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Biomedical subjects

S Tchang

Publications and source records attributed to S Tchang.

18 recordsLinked to original sources
PubMed1995

Menkes' kinky-hair disease: radiologic findings in a patient treated with copper histidinate.

A patient with Menkes' kinky-hair disease was treated from an early age with copper histidinate. This patient did not display the progressive mental deterioration and early death typical of patients with Menkes' disease; on the contrary, his intellectual capabilities were above average for his age. The magnetic resonance imaging findings were unique, showing some tortuosity and elongation of the arteries but no evidence of cerebral atrophy, demyelination or subdural hygromas.

Brain↗
PubMed1993

Fahr's disease associated with astrocytic proliferation and astrocytoma.

This report documents the neuropathological findings of astrocytic proliferation and astrocytoma in a patient with Fahr's disease. At autopsy, there was extensive bilateral symmetrical calcification involving basal ganglia, sulcal depth of the cerebral cortex, and dentate nuclei of the cerebellum. A large low-grade astrocytoma was identified in the left parietal lobe. Astrocytic proliferation was also noted in the areas of early calcification and at the margins of large calcareous deposits, away from the tumor.

Adult↗
PubMed1992

Lumbar facet joint asymmetry. Intervertebral disc herniation.

A study of 136 patients with lumbar intervertebral disc herniation was undertaken to test the hypothesis that asymmetry of the facet joints is associated with the level, type, and side of herniation. Fifty cases of central herniation and 86 cases of lateral herniation, all at the L4-5 or L5-S1 levels, were studied by computed tomographic scans. Adjacent (nonherniated) levels were used as controls. The facet joint angles were measured at the L4-5 and L5-S1 levels of the control, central, and lateral herniated levels. The results showed a similar degree of facet joint asymmetry at all levels. In cases of lateral herniation, there was a significant difference in the facet angle between the herniated and nonherniated side at the L5-S1 level, but not the L4-5 level. The mean difference, however, was less than 3 degrees and not considered to be clinically relevant. There was no difference in the distribution of the more coronally or sagittally facing facet joints with respect to the side of lateral herniation. These results do not support the hypothesis that facet asymmetry is associated with lumbar intervertebral disc herniation.

Adult↗
PubMed1982

Lumbar spinal nerve lateral entrapment.

In past years, lumbar nerve lateral entrapment seldom has been diagnosed. A presumptive preoperative diagnosis has been made based on clinical findings and radiographs demonstrating disc resorption. The Computed Tomography scan has made it possible to diagnose the lesion with certainty and accuracy. Treatment for patients who do not respond to conservative measures is a bilateral minimal partial laminectomy. The lateral canal is enlarged by removing the medial and anterior parts of the superior articular process. Adhesion formation is prevented by placing a free fat graft posterior to the dura. Instability is diagnosed by examining stress radiographs and, when present, is treated by a one level posterolateral fusion. After operation, marked improvement was obtained in 62% of patients and slight improvement in another 21%; 17% were unimproved. Sixty-two per cent of patients reported no pain or mild pain. Sixty-six per cent resumed their previous occupation.

Adult↗
PubMed1977

Computed tomography in intracranial arteriovenous malformations.

22 patients with proved intracranial arteriovenous malformations (AVM) were studied by computed tomography (CT). Of these, 18 were also studied by CT after intravenous injection of contrast material. The plain scan was normal in 23% of cases. A combination of plain and contrast-enhancement CT proved to be superior to other screening techniques in patients with a possible intracranial AVM.

Humans↗
PubMed1977

Computed tomography in the evaluation of intracranial aneurysms and subarachnoid hemorrhage.

Computed tomography (CT) is a reliable technique for examining patients with subarachnoid hemorrhage and intracranial aneurysms. Extravasated blood is easily recognized and the location of the ruptured aneurysm may frequently be predicted by its distribution into the subarachnoid spaces and brain parenchyma. CT alleviates the need for repeat angiography while following the patient's clinical evolution since it clearly shows rebleed, edema follwoing vasospasm, and hydrocephalus.

Female↗
PubMed1977

Computerized tomography as a possible aid to histological grading of supratentorial gliomas.

Computerized tomography (CT) is known to be very helpful in demostrating the presence and extent of supratentorial gliomas, practically in combination with intravenous injection of contrast material. Certain specific density patterns were found to exist and enabled us to differentiate with confidence the low-grade gliomas from the glioblastomas. Overlapping did occur, however, as was to be expected, since histological proof was sometimes obtained by the needle biopsy with its inherent doubt as to true tumor representation. Future CT techniques such as sequential scanning after intravenous injection of contrast material may further increase the usefulness of CT scans in the diagnosis and therapeutic approach to the patient with a suspected glioma.

Brain↗