototyping option for designers who are considering low cost volume production with mask programmable ASICs. There are several different types of FPGAs available which thus creates confusion for prospective users uncertain of their relative benefits. This paper serves as an introduction to FPGA technology and the stages involved in implementing a design, via the application of an Actel FPGA to the development of an ambulatory long term electrocardiogram (ECG) based RR interval recorder.

Biomedical Engineering↗
PubMedDate not supplied

Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice.

Two lectins isolated from the mushroom Tricholoma mongolicum stimulated the production of nitrite ions by macrophages in normal and tumor-bearing mice. Both lectins exhibited negligible mitogenic activity toward T-cells or splenocytes from normal mice in vitro when compared with Con A. Similarly, T-cells from sarcoma-bearing mice treated with the lectins did not exhibit a mitogenic response different from that of the control. However, T-cells from normal lectin-treated mice demonstrated a reduced mitogenic response when compared with the control. In mice the growth of sarcoma 180 cells in the peritoneal cavity was inhibited and the life-span was prolonged by the two lectins.

Animals↗