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S Teich-Alasia

Publications and source records attributed to S Teich-Alasia.

At least 19 recordsLinked to original sources
PubMed1999

Expression and role of IL-15 in post-burn hypertrophic scars.

Hypertrophic scarring is a skin disorder that occurs after wounding and thermal injury. There is accumulating evidence that immunologic processes such as infiltration of activated T lymphocytes and altered cytokine production may play a role in the formation of hypertrophic scars. Interleukin-15, a cytokine identified as a T cell growth factor, also acts as a chemoattractant for T cells and has pro-inflammatory properties. We investigated the expression and the role of this cytokine in hypertrophic scarring. IL-15 expression was compared in skin biopsies of hypertrophic scars (HS) both in active (AHS) and in remission (RHS) phases, in normotrophic scars (NTS) and in normal skin using reverse transcriptase-polymerase chain reaction and immunohistochemistry. IL-15 expression in HS was significantly higher than in NTS or normal skin. Furthermore, AHS expressed higher levels of IL-15 than RHS. Immunohistologic analysis of AHS samples showed strong IL-15 immunoreactivity in keratinocytes and Langerhans cells in the epidermis and in macrophages, fibroblasts, and dermal dendritic cells in the dermis. High levels of IL-15 expression in AHS correlated with abundant infiltration of activated CD3+ cells. Ex vivo experiments indicate that IL-15 can sustain the proliferative response of T cells derived from AHS but not from RHS and NTS. In addition, IL-15 prevents both cytokine deprivation and activation-induced apoptosis of T cells derived from AHS. Taken together, these results suggest that IL-15 can be involved in the recruitment, proliferation, and apoptosis inhibition of T cells in AHS. The findings that the evolution from an AHS to a RHS is associated with a decrease in IL15 expression, and with a loss of IL-15 responsiveness in ex vivo-cultured T cells, indicate that this cytokine plays an important role in the biology of pathologic scar formation.

Adolescent↗
PubMed1994

Sensory endings in skin grafts and scars after extensive burns.

Fifteen patients who underwent a split thickness skin graft operation for full thickness burns and six patients with postburn scars were biopsied after a standard aesthesiological examination completed with Weber and Dellon tests. A semiquantitative evaluation was performed on immunohistochemically stained sections to determine the presence or absence of PGP 9.5 immunoreactive intraepithelial fibres, complex sensory receptors, nerve fibres in the dermal papillae, vessel-innervating fibres, gland-innervating fibres, and nerve trunks in the deep dermis. The reinnervation pattern was similar in grafts and scars. With regard to sensory receptors, free nerve endings and Merkel-neurite complexes were observed. Statistical analysis suggested a significant correlation between sensibility and the amount of regenerated nerve structures (particularly in the epidermis and dermal papillae).

Analysis of Variance↗
PubMed1992

Morphology of corpuscular receptors in hairy and nonhairy human skin as visualized by an antiserum to protein gene product 9.5 compared to anti-neuron-specific enolase and anti-S-100 protein.

The present study elucidates the morphology of encapsulated receptors in human skin by means of immunohistochemistry for the recently characterized neurospecific marker protein gene product 9.5, in comparison with neuronal specific enolase and S-100 protein. Only two types of corpuscles are identified, Meissner's corpuscles and simple coiled corpuscles. Moreover, this investigation reveals that though regional specialization may exist with regard to the encapsulated receptor density, the comparison of hairy and nonhairy skin does not reveal important differences.

Biomarkers↗
PubMed1986

A subscapular-pubic fascio-cutaneous flap for reconstruction of the chest wall following excision to the extent of near inoperability.

The use of an extensive fascio-cutaneous flap with skin from the thorax and abdomen, starting from the lateral and subscapular area behind the posterior axillary line and going down to the homolateral pubic and inguinal area, is described. This type of flap is used for repair of very extensive skin loss on the thorax when free grafts, the only alternative, are unsuitable because of the need for more effective and definite covering.

Breast Neoplasms↗
PubMed1983

[Functional and morphological study of the resensitization of transplanted skin flaps].

A study was conducted to assess sensory function in skin grafts, its effectiveness being an essential condition for ensuring coverage of loss of substance and total functional recovery of the transplanted skin. Morphological and structural criteria to identify cutaneous sensory receptors were established, and data related to their functional activity obtained following an exhaustive literature review. Clinical studies from 1960, employing conventional tests of responses to stimuli, have demonstrated that sensory recovery in transplanted flaps is strictly proportional to that which existed previously. More recent studies have involved equipment to apply stimuli and record responses providing objective assessment of tactile, pain, and thermal sensitivities. Histologic examinations were also performed to try to obtain morphological confirmation o results from the exposed clinical methods. Analysis of a selection of clinical cases studied has demonstrated that more marked recovery of sensory function in transplanted flaps is related to histological evidence of a greater density of regenerated nerve endings.

Humans↗
PubMed1979

Considerations on early surgery in the treatment of extensive burns.

The results obtained with early surgical treatment of burns have been re-examined from various aspects. Early escharectomy, which tranforms the necrobiotic tissue into a surgical lesion, reduces the chemical factors of inflammation, lowers the lactic acid level and depresses the activity and disordered proliferation of the fibroblasts and the consequent laying down of immature collagen which is responsible for the pathological evolution of the burn scar. The removal of toxic material with proteasic activity, the reduction in the risk of sepsis, the saving of work for the immunopoietic mechanism, a reduction in the weight loss through improved nitrogen balance and an increase in the anabolic phase of muscular metabolism by early movement as well as a shortening of the period of hospitalization--all are factors in favour of the early surgical technique. Better healing is obtained by the elimination of the necrotic tissue, a reduction in the haematologic tissue inflammation mediators, an increase in the antibacterial defence following the reconstruction of the skin surface with covering materials and the rapid articular reduction; not to mention the inhibition of the formation of granulation tissue.

Burns↗