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Biomedical subjects

S T Leslie

Publications and source records attributed to S T Leslie.

6 recordsLinked to original sources
PubMed1988

Determination of morphine in human plasma by radioimmunoassay utilising a preliminary liquid-solid extraction.

Numerous assays are available for the pharmacokinetic study of morphine. Two of these methods are compared with a new assay procedure, which involves a solid-phase extraction to clean up human plasma before radioimmunoassay allowing the determination of morphine levels to a sensitivity of 1 mugl(-1). Data are presented to show the importance of correct method choice if clinical studies are to be used in pharmacokinetic interpretations.

Journal Article↗
PubMed1978

A controlled release papaverine tablet (Papacontin): a study in normal volunteers.

1. A controlled release tablet containing 300 mg of papaverine hydrochloride was compared with a capsule containing the same dose. 2. The in vitro release pattern showed a steady dissolution of the tablet, with release of the papaverine over 10 h, whereas the capsule release time was 40 min. 3. Plasma levels in volunteers who were given the tablet showed a rapid rise to therapeutic levels (150-300 ng/ml) within 1 h, and maintenance of these levels for 10-12 h, with no accumulation on repeated 12 hourly dosage. Administration of the capsule produced early peaking and a subsequent rapid fall in plasma levels.

Delayed-Action Preparations↗