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S Teitel

Publications and source records attributed to S Teitel.

At least 37 records · Page 2Linked to original sources
PubMed1977

A structure-activity analysis of the preferred conformation of the benzyl substituent of tetrahydropapaveroline at the beta receptor.

The effect of restricting the motion of the 3,4-dihydroxybenzyl substituent of tetrahydropapaveroline (THI) on its ability to stimulate the beta adenylate cyclase of the rat erythrocyte was investigated. A number of protoberberines and aporphines were tested as models of two classes of compounds where the benzyl substituent is rigidly but differently fixed. Unexpectedly, the beta agonist activity was associated with both structural types. This could be explained by the assumption that a phenylalanyl or tyrosyl residue of the receptor protein is free to rotate and bind with either position of the benzyl moiety as fixed in the protoberberine and aporphine structures.

Adenylyl Cyclases↗