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Biomedical subjects

S Timonen

Publications and source records attributed to S Timonen.

At least 19 recordsLinked to original sources
PubMed1985

X chromatin, endomitoses, and mitotic abnormalities in human cervical cancer.

The incidence of X chromatin bodies and mitotic modifications and aberrations has been analyzed using Feulgen-squash preparations in 47 cervical cancers from Helsinki and 35 from Madison. Sixteen of the 82 tumors did not display any X chromatin bodies, and some others showed a lower than normal frequency, especially in the large nuclei. Different hypotheses to explain the absence of Barr bodies in female tumors have been reviewed. A new observation is that 44/82 tumors contained endomitoses. The metaphase/prophase ratio (M/P) was higher than 1.5 in all but three cases, reaching values as high as 23.0 (Madison) and 34.2 (Helsinki), and in one exceptional case, 51.8. The different types of cells, mitotic, endomitotic, and those with large to giant nuclei, form their own strands or layers. Cervical cancer is diagnosed earlier in Finland than in Madison due to a Pap mass screening program, and consequently, the survival of the patients after 5 years was 27/47 in Helsinki and 6/35 in Madison. No correlation could be established between the M/P (or other mitotic phenomena) or the stage and grade of the tumor, the age of the patient, or survival time.

Adult↗
PubMed1984

Mitotic modifications and aberrations in human cervical cancer.

Mitotic modifications and aberrations characteristic of human malignant tumors have been analyzed and illustrated in cervical cancer. Most of them can be explained by assuming that the coordination of the centrosomal and chromosomal mechanisms, typical of normal mitosis, is disturbed. When the spindle mechanism is ahead of the chromosomes, the prophase is relatively shortened. This expresses itself in an increase of the ratio of metaphases to prophases (M/P), which in normal tissues is around 1. With M/P values of 4-6, the first tripolar metaphases are formed, and with higher ratios, divisions having more and more poles appear. The spindle and the chromosomes are out of step in the opposite direction in endocycles, in which the spindle is slowed down or absent. The most common of the endocycles is endoreduplication, followed by endomitosis, which is found in more than half of the cervical cancers. Mitotic abnormalities include lagging chromosomes in metaphase and anaphase and bridges in anaphase, which, when numerous, may lead to restitution. More sporadically occurring are C-mitosis and other abnormalities, including cell and nuclear fusions. There is a wide range of variation in the occurrence and frequency of chromocenters within a tumor, and an even greater variation between tumors. About one-fifth of cervical cancers lack X chromatin bodies. The abnormal chromosome constitutions in cancer are the result of various mitotic modifications and aberrations, as well as chromosome rearrangements. New chromosome combinations are constantly created and selection promotes the fastest dividing ones, which, in turn, become new stem lines of the tumor.

Chromatin↗
PubMed1980

Management of vaginal agenesis.

Long-term results obtained through different methods of treatment were analysed in a series of 39 patients with congenital absence of the vagina. Thirty-three patients were treated with the McIndoe skin graft technique, 6 of them by the modification of Counseller and Davis. In three patients the neovagina was grafted with amnion and three were treated with the Frank nonoperative method. The result was graded good in 27 and satisfactory in 11 patients. In one patient the McIndoe operation resulted in a complete failure. There was no obvious difference between the results obtained by different methods except for the modification of Counseller and Davis which gave a good result in all cases. Judging from the general appearance and cytological pattern of the artificial vagina a more physiological result was achieved in patients with an amnion graft as compared with those with a skin graft. The nonoperative method is suggested as the first alternative in the treatment of patients with congenital absence of the vagina.

Adolescent↗
PubMed1977

Cervical cancer. Mass screening, incidence and mortality in Finland.

Since mass screenings were started in Finland, the incidence of cervical cancer has dropped by about 50 per cent. In the age groups 25-60 the decrease has been two thirds. Moreover, there has been a similar decrease in mortality in the younger age groups, in particular. All risk groups are not covered by the screening program, however. Cervical carcinoma is still a socio-medical and clinical problem particularly among elderly women.

Adult↗
PubMed1977

Results of treatment of carcioma of the cervix, 1964--1969. A report of 768 cases.

A series of 768 cases of primary invasive carcinoma of cervix was collected during the six years 1964--1969. This unselected material represents nearly one third of all new cases in Finland. The percentages of different stages (St) were: St I 49%, St. II 26%, St III 22% and St IV 3%. In comparison with earlier materials from our clinics an increase of St I was seen at the expense of St II. This probably results from increased use of the Papanicolau smear technique examinations. The incidence of St III and St IV was unchanged. Operative treatment combined usually with radiotherapy was used in 85% of the St I and in 38% of the St II cases. The remainder including those of St III--IV were treated by irradiation. The 5-year observed survival rates and relative survival rates (in brackets) were: St I 88% (92%), St II 51% (54%), St III 28% (31%), -t IV 0% and all stages together 63% (67%). A significant improvement in the 5-year results was found in the stages I and III when compared with the earlier material.

Adenocarcinoma↗