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Biomedical subjects

S T Roxburgh

Publications and source records attributed to S T Roxburgh.

11 recordsLinked to original sources

Blindness in patients with diabetes who have been screened for eye disease.

PURPOSE: Detection of diabetic retinopathy by screening is a major public health concern. Fundus photography has been shown to be a useful screening tool for the detection of diabetic retinopathy. In this paper the authors assess the incidence of blind and partially sighted registration due to diabetic eye disease in patients screened by a mobile fundus photography unit and identify the factors that contributed to loss of vision in the registered group. METHODS: A retrospective review of blind and partially sighted registrations between 1990 and 1995 was performed in a diabetic population screened by a mobile fundus photography unit in a region with a population of 390,000. The incidence of blind and partially sighted registration in the screened diabetic population was calculated. In the registered group, cause of visual loss, accuracy of photograph reporting, delay in laser treatment, adequacy of laser treatment and non-attendance rates at ophthalmic clinics were assessed. RESULTS: Of the 5390 patients screened by the mobile unit over 6 years, 68 (210 per 10(5) patient-years) were registered blind or partially sighted, but in only 17 patients (53 per 10(5) patient-years) was this as a result of diabetes. The factors contributing to loss of vision were found to be failure of laser treatment, rapidly progressive disease and poor patient attendance. CONCLUSIONS: As the majority of visual impairment in patients with diabetes is not due to diabetic retinopathy, this has important implications for screening programmes and may make the St Vincent Declaration targets difficult to achieve. The rate of new blind and partially sighted registration due to diabetes in the screened population was low at 53 per 10(5) patient-years (95% confidence interval, 29-76).

Adult↗

A new method of image analysis of fluorescein angiography applied to age-related macular degeneration.

Quantitative analysis of retinal and choroidal abnormalities using current photographic techniques is complex and laborious. Digital image analysis techniques using the scanning laser ophthalmoscope overcome many of the problems with present techniques and allow reliable quantitation. A prerequisite of quantitation is accurate image acquisition and registration. The authors describe a reliable method of image analysis and apply it to the quantitation of hyperfluorescence in scanning laser fluorescein angiograms of different forms of age-related macular degeneration. Retrospective analysis of scanning laser fluorescein angiograms obtained using a standardised technique was undertaken. Eighty-six angiograms from patients with age-related macular degeneration were analysed and categorised as dry maculopathy, geographic atrophy of the retinal pigment epithelium, retinal pigment epithelial detachment (PED) or subretinal neovascularisation (SRNV). Fluorescein characteristics of both SRNV and PED showed a characteristic pattern of fluorescence. The advantages and disadvantages of the technique are discussed.

Aged↗

Vitrectomy for diabetic eye disease.

Thirty four eyes which underwent vitrectomy because of diabetic proliferative retinopathy were reviewed. The overall success rate of the operation was 62%. Excluding table top retinal detachments, which all did badly, the success rate was 72%. Grading by ultrasound was found to be helpful in; (a) planning surgical approach, (b) assessing visual outcome. The most common late complication was cataract. Extracapsular cataract extraction with implantation was found to be successful in these cases.

Adult↗

Videofluoroscopy in macular disease.

Fluorescein Angiography has contributed immensely to our understanding and management of macular disease. Ridley first introduced the concept of television ophthalmoscopy and in 1973 Van Heuven and Schaffer reported the value of videofluoroscopy using a low light level system and an image intensifier. Major advances in electronic imaging technology since then have permitted high quality videofluoroscopy to be developed in particular the integral silicone intensified tube (SIT) allowed ultra low light levels to be recorded. A videofluorography system has been in routine use in our department for the last six years and we have found it to have certain advantages over conventional photography in macular disease. In this presentation we demonstrate some of these.

Fluoroscopy↗

Retinal break formation following contrecoup trauma: case report.

A previously healthy 38-year-old woman was involved in a road traffic accident resulting in severe commotio retinae. Subsequently extramacular retinal dissolution was noted (not previously described). The patient was treated by closed intraocular microsurgery with a successful anatomical and functional result.

Adult↗

Atypical retinitis pigmentosa with hypophosphatasia.

Hypophosphatasia is a rare inborn error of metabolism. Ocular signs of hypophosphatasia previously described are blue sclera, band keratopathy, conjunctival calcification, cataract, optic atrophy and the complications of craniostenosis. This paper reports the association of a pigmentary dystrophy similar to rod/cone dystrophy with hypophosphatasia.

Adult↗