Biomedical subjects

S Tenneson

Publications and source records attributed to S Tenneson.

3 recordsLinked to original sources

PubMed1985

CSF sulfoconjugated catecholamines in man: their relationship with plasma catecholamines.

Simultaneous plasma and cerebrospinal free and sulfoconjugated norepinephrine, epinephrine, dopamine and homovanillic acid determinations in 38 patients with various neurological disorders have shown consistently lower concentrations of dopamine sulfate, norepinephrine sulfate, and epinephrine sulfate in the cerebrospinal fluid than in plasma. An approximately three fold increase of plasma dopamine sulfate concentrations following banana ingestion did not result in increased dopamine sulfate concentrations in cerebrospinal fluid. There were positive correlations between plasma and cerebrospinal fluid concentrations of free norepinephrine and epinephrine as well as norepinephrine sulfate, dopamine sulfate and free homovanillic acid. Cerebrospinal fluid and plasma are apparently separated by the blood-brain barrier impermeable to catecholamine sulfates from the blood. Some other data and the observed positive correlation between cerebrospinal fluid and plasma dopamine and norepinephrine sulfates suggests however that catecholamine sulfates may pass from cerebrospinal fluid to the blood and reflect events in the brain.

Adolescent↗

PubMed1985

Peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats.

We have studied several parameters of peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats during the development of hypertension. Compared to Wistar-Kyoto rats, there was an increased dopamine content in 8-week-old spontaneously hypertensive rats in the adrenals (1.6 +/- 0.1 vs. 1.2 +/- 0.1 nmol/pair in Wistar-Kyoto rats) and kidneys (97 +/- 12 vs. 63 +/- 7 pmol/g tissue in Wistar-Kyoto rats), but the dopamine content in peripheral organs from normotensive 4-week-old spontaneously hypertensive rats did not differ from Wistar-Kyoto rats. In the heart, the dopamine increase was observed in 14-week-old spontaneously hypertensive rats (systolic blood pressure: spontaneously hypertensive rats, 189 +/- 9; Wistar-Kyoto rats, 106 +/- 2 mm Hg;) in both atrium (spontaneously hypertensive rats, 133 +/- 14; Wistar-Kyoto rats, 86 +/- 20 pmol/g tissue) and ventricle (spontaneously hypertensive rats, 41 +/- 6; Wistar-Kyoto rats, 23 +/- 5 pmol/g tissue). Urinary free dopamine and dihydroxyphenylacetic acid, but not norepinephrine or normetanephrine, in spontaneously hypertensive rats significantly increased between the ages of 7 and 11 weeks, reflecting the dopamine changes in tissue and suggesting a selective increase of the rate of dopamine synthesis and release.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Glands↗

PubMed1984

The adrenal synthesis and tissue content of dopamine increase when the blood pressure rises in spontaneously hypertensive rats.

Hypertensive (eight-week-old) but not normotensive (four-week-old) spontaneously hypertensive rats (SHR) have a higher adrenal dopamine (DA) synthesis and release, DA concentration in adrenals and kidney and urinary excretion of DA, dihydroxyphenylacetic acid and methoxytyramine than control WKY rats. At age 14 weeks, with progressive hypertension, the heart atria and ventricle DA content also increases. These abnormalities remain unaccompanied by changes in norepinephrine and epinephrine. Increased DA release, tissue content and urinary excretion of DA and its metabolites are thus selectively involved in the sequence of events leading to hypertension in SHR.

Adrenal Glands↗