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S Thunold

Publications and source records attributed to S Thunold.

At least 19 recordsLinked to original sources
PubMed1992

Koilocytosis in neoplasia of the urinary bladder.

Koilocytosis is commonly regarded as indicative of human papilloma virus infection in the uterine cervix. In 1987 morphologically similar changes were reported in bladder tumours. This is confirmed in the present study, the incidence here being 65%. In addition the incidence of koilocytic change was shown here to increase from non-infiltrative WHO grade I to infiltrative WHO II lesions, and to be more common in bladder lesions in women with cervical koilocytosis. The latter is in keeping with our previous report that the incidence of koilocytosis in the cervix of patients with bladder neoplasia is higher than expected in the general population, adding support to the hypothesis that both lesions may be virus-related.

Adult↗
PubMed1991

Risk of cervical intraepithelial neoplasia in women with glomerulonephritis.

OBJECTIVE: To investigate the occurrence of cervical intraepithelial neoplasia in women with glomerulonephritis and its possible association with immunosuppressive treatment. DESIGN: Retrospective study of cytological or histological specimens from women presenting with glomerulonephritis and a group of case and age matched controls. SETTING: University department of pathology, Norway. PATIENTS: 81 women presenting with glomerulonephritis from 1981 to 1988, from whom gynaecological cytological or histological specimens were available. A group of 162 case and age matched controls. MAIN OUTCOME MEASURES: Age when glomerulonephritis of cervical intraepithelial neoplasia was diagnosed, type and characteristics of kidney lesion, stage of cervical intraepithelial neoplasia and presence of human papillomavirus, use of immunosuppressive treatment. RESULTS: Cervical intraepithelial neoplasia was more common in women with glomerulonephritis than in their controls (16/81 (20%) v 7/162 (4%), p less than 0.001) and was more advanced in those with glomerulonephritis than in the controls (9/81 (11%) of the study group had grade III cervical intraepithelial neoplasia compared with 1/162 (1%) of the controls). The increased occurrence of cervical lesions was independent of the use of immunosuppressive treatment, but the individual lesions tended to be more advanced when it was used (four of the seven cervical lesions in women with glomerulonephritis who had received immunosuppressive treatment were carcinoma in situ). Of the nine cervical lesions tested, seven were virus associated. CONCLUSION: Women with glomerulonephritis should have regular cervical smears, irrespective of their use of immunosuppressive treatment.

Adult↗
PubMed1991

IgG Fc receptors on epithelial cells of distal tubuli and on endothelial cells in human kidney.

IgG Fc receptors (FcR) in cryostat sections of human kidney were studied using functional assays and monoclonal antibodies (MoAbs). Using functional assays, FcR were detected on cells in glomeruli and distal convoluted tubuli, on endothelial cells and on interstitial cells. These cells were also stained with B1D6, a MoAb reactive with a 40-kD molecule with low affinity FcR activity. Using MoAbs against leukocyte FcR, a different pattern of reactivity was obtained. MoAbs against FcR I (32.2), FcR II (IV.3 and C1KM5) and FcR III (3G8 and Leu11b) stained interstitial macrophages only. The data confirm the presence of FcR on renal glomeruli and interstitial cells and also indicate that epithelial cells of distal tubuli and endothelial cells express FcR. Furthermore, renal FcR appear to be structurally different from the FcR I, II and III defined on leukocytes.

Antibodies, Monoclonal↗
PubMed1990

[Heart disease in myasthenia gravis].

The symptoms in myasthenia gravis are mainly due to reduced function of skeletal muscle. But some patients, especially those with a thymoma, have symptoms or signs of myasthenia-related heart disease. Some of our patients with histological myocarditis have died suddenly and unexpectedly. The frequency of electrocardiographic abnormalities among myasthenic patients has increased. Patients with myasthenia gravis should be subjected to cardiac monitoring after thymic surgery and during myasthenic crisis and other severe illnesses. If clinical examination leads to suspicion of myocarditis, the patient should receive immunosuppressive therapy.

Adult↗
PubMed1990

Successful pregnancy following treatment of primary malignant lymphoma of the uterine cervix.

A case of primary histiocytic lymphoma in the uterine cervix of a 22-year-old nulligravid woman is reported. To avoid surgical or radiological castration she received six courses of combination chemotherapy (cyclophosphamide 750 mg/m2, doxorubicin 50 mg/m2, vincristine 2 mg all iv on Day 1 and then together with oral prednisone 50 mg twice daily on Days 1-5). Approximately 20 months after therapy she delivered a healthy child. Six years have passed since primary treatment was initiated. No evidence of recurrent lymphoma has been observed.

Adult↗
PubMed1989

Endodermal sinus tumor treated with high dose cisplatin.

A woman with an endodermal sinus tumor of the ovary stage IV obtained a short but complete remission after treatment with vinblastine, bleomycin and standard dose cisplatin. A second complete remission for 42+ months was obtained with a regimen of vinblastine, bleomycin, etoposide, and high dose cisplatin. This result suggests a dose-response relationship for cisplatin in ovarian germ cell tumors.

