DNA ploidy of thyroid lesions.
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Biomedical subjects
Publications and source records attributed to S T Hayne.
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Florid oral papillomatosis presents a picture of multiple squamous papillary lesions found in the oral pharynx. Multiple risk factors associated with the development of these lesions include possible association with papilloma virus, the use of tobacco products, and chronic inflammation or irritation such as that caused by poorly fitted dentures. The major risk factor of these benign squamous lesions is the dedifferentiation into a well-differentiated verrucous carcinoma. However, treatment in the early stage of the disease is usually successful. Surgical excision has been favored as the initial approach. The use of radiotherapy for verrucous carcinoma is controversial. In numerous reported cases dedifferentiation of the tumor has produced an anaplastic squamous cell carcinoma. More recent articles, however, indicate that the risk for dedifferentiation of verrucous carcinoma due to radiotherapy may be overstated.
Polycythemia vera and primary hyperparathyroidism is diagnosed in a patient with dysplastic nevus syndrome. A 59-year-old white man is noted to have numerous pigmented lesions found predominantly over the upper aspect of the back and chest. A biopsy revealed the atypical nevi found in dysplastic nevus syndrome. Over a 13-year period, three superficial spreading malignant melanomas were excised. The patient subsequently had polycythemia vera and primary hyperparathyroidism develop. Atypical pigmented skin lesions were not seen in family members, although two family members died of metastatic malignant neoplasms, one from endometrial carcinoma and the second from prostatic adenocarcinoma.
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An infant boy born to an asymptomatic mother was found to have typical cutaneous and serologic findings of the neonatal lupus syndrome. Anti-Ro and anti-La antibodies were detected in both the mother and the child. Evaluation of the maternal grandmother who had been diagnosed with "lupus" was nondiagnostic.
The active phase of herpes zoster can be predicted from the length of time it takes for all the vesicles to erupt. A case is reported in which cimetidine therapy appeared to reduce the expected length of the active phase from 35 days or longer to 10 days.
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