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Biomedical subjects

S Theodorini

Publications and source records attributed to S Theodorini.

At least 19 recordsLinked to original sources
PubMed1975

Familial clustering of degenerative cardiovascular diseases.

In two geographical areas; the Gurghiu Valley, in a mountain region, and the village of Jurilovca on the shores of the Razelm lagoon, investigations were performed in 390 subjects of both sexes over 20 years of age, first degree relatives of healthy index subjects (males aged 40 to 60 years) and 298 subjects of both sexes over the of 20, first degree relatives of index-subjects with coronary heart disease and/or hypertension. The prevalence of these diseases was found to be 40% higher in the families of diseased subjects. The authors assume the participation of a genetic factor in the etiology of these two degenerative cardiovascular diseases.

Adult↗
PubMed1975

Coronary heart disease and risk factors in some special type collectivities.

Transversal epidemiologic investigations carried out in different populations from several regions of Romania : Gurghiu Valley (lumberjacks from a mountain region), Danube Delta and Razelm lagoon complex (fishermen), and Bucharest have shown that, in spite of the high caloric value of food and even of a high intake of saturated fats, mean serum cholesterol is lower in the rural areas than in Bucharest, probably owing to the strenuous physical work. However, except myocardial infarction, more frequent in the urban than in the rural regions, the other forms of coronary heart disease have a relatively higher frequency in villages, particularly atrial fibrillation and ECG signs of ischemia. These findings might be explained by a greater prevalence of hypertension in these populations. It is concluded that the risk factors, which act synergically, depend on the complex structure of the "ecologic niche".

Adult↗
PubMedDate not supplied

Evolution of ischemic heart disease risk factors in "The Bucharest Multifactorial Preventive Trial of Coronary Heart Disease" after 15-year follow-up.

The paper presents the evolution of the levels of smoking, hypercholesterolemia, essential hypertension and obesity in the course of a prophylactic action carried out for 15 years (1971-1986) in a group of 5000 males aged 40-60 years. In the group still available after 15 years of follow up consisting of 2000 subjects, a decrease was obtained in the number of smokers, from 22.3% to 5.6% of hypercholesterolemia from 31.3% to 23.7%. The cumulated incidence of essential hypertension has increased from 15.5% to 36.7% and of obesity from 12.6% to 14.4%. At the same time the incidence of angina pectoris and myocardial infarction increased from 1.1% to 5.3%. For comparison are presented data obtained in a similar control group.

Adult↗
PubMedDate not supplied

A longitudinal study, for 15 years, of the myocardial infarction, in a population of middle aged men.

The long-term evolution of the patients with incident myocardial infarction (MI) was studied in a group of 5,000 men ranging in age from 40 to 60 years, included in an action of primary prevention of arterial hypertension (AHT) and coronary heart disease, in comparison with a second group of 5,000 other men with similar age and occupation, selected at random, who received medical assistance without primary prevention. The incidence of MI was of 2.34% (111 cases) in the group of intervention, with a cardiovascular mortality of 46.84%, while in the control group it amounted to 2.88%, with an overall mortality by cardiovascular diseases of 52.7%. The highest mortality rate was recorded in the patients with recurrent infarctions (72.6% and 60% of deaths, respectively). During a follow-up period of 15 years, the presence of AHT before the occurrence of MI proved to be an aggravation factor for the cardiovascular mortality which, in the group of intervention, was two times more frequent in such patients than in those with pre-existent angina. The pathologic association angina--AHT as well as the AHT alone, preceding the MI occurrence, have significantly increased the risk of cardiovascular mortality. The action of primary prevention has evidently reduced the immediate mortality, as well as that of the patients with angina before the MI.

Coronary Disease↗
PubMedDate not supplied

The predictive value of some major ECG changes.

Out of a group of 5,000 men included in an action of primary prevention of coronary heart disease and arterial hypertension, started in 1971 in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest, the authors have selected the subjects presenting major ST--T changes and conduction troubles. The predictive value of some ST--T changes for the subsequent occurrence of major coronary accidents was also investigated in 3,000 male subjects of similar age and occupation, also selected at random, but who were not included in the action of primary prevention of the risk factors. The results obtained demonstrated the value of such an early intervention upon the risk factors of coronary heart disease, the incidence of coronary accidents (myocardial infarction, sudden death) being smaller in the group of intervention than in the control one.

Adult↗
PubMedDate not supplied

The Bucharest Multifactorial Prevention Trial of Coronary Heart Disease--ten year follow-up: 1971-1982.

The trial begun in 1971 and the paper brings the results after a ten-year follow-up. Both the intervention and control group contained 5000 men with a similar socioeconomic and professional structure; the intervention group was examined every six months in the first 5 years and annually in the second phase. The control group was examined "only after" 5 years and a second time at the final moment. The decreases of the cumulative ten-year incidences were: for hard events--26.7%; for myocardial infarction--20%; for fatal myocardial infarction--52%; for stroke--31%; for cardiovascular mortality--38%; for total mortality--14%. The trend of serum cholesterol and cigarettes/day was downward, but the blood pressure had a rather flat evolution in the intervention group. The control group disclosed also some downward trends.

Adult↗
PubMedDate not supplied

The Bucharest multifactorial prevention trial of coronary heart disease. General methodology and risk factor correction after five year follow-up (1971-1977).

Both the intervention and the control group included each 5000 men aged 40-60 years, randomly selected by their home address in five districts of the city of Bucharest. The intervention group underwent an "at entry" examination for risk factor detection (high serum cholesterol, high blood pressure, overweight, diabetes, minor ECG abnormalities, family history) and subsequently a five-year multifactorial intervention aimed to reduce the risk factors. Both groups were followed up in this lapse of time for major end-points: myocardial infarction, stroke, sudden death. The qualitative analysis of the results used ten evolution indices based on a quantal counting and lead to a classification of risk factors which allowed the setting up of a strategy for their correction. The quantitative analysis showed the following decreases between the first and the last examination in the intervention group: for serum cholesterol greater than or equal to 250 mg/dl -17%; for cigarettes/day greater than or equal to 15-53%; for overweight greater than or equal to 30% - 13.57%; for high blood pressure -8%; for the overall risk computed by multiple regression -33.8%.

Adult↗
PubMedDate not supplied

The Bucharest multifactorial prevention trial. The changes of morbidity and of general and specific mortality.

The paper presents the results of the Bucharest multifactorial prevention trial of coronary heart disease, concerning changes in cardiovascular morbidity and mortality during the first 5-year-period of follow-up. The age adjusted 5-year-rates disclose important reductions in the intervention group in comparison with the control one: for hard events (myocardial infarction, stroke, acute coronary insufficiency)--by 41%; for myocardial infarction--by 35%; for coronary mortality--by 38%; for stroke--by 39%; for cardiovascular mortality--by 30%. The decrease of hard events, myocardial infarction and stroke incidences are statistical significant. The evolution curves of cardiovascular morbidity and mortality show that both groups (the intervention as well as the control one) began with near the same values, but on the way and especially after 5 years they are differently located, those of the control group being higher than those of the intervention group.

Adult↗