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S Thorp

Publications and source records attributed to S Thorp.

5 recordsLinked to original sources

Prehospital use of paracetamol among children attending the accident and emergency department.

OBJECTIVES: To identify patterns of prehospital administration of paracetamol to children who were perceived to be feverish by their carers. METHODS: A prospective cohort study of carers of children attending a paediatric accident and emergency (A&E) department. Carers of children completed a questionnaire to identify domestic patterns of paracetamol use. Data were collected on temperature of the child in the A&E department, administration of antipyretics in the A&E department, diagnosis, and disposal from the A&E department. RESULTS: Seventy five adults attending the A&E department consented to involvement. Sixty five of the children were feverish on arrival in the A&E department. Twenty one children (32.3%) had not received paracetamol before attending. There was a significant relation between knowledge of the antipyretic properties of paracetamol and administration (chi(2)=5.0, p<0.05). There was a significant correlation between fever and administration of paracetamol in the A&E department (chi(2)=23.7, p<0.01), however, 15 feverish patients (24.6%) were not treated. CONCLUSIONS: Most carers administer paracetamol appropriately in the prehospital setting. Administration correlates significantly with knowledge of its benefits. There is scope for education of carers and A&E department staff in the in the appropriate use of antipyretics such as paracetamol.

Acetaminophen↗

Factors affecting the exchange of tocopherol between red blood cells and plasma.

The purpose of this study was to clarify factors that affect the equilibrium distribution of alpha-tocopherol between red blood cells and plasma. Plasma labeled with 14C-alpha-tocopherol was incubated with red cells for 4 to 6 hr and the distribution of the tocopherol determined in the two compartments (red blood cell (RBC: plasma ratio). Use of heparin as anticoagulant gave a higher RBC: plasma ratio than acid citrate dextrose. The RBC:plasma ratio was affected by the hematocrit of the incubation mixture, higher ratios being obtained with lower hematocrits. The ratio was not related to the plasma concentration of alpha-toxopherol, indicating that the red cell was not saturated up to four times normal plasma levels. Of possible clinical significance was the finding that the RBC: plasma ratio was related to the total lipid concentration of plasma. Red cell content of alpha-tocopherol decreased as plasma lipids increased, until at three times normal plasma lipid concentration the red cells had one-third or less of their normal concentration of alpha-tocopherol. The implications of this observation on the relationship between plasma and tissue aplha-tocopherol are discussed.

Animals↗