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Biomedical subjects

S T Sinatra

Publications and source records attributed to S T Sinatra.

18 recordsLinked to original sources
PubMed1998

Relative bioavailability of coenzyme Q10 formulations in human subjects.

The relative bioavailability of typical commercially available forms of coenzyme Q10 (CoQ10) was compared with that of Q-Gel, a new solubilized form of CoQ10, in human subjects in two separate trials. In the first, standard softgel capsules containing CoQ10 suspension in oil, powder-filled hardshell capsules and powder-based tablets were tested along with Q-Gel using a daily dosage of 120 mg for three weeks. The baseline plasma CoQ10 values were all very tight (0.50-0.52 microgram/mL) and after three weeks the values were 1.37, 1.63 and 1.60 micrograms/mL for the first three products and 3.31 micrograms/mL for Q-Gel. The relative bioavailability calculated using the areas under the plasma CoQ10 curve (AUC) were (micrograms/mL x time in days) 7.16 (100%), 8.97 (125%), 9.19 (128%) and for Q-Gel 22.86 (319%). The second trial, carried out to replicate the findings in the first, employed only two groups, namely the standard softgel capsules containing the suspension and Q-Gel, and the duration was extended to four weeks. Plasma CoQ10 values were: baseline 0.40 and 0.38 and after four weeks 1.26 and 2.80; the corresponding AUCs were: 8.33 (100%) and 22.75 (273%). Thus, the data from both the trials show that Q-Gel, the new solubilized form of CoQ10, is vastly superior to typical commercially available preparations of CoQ10. This means much lower doses of Q-Gel will be required to rapidly reach and maintain adequate blood CoQ10 values than with any of the other currently available products.

Adult↗
PubMed1997

Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration.

Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac complications in congestive heart failure. However, dosing, clinical application, bioavailability and dissolution of CoQ10 deserve careful scrutiny whenever employing the nutrient. The assessment of blood levels in 'therapeutic failures' appears warranted.

Aged↗
PubMed1995

Free radicals, oxidative stress, oxidized low density lipoprotein (LDL), and the heart: antioxidants and other strategies to limit cardiovascular damage.

The heart is the most susceptible of all the organs to premature aging and free radical oxidative stress. Clinical research has clearly documented the role of free radical damage and the progression of numerous degenerative diseases, particularly cardiovascular disease. This may be the result of acute ischemia-reperfusion injury, endothelial damage of hyperhomocysteinemia, as well as chronic oxidative damage secondary to lipid peroxidation. Fortunately, although highly responsive, and therefore vulnerable to the effects of oxidative stress, the heart is also receptive to the benefits of targeted phytonutrients, antioxidants, and nutritionals. The effects of antioxidant nutrients have been extensively evaluated in epidemiological, population, and clinical studies. Phytonutrients such as the natural flavonoids and carotenoids found in fresh fruits and vegetables or vitamins C, E, and beta-carotene have powerful antioxidant effects. In addition, minerals like selenium and nutrients such as coenzyme Q10 will minimize free radical risk and optimize a favorable outcome from the ubiquitous presence of oxidative stress on the cardiovascular system. The B complex, particularly folic acid, B12, and B6 are also essential in the prevention of hyperhomocysteinemia, another major risk factor for the circulatory system. Measures to minimize accumulation of heavy metals in the body, especially iron and copper, which are capable of initiating adverse free radical reactions, will also help to assuage oxidative stress. Thus, the combination of a healthy diet supplemented with antioxidants and phytonutrients may be useful in the prevention and promotion of optimum cardiovascular health.

Antioxidants↗
PubMed1991

Middle age male distance runners: physiological and psychological profiles.

This study investigated 4 research questions addressing exercise capabilities and psychological characteristics of middle-age (30 to 50 years) male runners. Subjects provided an extensive running history, completed the Multidimensional Anger Inventory, completed the Myers-Briggs Type Indicator, and performed a treadmill running test to volitional exhaustion. Another aspect of the study compared anticipatory and posttest reactions to the treadmill test experience to actual test results. The findings suggest that these runners have common personality profiles, that long-term involvement in running and training is associated with a positive sense of self, and that lifelong aerobic exercise is associated with high cardiovascular fitness. Although the research design does not permit causal or predictive conclusions, the study provides valuable additional baseline information for physicians and fitness professionals who serve middle aged male runners.

Adult↗
PubMedDate not supplied

Alternative medicine for the conventional cardiologist.

Today's cardiologist faces a daily dilemma concerning how best to refer patients for diagnostic procedures and how to select surgical and/or pharmaceutical interventions based on those test results. But the evaluations they order and the treatments they select may actually create unnecessary risks for the patients that are out of proportion to the benefits they experience. Continuing technological advances, although necessary, add to the complexity of the decision-making process. As increasing numbers of our patients are turning to alternative therapies, a paradigm shift is required in medicine to evaluate the efficacy of these therapies and effectively incorporate them into the conventional medical model. In this review, alternative treatment options are highlighted, with emphasis on understanding the psychoemotional component of heart disease and the use of modern "nutriceutical" agents. Accepting complementary therapies as equally judicious treatment interventions requires a shift in perspectives that may allow for more integrated care strategies for those who have been seeking a more expanded approach to heart disease.

Antioxidants↗