Myelopathy in spondylometaphyseal dysplasia.
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Adult↗
Biomedical subjects
S Takashi
Publications and source records attributed to S Takashi.
Eosinophil active cytokines and surface analysis of eosinophils in Churg-Strauss syndrome.
There are few reports regarding the measurement of cytokines and surface analysis of eosinophils in Churg-Strauss syndrome (CSS). To examine the pathophysiology of CSS, concentrations of cytokines in serum and bronchoalveolar lavage fluid (BALF), and surface antigens on peripheral blood eosinophils were analyzed in five patients with CSS. Concentrations of cytokines (interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-3 (IL-3), interleukin-5 (IL-5) and granulocyte/macrophage colony stimulating factor (GM-CSF) were measured using ELISA. Surface antigens on eosinophils in peripheral blood were analyzed using flow cytometry. A concentration of interleukin-5 (IL-5) and TNF-alpha in serum was detected in five cases; however IL-1 beta, GM-CSF, and IL-3 were detected in 3 of 5, 2 of 5, and 1 of 5 patients, respectively. In BALF, TNF-alpha and IL-5 were detected in 2 of 3 and 1 of 3 patients, respectively; however, neither IL-1 beta, GM-CSF, nor IL-3 was detected in any. Newly expressed surface antigens such as CD25, CD4, and CD69 were observed on peripheral blood eosinophils in five cases. CD54 and HLA-DR were expressed in 4 of 5 and 3 of 5 patients, respectively. Eosinophils in peripheral blood are activated to various degrees, possibly depending on cytokine stimulation. This eosinophil activation may be related to the clinical stage of CSS.
Adult↗
Acetabular development after Salter's innominate osteotomy for congenital dislocation of the hip: evaluation by three-dimensional quantitative method.
Three-dimensional assessment of acetabular coverage of the femoral head was made for 30 patients with unilateral congenital dislocation of the hip undergoing Salter's innominate osteotomy for residual subluxation. Radiologic examinations were serially performed until bone maturity, and the final acetabular coverage was evaluated by a quantitative method with a computer program developed by Konishi and Mieno. At the final examination, no significant differences between the involved and unaffected sides were found in terms of the total coverage or posterior-half coverage. The anterior-half coverage and the anterior-to-posterior ratio of the involved side were significantly greater (73.7 and 97.8%, respectively) than the values for the unaffected side (68.8 and 90.8%). In conclusion, the anterior inclination of distal fragment that is obtained by Salter's innominate osteotomy continues until bone maturation. However, remodeling of the posterior part of the acetabulum occurs by growth after the operation.
Acetabulum↗