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S Tigaud

Publications and source records attributed to S Tigaud.

27 records · Page 2Linked to original sources
PubMed1986

[Evaluation of the use of ofloxacin in the treatment of various infections].

We investigated the clinical efficiency and safety of ofloxacin, a new fluoroquinolone, for the treatment of various documented bacterial infections in 26 patients (10 females, 16 males) aged 17 to 84 years. Ofloxacin monotherapy was given orally in a dose of 200 mg twice (25) or three times (1) a day. Antibiotic levels and serum bactericidal activity were measured using a microbiological method on the second and sixth days, before and 2 and 6 hours after a single dose. The infectious episode treated was enterocolitis in 7 cases (5 Shigella, 2 Salmonella), Salmonella septicemia in 9 (7 typhoid fevers and 2 Salmonella minor infections), chronic osteoarthritis in 3 (1 E. coli, 2 S. aureus + P. aeruginosa), a soft tissue infection in 3 (2 S. aureus, 1 E. coli), acute pleuropneumonia in 2 (2 Klebsiella pneumoniae), pyelonephritis with bacteremia in 1 (Klebsiella pneumoniae), and pneumococcal pneumonia with septicemia in 1. Mean duration of therapy was ten days for 23 patients (range 7 to 30 days). The three patients with osteoarthritis were treated for 35, 95 and 270 days respectively. 24 patients recovered free of sequelae or germ carriage. Treatment failed in 1 case of chronic osteitis (S. aureus + P. aeruginosa) and in 1 staphylococcal soft tissue infection. No adverse reactions were observed except a slight increase in transaminases in 3 patients. Peak and through serum ofloxacin levels were 3.70 micrograms/ml and 0.95 micrograms/ml respectively on the second day and 3.25 micrograms/ml and 0.80 microgram/ml respectively on the sixth day.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1986

[Hepatic diffusion of ceftriaxone].

We studied the intrahepatic diffusion of ceftriaxone, a new third generation, very potent cephalosporin with a long serum half-life. Sixteen patients had percutaneous liver biopsy for suspected liver disease or protracted fever of unknown origin. Serum samples and liver biopsy specimens were taken simultaneously. Serial determinations of ceftriaxone concentrations showed that the hepatic half-life was significantly shorter than the serum half-life. We suggest that ceftriaxone be used in higher or more closely spaced doses for the treatment of liver infections.

Adult↗
PubMed1985

Pefloxacin: evolution of in vitro activity during 18 months of use in an intensive care unit.

The MIC of pefloxacin against all the strains (3122) isolated in an intensive care unit during 18 months was studied. The MIC of pefloxacin was estimated by standard agar diffusion method in Mueller-Hinton agar. All the strains with a MIC lower than 2 mg/l were considered as sensitive, between 2 and 4 mg/l as "intermediary" and over 4 mg/l as resistant. Geometrical means of MICs were calculated for each month and for different species. The study continued for 18 months from the introduction of the drug which was in widespread and constant use as a first-choice antibiotic. No significant increase was detected in the incidence of resistant strains during the study; on the other hand, small, limited clusters of resistant strains were observed during minor nosocomial epidemics. The general features of quinolone activity, the spectrum of this new quinolone and the slow evolution of the bacterial population are discussed.

Bacteria, Aerobic↗
PubMed1985

[Study of the sensitivity of anaerobic bacteria using 2 dilution technics].

We studied forty-seven anaerobic strains recovered from blood cultures or pus from deep infections over three months. Antibiotic sensitivity was tested using two dilution techniques. For both, a standardized, controlled inoculum was used and strains with known susceptibilities were included. The first method consisted of dilution of antibiotics in Schaedler broth and MIC determination using microplates. In the second method, dilutions in Wilkins-Chalgren broth with 1.5 g/l agar and ATB-API plates were used; these plates are specially designed for anaerobes and have not yet been marketed. Advantages of dilution techniques for antibiotic sensitivity testing of anaerobes are recalled. Our findings establish that, under correct technical conditions, results of both methods studied are consistent.

Anti-Bacterial Agents↗
PubMed1982

[Sensitivity of 1041 strains of bacteria obtained from an intensive care unit with regard to aminoglycosides].

Antibiotic treatment of infections due to opportunistic organisms often involves an aminoglycoside/bêta lactamine combination. In order to help in the selection of the aminoglycoside used, a statistical study was made of 1041 strains of organisms obtained from an intensive care unit to 4 aminoglycosides: gentamicin, amikacin, tobramycin and dibekacin. These included Gram negative bacilli (enterobacteria, pseudomonas, acinetobacter) and staphylococci. The study showed amikacin to be the most suitable aminoglycoside for prescription in an infection threatening the vital prognosis in the short term and where the organism has not been identified. In non-threatening infections when the organism has not been identified, gentamicin, tobramycin or dibekacin should be used in preference to amikacin. For any type of infection, once the organism has been identified, amikacin should only be used if it is the only effective agent. When the organism is equally sensitive to gentamicin, tobramycin and dibekacin the choice of drug should take into account the known potential toxicities of each drug.

Amikacin↗