Adult↗
PubMed1986

Thymic lymphoepitheliomas and skeletal muscle expressing common antigen(s).

Rabbit antiserum to a citric acid extract of human skeletal muscle (CA) stained epithelial thymoma cells as well as skeletal muscle. Thymomas from two myasthenia gravis (MG) patients showing no circulating anti-CA antibodies prior to thymectomy were also stained by the antiserum. Thus, in these patients as well, the thymoma and skeletal muscle possess common antigens. The rabbit and the human antibodies most probably reacted with different antigens, apparently located close to each other in the cell membrane. The reason why anti-CA antibodies cannot be detected in serum from a few MG patients with a thymoma may be that the thymoma-associated antigen is not present in vivo in these cases, or that an inhibiting factor blocks the antibody synthesis. Both patients developed anti-CA antibodies post-operatively, which favours the latter explanation.

Absorption↗
PubMed1982

The localization of glomerular C3b receptor by immunoelectron microscopy.

By an indirect immunoperoxidase technique, rabbit antiserum to solubilized C3b receptor stained the glomeruli in cryostat sections of human kidney. The staining was localized to the glomerular basement membrane zone. Glomeruli in sections of aldehyde-fixed paraffin-embedded tissue did not stain. However, if the sections were pretreated with proteolytic enzymes, the glomeruli were stained by the antiserum as in the cryostat sections. Electron microscopy revealed that the reaction product was located in the cell membrane of the epithelial cells. In some cells the reaction product was also found in vacuoles in the cytoplasm. The basement membrane and endothelial and mesangial cells did not stain.

Basement Membrane↗
PubMed1979

Lymphocyte subpopulations in thymus and blood from patients with myasthenia gravis.

Cell suspensions were prepared from hyperplastic thymic tissue and lymphoepithelioma from patients with myasthenia gravis and from presumed normal thymic tissue obtained at cardiac surgery. The mononuclear cells were examined for surface markers. The mean percentages of both T lymphocytes and Fc receptor-carrying lymphocytes were similar in the three groups, whereas there was an increase in C receptor-carrying lymphocytes in the samples from myasthenic patients. Sections from the thymus gland were examined for T and B markers. In the hyperplastic thymus and in lymphoepithelioma, the T lymphocytes were distributed diffusely throughout the cortex and the medulla; in the normal thymus they were predominant in the cortex. The mean percentage of T and B lymphocytes in peripheral blood from patients with myasthenia gravis was normal. Thymectomy involved a transitory decrease in T lymphocytes with a corresponding increase in B lymphocytes.

B-Lymphocytes↗
PubMed1978

Oral lesions of epidermolysis bullosa acquisita.

Oral lesions with histologic evidence of subepidermal bullae are described in a patient with epidermolysis bullosa acquisita (EBA). Deposition of IgA, IgG, and C3 in the basement membrane zone and vasculitis with C3 deposits in vessel walls suggest the possible role of immune complexes in the pathogenesis of the disease.

Adult↗
PubMed1978

Complement receptors in pathological human renal glomeruli.

Glomerular complement receptors (GCR) were demonstrated by the adsorption of C3 coated sheep erythrocytes to cryostat sections of human kidneys. An epithelial localization of the GCR is implied by the binding pattern of the indicator cells. The GCR activity was reduced in all glomeruli where in vivo deposition of immunoglobulin and C3 along the capillary wall was observed. In fourteen out of nineteen biopsies where deposits in the mesangium were seen, reduced GCR activity was also observed, whereas GCR activity was normal in the other five. Immunofluorescence and haemadsorption tests performed on the same section showed that C3 deposits corresponded to areas showing reduced complement receptor activity. Areas outside the C3 deposits adsorbed indicator cells coated with various amounts of C3 similarly to the adsorption to glomeruli seen in normal adult and fetal kidneys. Sclerotic glomeruli showed no GCR activity. The results indicate that the complement receptors play a role for the binding of complement-containing complexes in glomeruli.

Binding Sites, Antibody↗
PubMed1978

Thyroiditis in myasthenia gravis.

Three out of 40 patients with myasthenia gravis had chronic thyroiditis. The thyroid disease preceded the neuromuscular disorder in two patients, while the third developed a slowly progessive hypothyreosis during the course of the myasthenia. One patient had an initial thyrotoxicosis with subsequent development of hypothyreosis. Of the remaining 37 patients, two had enlarged thyroid glands, positive family history of thyroid disease and antibodies to thyroid globulin, but were euthyreot.

Adult↗
PubMed1978

Epidermolysis bullosa acquisita and Crohn's disease.

A patient with epidermolysis bullosa acquisita (EBA) associated with Crohn's disease is presented. The clinical, histological and immunological findings were in keeping with previous reports. However, clinically normal skin and mucosa exhibited deposits of IgG and C3 in the basement-membrane zone. These deposits remained unchanged during the treatment period. It is therefore suggested that immunological mechanisms are implicated in pathogenesis of the disease.

Adult↗