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Biomedical subjects

S T Han

Publications and source records attributed to S T Han.

11 recordsLinked to original sources
PubMed1990

[Effects of calcium ion on contractile response of guinea-pig gallbladder muscle strip to agonists].

The effects of calcium ion on the contractile response of gallbladder muscle strip (GBMS) in guinea pigs to acetylcholine, carbachol and caerulein were investigated by method of isotonic contraction and by RIA of cGMP and cAMP in the tissue. It was shown that the contractile response of GBMS to these agonists was stronger in Krebs solution than that in the calcium-free solution. In calcium-free solution, EDTA-zero calcium solution or verapamil-Krebs solution, the contractile response of GBMD was decreased to about 30% of the control (P less than 0.01). Verapamil significantly decreased carbachol induced enhancement of cGMP and cAMP of gallbladder tissue (P less than 0.01 or 0.05). The results suggest that both extra-and intra- cellular calcium take part in the contractile response of GBMS to agonists.

Acetylcholine↗
PubMed1982

Evaluation of a miniature CdTe detector for monitoring left ventricular function.

A miniature CdTe probe interfaced to a microcomputer was used to measure left ventricular ejection fraction (LVEF) in 25 patients. LVEF obtained with the CdTe module, in the beat-to-beat mode, or the integrated gated mode agreed well with LVEF obtained with a gamma camera (r = 0.80; r = 0.82 respectively). Similarly, LVEF by CdTe probe agreed with LVEF obtained by gated equilibrium studies performed with a computerized NaI probe. The CdTe probe can provide comparable measurement of LVEF at a fraction of the cost of a camera-computer system and, being small and lightweight, the CdTe probe is adaptable for monitoring patients in intensive care facilities.

Adult↗
PubMed1982

Performance of a fully automated program for measurement of left ventricular ejection fraction.

A fully automated program developed by us for measurement of left ventricular ejection fraction from equilibrium gated blood pool studies was evaluated in 130 additional patients. Both 6-min (130 studies) and 2-min (142 studies in 31 patients) gated blood pool studies were acquired and processed. The program successfully generated ejection fractions in 86% of the studies. These automatically generated ejection fractions were compared with ejection fractions derived from manually drawn regions of interest. When studies were acquired for 6-min with the patient at rest, the correlation between automated and manual ejection fractions was 0.92. When studies were acquired for 2-min, both at rest and during bicycle exercise, the correlation was 0.81. In 25 studies from patients who also underwent contrast ventriculography, the program successfully generated regions of interest in 22 (88%). The correlation between the ejection fraction determined by contrast ventriculography and the automatically generated radionuclide ejection fraction was 0.79.

Cardiac Output↗