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Biomedical subjects

S Thurlow

Publications and source records attributed to S Thurlow.

10 recordsLinked to original sources
PubMed1992

Success rates for rehabilitation of vascular amputees: implications for preoperative assessment and amputation level.

All lower limb amputations performed during 1986 and 1988 in eight hospitals in the south-east region were assessed. Of 440 amputations for vascular disease, 193 were above-knee, 193 below-knee, 15 Gritti-Stokes, 15 through-knee and 24 bilateral. Of the 440 patients, 75 died in hospital, 113 were considered unsuitable for a prosthesis and 252 (57 per cent) were referred for prostheses. Rehabilitation questionnaires were sent to 179 patients (41 per cent), as a further 54 had died and 19 had become known non-wearers before the study commenced. The response rate was 81 per cent; 102 patients completed the questionnaire, 21 were reported dead, and 22 were non-wearers. Of a maximum rehabilitation score of 12, 52 patients scored 6 or more (consistent with mobility on their artificial limb around the home), and 21 scored 9 or more (a standard accepted as successful rehabilitation). It is concluded that 10-15 per cent of amputees achieve mobility around the home on their prosthesis. Only 5 per cent, however, rehabilitate well and become independent of their wheelchair. When amputation is inevitable, more consideration should be given to surgery that optimizes wheelchair rehabilitation.

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PubMed1982

Effects of prenatal exposure of mice to "low-dose" diethylstilbestrol and the development of adenomyosis associated with evidence of hyperprolactinemia.

The developing genital tract of the fetal mouse was exposed to diethylstilbestrol (DES) and the induction of noncyclic ovarian function in adult life was circumvented. Female mice of two inbred strains, BALB/c and C3H, were mated with BALB/c male mice and on the seventh day of pregnancy were fed a diet containing 0.2 micrograms of DES/gm continuously until the morning after delivery of the young. This regimen did not interfere appreciably with continuance of pregnancy, and offspring of normal body weight were delivered. When the mice reached maturity, the fertility and fecundity of the cycling exposed female mice were, however, reduced significantly. Virgin exposed BALB/c female mice, observed until 18 months of age, developed neoplasms with the same low frequency normally encountered in this strain, while the exposed hybrids developed mammary carcinomas almost twice as often as did an unexposed population. In addition, two benign lesions of the genital tract occurred frequently in the exposed hybrid female mice. The most extensive of these resembled adenomyosis as seen in the female human in that foci of nonneoplastic endometrium penetrated the muscular layers of the uterus, often forming small, fluid-filled blebs evaginating the serosal surface. This lesion was reproduced by grafting day-old female mice with a single ectopic hypophysis, indicating that chronic hyperprolactinemia was a major endocrine factor in its genesis. The second was an enlargement of the cervix with extensive mucoid alterations within the muscularis, a lesion that could be produced by the continuous estrogenization of adult animals. Both lesions occurred to a much lesser extent in BALB/c female mice, and neither was felt to contribute to the reduced fecundity noted in DES-exposed female mice.

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