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Biomedical subjects

S Tonelli

Publications and source records attributed to S Tonelli.

10 recordsLinked to original sources
PubMed2000

Persistent polyclonal B lymphocytosis: morphological, immunological, cytogenetic and molecular analysis of an Italian case.

We describe a case of persistent polyclonal B-cell lymphocytosis (PPBL) studied by morphological, immunological, cytogenetic and molecular analysis. PPBL is a rare lymphoproliferative disorder with an unclear natural history. Although a few cases of malignancies are observed during PPBL, this disorder is usually considered to be an indolent syndrome. A longer follow-up in a larger number of patients is needed in order to clarify the natural history of PPBL and its potential to transform into a malignancy. As PPBL is a rare disease, establishing an international PPBL registry could be the most effective way to understand the natural history of this disease and to discover its etiologic factors.

Adult↗
PubMed1999

The role of interferon-alpha in the treatment of myeloproliferative disorders.

The interferons are cytokines with a wide array of biological properties. In hematological malignancies the most used IFN class is -alpha; it has been used for thirty years but the mode of action is still not absolutely clear. Nevertheless, the benefits of IFN-alpha for the treatment of CMD have been described in particular for CML and less for PV, ET and MMM. IFN-alpha is presently considered the golden standard of therapy for CML patients not eligible for SCT; the antileukemic effect has been well documented by hematological and cytogenetic response. The survival advantage for IFN treated patients is remarkable in comparison with patients treated with conventional chemotherapy. Recently, the combination IFN-alpha plus Ara-C has demonstrated to increase the rate of major cytogenetic response and to prolong survival. To date, there is not a generally accepted treatment for ET, PV and MMM, which can reduce the risk of thromboembolism and/or hemorragic events. In several subsets of ET and PV patients, IFN-alpha can be considered as first line therapy. IFN-alpha is usually associated with the development of early and later side effects, that reduce the enthusiasm for its use. In the future PEG-IFN-alpha would improve the quality of life of IFN-treated CMD patients.

Clinical Trials as Topic↗
PubMedDate not supplied

Autonomic functions in type 1 (insulin-dependent) diabetes.

In juvenile type 1 diabetes a computer-aided orthoclinostatic test, giving information on central autonomic reactivity, shows a significant difference, vs control subjects, only in the ortho-to-clino transition (not in clino-to-ortho), while no differences emerge in peripheral autonomic functions. The correlations between the mean values of heart rate in lying and standing positions seem to indicate a different response of the baroceptor reflex in the two groups.

Adolescent↗